公开(公告)号：US20210348179A1

公开(公告)日：2021-11-11

申请号：US17381245

申请日：2021-07-21

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Asaph AHARONI ,  Samuel BOCOBZA ,  Tal DAHAN ,  Avraham A. LEVY

IPC: C12N15/82 ,  C12N15/86 ,  C07K14/08

Abstract: Disclosed herein are methods for gene targeting in a plant cell, as well as recombinant nucleic acid molecules used in these methods. Further disclosed are recombinant nucleic acid molecules comprising a target gene operably linked to a regulatory region of the UBQ10 gene.

公开(公告)号：US20210032645A1

公开(公告)日：2021-02-04

申请号：US16476561

申请日：2018-01-11

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Avraham A. LEVY ,  Cathy MELAMED-BESSUDO ,  Shdema FILLER-HAYUT

IPC: C12N15/82

Abstract: Methods of targeted recombination between homologous chromosomes in the genome of a somatic plant cell are described herein, wherein the target site may be located within a region of euchromatin or a region of heterochromatin. These methods may be used to induce a somatic plant cell into using targeted recombination between homologous chromosomes leading to targeted crossover or gene conversion. Methods described utilize a preselected endogenous target site at a locus having polymorphic alleles on the homologous chromosomes. Target site loci disclosed include those within euchromatin and heterochromatin.