公开(公告)号：US20240034762A1

公开(公告)日：2024-02-01

申请号：US18043894

申请日：2021-09-02

申请人： YALE UNIVERSITY

发明人： Joseph Schlessinger ,  Yoshihisa Suzuki ,  Irit Lax

IPC分类号： C07K14/50 ,  C12N15/63 ,  A61P5/00

CPC分类号： C07K14/50 ,  C12N15/63 ,  A61P5/00 ,  C07K2319/30

摘要： The present disclosure provides in one aspect a construct comprising the R2 region of FGF23. In other embodiments, the construct functions as a FGF23 antagonist by blocking FGF23 binding to α-Klotho and cell signaling via FGFR activation. In yet other embodiments, the construct prevents FGFR activation. In yet other embodiments, the construct of the present disclosure can be used to treat diseases or disorders related to FGF23 dysregulation and/or overexpression, such as but not limited to phosphate metabolism disorders.