公开(公告)号：US20090098275A1

公开(公告)日：2009-04-16

申请号：US12344085

申请日：2008-12-24

申请人： Xueju Xie ,  Yu-Lung (Edward) Ko ,  Chien-Kuang (David) Ko ,  Jason Jiang-Chung Ko

发明人： Xueju Xie ,  Yu-Lung (Edward) Ko ,  Chien-Kuang (David) Ko ,  Jason Jiang-Chung Ko

IPC分类号： B05D3/02 ,  C09D101/08

CPC分类号： A61K9/4891 ,  A61K9/286 ,  A61K9/2866 ,  C08K5/0016 ,  C08L1/28 ,  C08L5/04 ,  C09D101/28 ,  C09D105/04 ,  C08L2666/26

摘要： A dry suspendible enteric coating composition for suspension in water and then encasing orally ingestible articles. The dry suspendible enteric coating composition comprises a pH-dependent polymer selected from a group containing alginates and alginic acids, a pH-independent water insoluble polymer selected from the group comprising ethylcellulose and ethylcellulose-containing compositions, and a plasticizer selected from the group containing triethyl citrate, glycerin, propylene glycol, triacetin, acetylated monoglycerides, dibutyl sebacate, polyethylene glycols, sorbitals, middle chain triglycerides and combinations thereof. A three-step method for providing a stable outer enteric coating on an ingestible item comprising a first step of encasing the item with a suspension comprising a mixture of at least a sugar and a microcrystalline cellulose, a second step of then encasing the item with a suspension comprising a mixture of a film-forming polymer and a plasticizer, and a third step of finally encasing the item with the enteric coating composition.

摘要翻译： 一种用于悬浮在水中然后包裹口服可摄取物品的干燥悬浮肠溶包衣组合物。 干悬浮肠溶包衣组合物包含选自含有藻酸盐和海藻酸的pH依赖性聚合物，选自乙基纤维素和含乙基纤维素的组合物的基于pH的不溶于水的聚合物，以及选自三乙基 柠檬酸盐，甘油，丙二醇，甘油三乙酸酯，乙酰化单酸甘油酯，癸二酸二丁酯，聚乙二醇，山梨醇，中链甘油三酯及其组合。 一种用于在可摄入物品上提供稳定的外肠衣的三步法，其包括用包含至少糖和微晶纤维素的混合物的悬浮液包裹物品的第一步骤，然后将所述物品与 包含成膜聚合物和增塑剂的混合物的悬浮液，以及最终用肠溶剂组合物包装该物品的第三步骤。