公开(公告)号：US20150362490A1

公开(公告)日：2015-12-17

申请号：US14754785

申请日：2015-06-30

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： David MARGULIES ,  Leila Motiei ,  Zohar Pode

IPC: G01N33/573 ,  C07K7/06

CPC classification number: G01N33/53 ,  C07D417/06 ,  C07D417/14 ,  C07F9/6541 ,  C07K7/06 ,  C09K11/06 ,  C09K2211/1029 ,  C09K2211/1037 ,  G01N33/573 ,  G01N33/574 ,  G01N33/582 ,  G01N2333/91177 ,  G01N2333/918 ,  G01N2333/96494

Abstract: The present invention is directed to fluorescent protein biosensors based on oligonucleotide cross reactive sensor arrays including a selective and a non-selective protein surface binding domain for protein detection. Interaction of different protein isoforms with the sensors of this invention yields a unique optical signature for each protein. The unique optical signature allows differentiating between closely related protein isoforms and diagnosing diseases and disorders associated with the proteins also in biofluids.

Abstract translation: 本发明涉及基于寡核苷酸交叉反应性传感器阵列的荧光蛋白生物传感器，其包括用于蛋白质检测的选择性和非选择性蛋白质表面结合结构域。 不同蛋白质同种型与本发明传感器的相互作用产生了每种蛋白质独特的光学特征。 独特的光学特征允许区分密切相关的蛋白质同种型，并在生物流体中诊断与蛋白质相关的疾病和病症。

公开(公告)号：US10281459B2

公开(公告)日：2019-05-07

申请号：US14754785

申请日：2015-06-30

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： David Margulies ,  Leila Motiei ,  Zohar Pode

IPC: C07K7/06 ,  G01N33/58 ,  G01N33/53 ,  C07D417/06 ,  C07D417/14 ,  C07F9/6541 ,  G01N33/574 ,  G01N33/573 ,  C09K11/06

Abstract: The present invention is directed to fluorescent protein biosensors based on oligonucleotide cross reactive sensor arrays including a selective and a non-selective protein surface binding domain for protein detection. Interaction of different protein isoforms with the sensors of this invention yields a unique optical signature for each protein. The unique optical signature allows differentiating between closely related protein isoforms and diagnosing diseases and disorders associated with the proteins also in biofluids.