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    Thienodiazepine compounds
    1.
    发明授权
    Thienodiazepine compounds 失效
    三硝基脲化合物

    公开(公告)号：US3859275A

    公开(公告)日：1975-01-07

    申请号：US25828572

    申请日：1972-05-31

    申请人： YOSHITOMI PHARMACEUTICAL

    发明人： NAKANISHI MICHIO ,  SHIROKI MASAMI ,  TAHARA TETSUYA ,  ARAKI KAZUHIKO

    IPC分类号： C07D495/04 ,  C07D53/02

    CPC分类号： C07D495/04

    摘要： Thienodiazepine compounds of the general formula:

    WHEREIN Hal is a halogen; each of R1, R2 and R3 is selected from the group consisting of H and an alkyl group having 1 to 4 carbon atoms, inclusive; R is selected from the group consisting of H, OCOCH3 and OH; and n is 1 when R is H, and n is 0 when R is selected from the group consisting of -OCOCH3 and OH; and pharmaceutically acceptable addition salts thereof which are useful as minor tranquilizers (antianxiety drugs) are disclosed.

    Tetrahydropyrazolodiazepinone compounds and methods for their production
    3.
    发明授权
    Tetrahydropyrazolodiazepinone compounds and methods for their production 失效
    四氢吡咯并噻嗪酮化合物及其生产方法

    公开(公告)号：US3700657A

    公开(公告)日：1972-10-24

    申请号：US3700657D

    申请日：1971-05-18

    申请人： PARKE DAVIS & CO

    发明人： NORDIN IVAN C

    IPC分类号： C07D487/04 ,  C07D53/02

    CPC分类号： C07D487/04

    摘要： 3 - METHYL - 4,6,7,8 - TETRAHYDROPYRAZOLO(4,3-E)(1,4)DIAZEPIN-5(1H)-ONE, SUBSTITUTED IN THE 1-POSITION BY LOWER ALKYL AND OPTIONALLY IN THE 4- AND 7-POSITIONS BY METHYL; SALTS THEREOF; AND THEIR PRODUCTION BY CATALYTICALLY HYDROGENATING A DIHYDROPYAZOLODIAZEPINONE, OR BY REACTING ONE OF THE 7-UNSUBSTITUTERD TETRAHYDROPYRAZOLODIAZEPINONES WITH A METHYLATING AGENT. THE COMPOUNDS OF THE INVENTION ARE USEFUL AS ANTICONVULSANT AGENTS.

    5-substituted 54)diazepin-11-ones
    5.
    发明授权
    5-substituted 54)diazepin-11-ones 失效
    5替代54）DIAZEPIN-11-ONES

    公开(公告)号：US3634408A

    公开(公告)日：1972-01-11

    申请号：US3634408D

    申请日：1969-08-07

    申请人： BOEHRINGER SOHN INGELHEIM

    发明人： SCHMIDT GUNTHER ,  ENGELHORN ROBERT ,  LEITOLD MATYAS ,  MACHLEIDT HANS

    IPC分类号： C07D243/10 ,  C07D243/38 ,  C07D53/02

    CPC分类号： C07D243/38 ,  Y10S514/906 ,  Y10S514/96 ,  Y10S514/966

    摘要： 5-SUBSTITUTED 5,10-DIHYDRO-11H-DIBENZO(B,E)(1,4) DIAZEPIN-11-ONES OF THE FORMULA

    5-((>N)-CH2-CO-),10-R1,11-(O=),R2,R3-10,11-DIHYDRO-5H-

    DIBENZO(B,E)(1,4)DIAZEPINE

    WHEREIN R1 IS HYDROGEN OR ALKYL OF 1 TO 4 CARBON ATOMS, R2 AND R3, WHICH MAY BE IDENTICAL TO OR DIFFERENT FROM EACH OTHER, ARE EACH HYDROGEN OR HALOGEN, AND

