公开(公告)号：US20240327383A1

公开(公告)日：2024-10-03

申请号：US18578195

申请日：2022-07-14

申请人： YICHANG HUMANWELL PHARMACEUTICAL CO., LTD. ,  TSINGHUA UNIVERSITY

发明人： Jian WANG ,  Xijun SHENG ,  Lie LI ,  Luanyuan TIAN ,  Jinliang LV ,  Miao WANG ,  Hao ZHOU ,  Xiaoqing YANG

IPC分类号： C07D401/14 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/541 ,  A61P29/00 ,  C07D401/04 ,  C07D405/14 ,  C07D409/14 ,  C07D491/10

CPC分类号： C07D401/14 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/541 ,  A61P29/00 ,  C07D401/04 ,  C07D405/14 ,  C07D409/14 ,  C07D491/10

摘要： A piperidine derivative, and a pharmaceutical composition thereof, a preparation method therefor, and a use thereof. A compound of the piperidine derivative is as shown in formula (I), and definitions of substituents are detailed in the description. The piperidine derivative can be used as a bifunctional selective ligand for a μ(mu)-opioid peptide receptor (MOPR) and a κ(kappa)-opioid peptide receptor (KOPR), or a bifunctional selective ligand for a MOPR and a nociceptin opioid peptide receptor (NOPR)/opioid receptor like-1 (ORL-1) receptor. Such a compound or a pharmaceutical composition thereof can be used for treating pain, anxiety, depression, alcohol addiction, and substance abuse/dependence.

公开(公告)号：US20160196686A1

公开(公告)日：2016-07-07

申请号：US14916982

申请日：2013-12-25

申请人： TSINGHUA UNIVERSITY

发明人： Shimin HU ,  Fanglue ZHANG ,  Miao WANG

IPC分类号： G06T17/00 ,  G06K9/46 ,  G06F17/30 ,  G06T11/60

CPC分类号： G06T17/005 ,  G06F17/30256 ,  G06F17/3028 ,  G06K9/46 ,  G06T7/162 ,  G06T11/60 ,  G06T2207/20156

摘要： The present invention relates to the technical field of image processing, and in particular, to a patch net model for image representation and a construction method of the patch net model. The patch net model for image representation is of a forest-shaped structure consisting of a plurality of composite nodes and basic nodes, each composite node is a non-leaf node, and each basic node is a leaf node; the basic node includes a certain patch region of an image and a representative patch representing an apparent feature of the patch region; the composite node includes a certain patch region of the image and can be further decomposed into basic nodes and/or composite nodes; an edge exists between two nodes, which are located on the same layer of the forest-shaped structure and are spatially connected, and a relation matrix used for expressing the spatial relative position of the two nodes is arranged on the edge.

摘要翻译： 本发明涉及图像处理的技术领域，特别涉及图像表示的补丁网模型和补丁网模型的构造方法。 图像表示的补丁网模型是由多个复合节点和基本节点组成的森林状结构，每个复合节点是非叶节点，每个基本节点是叶节点; 基本节点包括图像的特定补丁区域和表示补丁区域的明显特征的代表补丁; 复合节点包括图像的某个补丁区域，并且可以进一步分解成基本节点和/或复合节点; 在两个节点之间存在一个边缘，它们位于森林状结构的同一层上，并且在空间上连接，并且用于表示两个节点的空间相对位置的关系矩阵被布置在边缘上。