公开(公告)号：US20170233702A1

公开(公告)日：2017-08-17

申请号：US15498493

申请日：2017-04-27

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Rony SEGER ,  Alexander PLOTNIKOV

IPC: C12N9/12

CPC classification number: C12N9/12 ,  A61K38/00 ,  A61K38/12 ,  A61K47/64 ,  C12N9/1205 ,  C12Y207/11 ,  C12Y207/11024

Abstract: An isolated peptide being no longer than 20 amino acids comprising a sequence at least 95% homologous to the sequence GQLNHILGILGX1PX2QED (SEQ ID NO: 4), wherein X1 and X2 are any amino acid, the peptide being capable of preventing extracellular signal-regulated kinase1/2 (ERK) translocation into the nucleus.

公开(公告)号：US20160340655A1

公开(公告)日：2016-11-24

申请号：US15022280

申请日：2014-09-15

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Rony SEGER ,  Alexander PLOTNIKOV

IPC: C12N9/12

CPC classification number: C12N9/12 ,  A61K38/00 ,  A61K38/12 ,  A61K47/64 ,  C12N9/1205 ,  C12Y207/11 ,  C12Y207/11024

Abstract: An isolated peptide being no longer than 20 amino acids comprising a sequence at least 95% homologous to the sequence GQLNHILGILGX1PX2QED (SEQ ID NO: 4), wherein X1 and X2 are any amino acid, the peptide being capable of preventing extracellular signal-regulated kinase1/2 (ERK) translocation into the nucleus.

Abstract translation: 分离的肽不超过20个氨基酸，其包含与序列GQLNHILGILGX1PX2QED（SEQ ID NO：4）至少95％同源的序列，其中X1和X2是任何氨基酸，该肽能够预防细胞外信号调节激酶1 / 2（ERK）易位进入细胞核。