公开(公告)号：US3859275A

公开(公告)日：1975-01-07

申请号：US25828572

申请日：1972-05-31

申请人： YOSHITOMI PHARMACEUTICAL

发明人： NAKANISHI MICHIO ,  SHIROKI MASAMI ,  TAHARA TETSUYA ,  ARAKI KAZUHIKO

IPC分类号： C07D495/04 ,  C07D53/02

CPC分类号： C07D495/04

摘要： Thienodiazepine compounds of the general formula:

WHEREIN Hal is a halogen; each of R1, R2 and R3 is selected from the group consisting of H and an alkyl group having 1 to 4 carbon atoms, inclusive; R is selected from the group consisting of H, OCOCH3 and OH; and n is 1 when R is H, and n is 0 when R is selected from the group consisting of -OCOCH3 and OH; and pharmaceutically acceptable addition salts thereof which are useful as minor tranquilizers (antianxiety drugs) are disclosed.

公开(公告)号：US3887543A

公开(公告)日：1975-06-03

申请号：US43759074

申请日：1974-01-29

申请人： YOSHITOMI PHARMACEUTICAL

发明人： NAKANISHI MICHIO ,  SHIROKI MASAMI ,  TAHARA TETSUYA ,  ARAKI KAZUHIKO

IPC分类号： C07D495/04 ,  C07D99/06

CPC分类号： C07D495/04

摘要： A thieno (2,3-e)(1,4) diazepine compound of the formula:

WHEREIN Hal is a halogen atom, and Am is an -NH2 or -CONHCH3 group; and a pharmaceutically acceptable salt thereof. Hal is selected from the group consisting of F, Cl, Br and I. The compounds encompassed within the formula presented above exhibit pharmacologic activities in the form of narcosis potentiation, suppression of fighting behavior, an anticonvulsant activity, which activities permit such compounds to be employed in the treatment of anxiety neuroses, hypochrondriasis, hysteria, depression states, psychosomatic illnesses, and epilepsy.

摘要翻译： 噻吩并[2,3-e] [1,4]二氮杂化合物：

公开(公告)号：US3920679A

公开(公告)日：1975-11-18

申请号：US37235473

申请日：1973-06-21

申请人： YOSHITOMI PHARMACEUTICAL

发明人： NAKANISHI MICHIO ,  TAHARA TETSUYA ,  ARAKI KAZUHIKO ,  SHIROKI MASAMI

IPC分类号： C07D495/14 ,  C07D513/14

CPC分类号： C07D495/14 ,  C07D513/14 ,  Y10S514/96

摘要： WHEREIN X is a member selected from the group consisting of a hydrogen atom, a halogen atom, a trifluoromethyl group, an alkoxy group having 1 to 4 carbon atoms and an alkyl group having 1 to 4 carbon atoms; each of R1 and R2 is a member selected from the group consisting of a hydrogen atom and an alkyl group having 1 to 4 carbon atoms, or R1 and R2 together form a tetramethylene group, i.e. -(CH2)4-; and R is a member selected from the group consisting of -CH CH-, -N N- and -CO-O-; and pharmaceutically acceptable acid addition salts thereof are disclosed. They are useful as minor tranquilizers.

Thienodiazepine compounds of the formula:

摘要翻译： 噻吩并二氮杂化合物，其分子式如下：

公开(公告)号：US3904641A

公开(公告)日：1975-09-09

申请号：US26175772

申请日：1972-06-12

申请人： YOSHITOMI PHARMACEUTICAL

发明人： NAKANISHI MICHIO ,  TAHARA TETSUYA ,  ARAKI KAZUHIKO ,  SHIROKI MASAMI

IPC分类号： C07D495/04 ,  C07D495/14

CPC分类号： C07D495/04 ,  C07D495/14 ,  Y10S514/96

摘要： Triazolothienodiazepine compounds of the formula:

wherein Ar is a member selected from the group consisting of a phenyl group optionally substituted and a pyridyl group; each of R1 and R2 is a member selected from the group consisting of a hydrogen atom and an alkyl group having 1 to 4 carbon atoms, or R1 and R2 together form a tetramethylene group, i.e. -(CH2)4-; and R is a member selected from the group consisting of a hydrogen atom, an alkyl group having 1 to 4 carbon atoms and a phenyl group optionally substituted; and pharmaceutically acceptable acid addtion salts thereof are disclosed. They are useful as minor tranquillizers.