公开(公告)号：US20240228434A1

公开(公告)日：2024-07-11

申请号：US18282940

申请日：2022-03-20

申请人： Xyzagen, Inc.

发明人： Christopher S. CREAN ,  Edward G. BROWN

IPC分类号： C07C271/28 ,  A61K31/216 ,  A61K31/44 ,  C07D213/74

CPC分类号： C07C271/28 ,  A61K31/216 ,  A61K31/44 ,  C07D213/74

摘要： Prodrugs of pharmacologically active 1,2,4-triaminobenzene derivatives of the General Formula (I); or pharmaceutically acceptable salts thereof, where the symbols R1, R2, R3, R4, R5 and R6a, R6b, and R6c and where the symbol Z are defined. Methods for the synthesis, purification, testing and use as prodrugs of pharmacologically-active agents at Kv7 ion channels are provided.

公开(公告)号：US20240300894A1

公开(公告)日：2024-09-12

申请号：US18282934

申请日：2022-03-20

申请人： Xyzagen, Inc.

发明人： Christopher S. CREAN ,  Edward G. BROWN

IPC分类号： C07D213/28 ,  A61K31/216 ,  A61K31/44 ,  C07C271/28

CPC分类号： C07D213/28 ,  A61K31/216 ,  A61K31/44 ,  C07C271/28

摘要： Prodrugs of pharmacologically active 1,2,4-triaminobenzene derivatives of the General Formula (I); or pharmaceutically acceptable salts thereof, where the symbols R1, R2, R3, R4, R5 and R6a, R6b, and R6c and where the symbol Z are defined. Methods for the synthesis, purification, testing and use as prodrugs of pharmacologically-active agents at Kv7 ion channels are provided.

公开(公告)号：US20240208896A1

公开(公告)日：2024-06-27

申请号：US18282943

申请日：2022-03-20

申请人： Xyzagen, Inc.

发明人： Christopher S. CREAN ,  Edward G. BROWN

IPC分类号： C07C271/28 ,  A61K31/27 ,  A61K31/44 ,  C07D213/75

CPC分类号： C07C271/28 ,  A61K31/27 ,  A61K31/44 ,  C07D213/75

摘要： Prodrugs of pharmacologically active 1,2,4-triaminobenzene derivatives of the General Formula (I); or pharmaceutically acceptable salts thereof, where the symbols R1, R2, R3, R4, R5 and R6a, R6b, and R6c and where the symbol Z are defined. Methods for the synthesis, purification, testing and use as prodrugs of pharmacologically-active agents at Kv7 ion channels are provided.