公开(公告)号：US10557852B2

公开(公告)日：2020-02-11

申请号：US15307011

申请日：2015-04-28

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： David Margulies ,  Leila Motiei ,  Naama Mankovski ,  Yael Nissinkorn

IPC: G01N33/58 ,  G01N33/68

Abstract: This invention is directed to monomolecular sensors, comprising a selective binder, a non-selective binder and a fluorophore, which can track changes that occur on the surface of labeled proteins. This invention is further directed to the use of such sensors for identifying binding partners of specific proteins. This invention is further directed to His-tag binding compounds and uses thereof in the preparation of genetically targeted detectable molecules and sensors which can specifically bind tag-labeled proteins.