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公开(公告)号：US20160340655A1
公开(公告)日：2016-11-24
申请号：US15022280
申请日：2014-09-15
Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
Inventor： Rony SEGER , Alexander PLOTNIKOV
IPC: C12N9/12
CPC classification number: C12N9/12 , A61K38/00 , A61K38/12 , A61K47/64 , C12N9/1205 , C12Y207/11 , C12Y207/11024
Abstract: An isolated peptide being no longer than 20 amino acids comprising a sequence at least 95% homologous to the sequence GQLNHILGILGX1PX2QED (SEQ ID NO: 4), wherein X1 and X2 are any amino acid, the peptide being capable of preventing extracellular signal-regulated kinase1/2 (ERK) translocation into the nucleus.
Abstract translation: 分离的肽不超过20个氨基酸，其包含与序列GQLNHILGILGX1PX2QED（SEQ ID NO：4）至少95％同源的序列，其中X1和X2是任何氨基酸，该肽能够预防细胞外信号调节激酶1 / 2（ERK）易位进入细胞核。
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公开(公告)号：US20180066286A1
公开(公告)日：2018-03-08
申请号：US15800132
申请日：2017-11-01
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Rony SEGER , Dana CHUDERLAND
Abstract: Isolated peptides comprising nuclear targeting activity or being capable of preventing endogenous nuclear targeting activity are disclosed. Polynucleotides encoding same, pharmaceutical compositions comprising same, as well as uses thereof are also disclosed.
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公开(公告)号：US20160052967A1
公开(公告)日：2016-02-25
申请号：US14778624
申请日：2014-04-24
Applicant: YEDA RESEARCH AND DEVELOPMENT CO., LTD.
Inventor： Rony SEGER , Eldar ZEHORAI
CPC classification number: C07K7/06 , A61K38/00 , A61K38/08 , A61K47/48046 , C07K7/08
Abstract: An isolated peptide is disclosed which comprises an amino acid sequence being at least 80% homologous to the sequence as set forth in SEQ ID NO: 1 (PERYQNLSPV), the isolated peptide comprising a nuclear targeting activity, the peptide being no longer than 20 amino acids.
Abstract translation: 公开了分离的肽，其包含与SEQ ID NO：1（PERYQNLSPV）所示的序列至少80％同源的氨基酸序列，所述分离的肽包含核靶向活性，所述肽不超过20个氨基 酸。
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公开(公告)号：US20210292338A1
公开(公告)日：2021-09-23
申请号：US17337570
申请日：2021-06-03
Applicant: Yeda Research and Development Co. Ltd. , Universitat de Barcelona , Institució Catalana de Recerca I Estudis Avançats
Inventor： Rony SEGER , Karen FLORES , Xavier BARRIL ALONSO , Carlos GALDEANO CANTADOR
IPC: C07D498/04 , A61K45/06 , A61P35/00
Abstract: Described herein are compounds having Formula I or Formula II: wherein each dashed line independently represents a saturated or unsaturated bond; R1 and R′1 are aryl or heteroaryl as defined herein; and R2 and R′2 are as defined herein. Further described is a method of inhibiting nuclear translocation of ERK1/2 in a cell, by contacting the cell with a compound having Formula I or Formula II. The compounds may also be for use in treating a disease or disorder associated with nuclear translocation of ERK1/2.
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Patent Agency Ranking
公开(公告)号：US20210154261A1
公开(公告)日：2021-05-27
申请号：US16633175
申请日：2018-07-24
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Yardena SAMUELS , Rand ARAFEH , Karen FLORES , Rony SEGER , Ehud WAINSTEIN
IPC: A61K38/10 , A61K31/519 , A61K31/4184 , A61P35/00
Abstract: An article of manufacture is disclosed which comprises: (i) a peptide agent which is capable of preventing extracellular signal-regulated kinase1/2 (ERK) translocation into the nucleus; and (ii) a MEK inhibitor. Uses thereof are also disclosed.
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公开(公告)号：US20170233702A1
公开(公告)日：2017-08-17
申请号：US15498493
申请日：2017-04-27
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Rony SEGER , Alexander PLOTNIKOV
IPC: C12N9/12
CPC classification number: C12N9/12 , A61K38/00 , A61K38/12 , A61K47/64 , C12N9/1205 , C12Y207/11 , C12Y207/11024
Abstract: An isolated peptide being no longer than 20 amino acids comprising a sequence at least 95% homologous to the sequence GQLNHILGILGX1PX2QED (SEQ ID NO: 4), wherein X1 and X2 are any amino acid, the peptide being capable of preventing extracellular signal-regulated kinase1/2 (ERK) translocation into the nucleus.
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公开(公告)号：US20170283457A1
公开(公告)日：2017-10-05
申请号：US15623433
申请日：2017-06-15
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Rony SEGER , Eldar ZEHORAI
CPC classification number: C07K7/06 , A61K38/00 , A61K38/08 , A61K47/543 , C07K7/08
Abstract: An isolated peptide is disclosed which comprises an amino acid sequence being at least 80% homologous to the sequence as set forth in SEQ ID NO: 1 (PERYQNLSPV), the isolated peptide comprising a nuclear targeting activity, the peptide being no longer than 20 amino acids.
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公开(公告)号：US20160222415A1
公开(公告)日：2016-08-04
申请号：US15097340
申请日：2016-04-13
Applicant: Yeda Research and Development Co. Ltd.
Inventor： Rony SEGER , Dana CHUDERLAND
CPC classification number: C12N15/87 , A61K48/0041 , C07K7/08 , C07K14/47 , C07K16/18 , C07K16/2866 , C07K2319/09 , C12N15/113 , C12N2810/85
Abstract: Isolated peptides comprising nuclear targeting activity or being capable of preventing endogenous nuclear targeting activity are disclosed. Polynucleotides encoding same, pharmaceutical compositions comprising same, as well as uses thereof are also disclosed.
Abstract translation: 公开了包含核靶向活性或能够预防内源性核靶向活性的分离的肽。 编码相同的多核苷酸，包含其的药物组合物及其用途也被公开。
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公开(公告)号：US20140212438A1
公开(公告)日：2014-07-31
申请号：US14243923
申请日：2014-04-03
Applicant: Yeda Research and Development Co., Ltd.
Inventor： Rony SEGER , Dana Chuderland
IPC: C07K7/08 , C07K16/18 , C12N15/113
CPC classification number: C12N15/87 , A61K48/0041 , C07K7/08 , C07K14/47 , C07K16/18 , C07K16/2866 , C07K2319/09 , C12N15/113 , C12N2810/85
Abstract: Isolated peptides comprising nuclear targeting activity or being capable of preventing endogenous nuclear targeting activity are disclosed. Polynucleotides encoding same, pharmaceutical compositions comprising same, as well as uses thereof are also disclosed.
Abstract translation: 公开了包含核靶向活性或能够预防内源性核靶向活性的分离的肽。 编码相同的多核苷酸，包含其的药物组合物及其用途也被公开。
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