公开(公告)号：US09422598B2

公开(公告)日：2016-08-23

申请号：US13698219

申请日：2010-06-04

申请人： Xun Ye ,  Fei Wu ,  Qinghua Xu ,  Xia Meng ,  Bruno Mougin ,  Fang Liu

发明人： Xun Ye ,  Fei Wu ,  Qinghua Xu ,  Xia Meng ,  Bruno Mougin ,  Fang Liu

IPC分类号： C07H21/04 ,  C12Q1/68 ,  C40B40/06

CPC分类号： C12Q1/6886 ,  C12Q1/6837 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  C40B40/06

摘要： A method and kit for the prognosis of colorectal cancer where the method includes the steps of: a) obtaining a peripheral blood sample and extracting total RNA from the sample, b) contacting the total RNA with at least one reagent specific for at least one NK cell gene and no more than 25 specific reagents for 25 NK cell genes, c) determining the expression level of at least one and at most 25 NK cell genes to obtain an expression profile for the patient, d) analyzing the expression profile with expression profiles previously clinically classified as a good prognosis and as a poor prognosis, wherein if the expression profile is clustered with the poor prognosis profiles, then the patient is determined to have a poor prognosis, and if the expression profile is clustered with the good prognosis profiles, then the patient is determined to have a good prognosis.

摘要翻译： 一种用于结肠直肠癌预后的方法和试剂盒，其中所述方法包括以下步骤：a）获得外周血样品并从样品中提取总RNA，b）使总RNA与至少一种特异于至少一种NK的试剂接触 细胞基因和不超过25个特异性试剂用于25个NK细胞基因，c）确定至少一个和至多25个NK细胞基因的表达水平以获得患者的表达谱，d）用表达谱分析表达谱 以前临床分类为良好的预后和不良预后，其中如果表达谱具有不良预后特征，则确定患者的预后不良，并且如果表达谱具有良好的预后特征， 那么确定患者有良好的预后。

公开(公告)号：US20130072401A1

公开(公告)日：2013-03-21

申请号：US13698219

申请日：2010-06-04

申请人： Xun Ye ,  Fei Wu ,  Qinghua Xu ,  Xia Meng ,  Bruno Mougin ,  Fang Liu

发明人： Xun Ye ,  Fei Wu ,  Qinghua Xu ,  Xia Meng ,  Bruno Mougin ,  Fang Liu

IPC分类号： C12Q1/68 ,  C40B40/06

CPC分类号： C12Q1/6886 ,  C12Q1/6837 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  C40B40/06

摘要： A method and kit for the prognosis of colorectal cancer where the method includes the steps of: a) obtaining a peripheral blood sample and extracting total RNA from the sample, b) contacting the total RNA with at least one reagent specific for at least one NK cell gene and no more than 25 specific reagents for 25 NK cell genes, c) determining the expression level of at least one and at most 25 NK cell genes to obtain an expression profile for the patient, d) analyzing the expression profile with expression profiles previously clinically classified as a good prognosis and as a poor prognosis, wherein if the expression profile is clustered with the poor prognosis profiles, then the patient is determined to have a poor prognosis, and if the expression profile is clustered with the good prognosis profiles, then the patient is determined to have a good prognosis.

摘要翻译： 一种用于结肠直肠癌预后的方法和试剂盒，其中所述方法包括以下步骤：a）获得外周血样品并从样品中提取总RNA，b）使总RNA与至少一种特异于至少一种NK的试剂接触 细胞基因和不超过25个特异性试剂用于25个NK细胞基因，c）确定至少一个和至多25个NK细胞基因的表达水平以获得患者的表达谱，d）用表达谱分析表达谱 以前临床分类为良好的预后和不良预后，其中如果表达谱具有不良预后特征，则确定患者的预后不良，并且如果表达谱具有良好的预后特征， 那么确定患者有良好的预后。

公开(公告)号：US09689041B2

公开(公告)日：2017-06-27

申请号：US14007439

申请日：2012-03-23

申请人： Xun Ye ,  Fei Wu ,  Qinghua Xu ,  Fang Liu ,  Xia Meng ,  Bruno Mougin

发明人： Xun Ye ,  Fei Wu ,  Qinghua Xu ,  Fang Liu ,  Xia Meng ,  Bruno Mougin

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/158

摘要： The present invention provides a method for determining in vitro, in a peripheral blood sample, the probability for an individual to suffer from a colorectal cancer, using the comparison of the amount of expression products of nucleic acids of genes of the individual to be tested with the amount of expression products of nucleic acids of the same genes obtained from a CRC group of patients constituting the positive control and with the amount of expression products of nucleic acids of the same genes obtained from a CNC group of individuals constituting the negative control; and a kit comprising specific binding partners for said expression products.

公开(公告)号：US20140057802A1

公开(公告)日：2014-02-27

申请号：US14007439

申请日：2012-03-23

申请人： Xun Ye ,  Fei Wu ,  Qinghua Xu ,  Fang Liu ,  Xia Meng ,  Bruno Mougin

发明人： Xun Ye ,  Fei Wu ,  Qinghua Xu ,  Fang Liu ,  Xia Meng ,  Bruno Mougin

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6886 ,  C12Q2600/158

摘要： The present invention provides a method for determining in vitro, in a peripheral blood sample, the probability for an individual to suffer from a colorectal cancer, using the comparison of the amount of expression products of nucleic acids of genes of the individual to be tested with the amount of expression products of nucleic acids of the same genes obtained from a CRC group of patients constituting the positive control and with the amount of expression products of nucleic acids of the same genes obtained from a CNC group of individuals constituting the negative control; and a kit comprising specific binding partners for said expression products.

摘要翻译： 本发明提供了一种用于在外周血样品中测定个体遭受结肠直肠癌的可能性的方法，该方法使用待测个体的基因的核酸的表达产物的量与 从构成阳性对照的CRC组获得的相同基因的核酸的表达产物的量以及从构成阴性对照的个体的CNC组获得的相同基因的核酸的表达产物的量; 以及包含所述表达产物的特异性结合伴侣的试剂盒。

公开(公告)号：US09410188B2

公开(公告)日：2016-08-09

申请号：US13696937

申请日：2010-05-28

申请人： Xun Ye ,  Fei Wu ,  Qinghua Xu ,  Xia Meng ,  Bruno Mougin

发明人： Xun Ye ,  Fei Wu ,  Qinghua Xu ,  Xia Meng ,  Bruno Mougin

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6837 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158

摘要： A method and kit are related to discriminating between breast cancer and benign breast disease by the determination of the expression level of at least one target gene including a nucleic acid sequence selected from the nucleic acid sequences set forth in SEQ ID NOs: 1, 2 or 3, 4 and 5 or 6 to obtain an expression profile for the patient, and the comparison of the expression profile of the patient with expression profiles of target genes from patients previously clinically classified as breast cancer and expression profiles of target genes from patients previously clinically classified as benign breast disease.

摘要翻译： 一种方法和试剂盒涉及通过测定至少一种靶基因的表达水平来区分乳腺癌和良性乳腺疾病，所述至少一种靶基因包括选自SEQ ID NO：1,2所示的核酸序列的核酸序列，或 3,4和5或6以获得患者的表达谱，并且将患者的表达谱与先前临床分类为乳腺癌的患者的靶基因的表达谱和先前临床患者的靶基因的表达谱进行比较 归为良性乳腺疾病。

公开(公告)号：US20130072399A1

公开(公告)日：2013-03-21

申请号：US13696937

申请日：2010-05-28

申请人： Xun Ye ,  Fei Wu ,  Qinghua Xu ,  Xia Meng ,  Bruno Mougin

发明人： Xun Ye ,  Fei Wu ,  Qinghua Xu ,  Xia Meng ,  Bruno Mougin

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6837 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158

摘要： A method and kit are related to discriminating between breast cancer and benign breast disease by the determination of the expression level of at least one target gene including a nucleic acid sequence selected from the nucleic acid sequences set forth in SEQ ID NOs: 1, 2 or 3, 4 and 5 or 6 to obtain an expression profile for the patient, and the comparison of the expression profile of the patient with expression profiles of target genes from patients previously clinically classified as breast cancer and expression profiles of target genes from patients previously clinically classified as benign breast disease.

摘要翻译： 一种方法和试剂盒涉及通过测定至少一种靶基因的表达水平来区分乳腺癌和良性乳腺疾病，所述至少一种靶基因包括选自SEQ ID NO：1,2所示的核酸序列的核酸序列，或 3,4和5或6以获得患者的表达谱，并且将患者的表达谱与先前临床分类为乳腺癌的患者的靶基因的表达谱和先前临床患者的靶基因的表达谱进行比较 归为良性乳腺疾病。

公开(公告)号：USD679958S1

公开(公告)日：2013-04-16

申请号：US29415426

申请日：2012-03-09

申请人： Frank Yang ,  Tzu-Hao Wei ,  Di-Fong Chang ,  Po-Ling Huang ,  Myk Lum ,  Xun Ye

设计人： Frank Yang ,  Tzu-Hao Wei ,  Di-Fong Chang ,  Po-Ling Huang ,  Myk Lum ,  Xun Ye