    -N
    IS A 5- TO 7-MEMBERED MONOCYCLIC HETEROCYCLIC RING WHICH MAY OPTIONALLY COMPRISES AN ADDITIONAL NITROGEN OR OXYGEN RING ATOM AND/OR MAY OPTIONALLY HAVE ONE OR TWO ALKYL OF 1 TO 4 CARBON ATOMS, A HYDROXYALKYL OF 1 TO 4 CARBON ATOMS, AN ALKOXY OF 1 TO 4 CARBON ATOMS, A BENZYL OR METHYL-BENZYL SUBSTITUENTS ATTACHED TO A RING ATOM, AND NON-TOXIC, PHARMACOLOGICALLY ACCEPTABLE ACID ADDITION SALTS THEREO, USEFUL AS INHIBITORS OF STOMACH ULCERS AND STOMACH JUICE SECRETION IN WARM-BLOODED ANIMALS.

    Polyphenyl 1,2-diazepines
    6.
    发明授权
    Polyphenyl 1,2-diazepines 失效
    聚苯乙烯1,2-二

    公开(公告)号：US3557088A

    公开(公告)日：1971-01-19

    申请号：US3557088D

    申请日：1968-09-25

    申请人： AMERICAN CYANAMID CO

    发明人： KLINGSBERG ERWIN

    IPC分类号： C07D243/02 ,  C07D53/02

    CPC分类号： C07D243/02

    摘要： 1,2-DIAZEPINES WHICH HAVE A PHENYL GROUP IN THE 3,5, AND 7 POSITIONS AND OPTIONALLY METHYL OR PHENYL IN THE 1-POSITION ARE PREPARED FROM A 2,4,6-TRIPHENYLTHIAPYRYLIUM SALT SUCH AS THE PERCHLORATE OR FLUOBORATE, BY REACTION WITH AN EXCESS OF HYDRAZINE, METHYLHYDRAZINE OR PHENYLHYDRAZINE, THE EXCESS OF HYDRAZINE SERVING AS SOLVENT. BY THIS METHOD THERE ARE PREPARED 2,5,7-TRIPHENYLAND 5-(P-DIMETHYLAMINOPHENYL)-3,7-DIPHENYL-4H1,2-DIAZEPINES AND 1-METHYL-3,5,7-TRIPHENYL-1H1,2-DIAZEPINE. ALL THE COMPOUNDS WHEN PROTONATED ARE USEFUL IN DYEING FIBERS HAVING ANIONIC SITES. THE 1H COMPOUNDS EXHIBIT BACTERICIDAL ACTIVITY AND THE 4H COMPOUNDS EXHIBIT VASODEPRESSOR ACTIVITY.

    Substituted thienodiazepines
    8.
    发明授权
    Substituted thienodiazepines 失效
    取代噻吩并二氮杂

    公开(公告)号：US3872089A

    公开(公告)日：1975-03-18

    申请号：US25070172

    申请日：1972-05-05

    申请人： HOFFMANN LA ROCHE

    发明人： HROMATKA OTTO ,  BINDER DIETER

    IPC分类号： C07D333/36 ,  C07D53/02 ,  C07D63/18

    CPC分类号： C07D333/36 ,  Y10S514/906

    摘要： 5-Substituted-phenyl-thienodiazepines bearing a halogen or nitro substituent on the thieno ring are disclosed together with processes for their preparation and novel intermediates employed in these processes. These novel thienodiazepines are useful as muscle relaxants and sedatives.

    摘要翻译： 在噻吩环上带有卤素或硝基取代基的5-取代的苯基 - 噻吩并二氮杂与其制备方法一起公开并在这些方法中使用的新型中间体。 这些新颖的噻吩二氮卓类可用作肌肉松弛剂和镇静剂。

    Fused bi-and tricyclic,di-,tri-and thiodiaza compounds
    9.
    发明授权
    Fused bi-and tricyclic,di-,tri-and thiodiaza compounds 失效
    熔融的双 - 和三聚，二 - ，三 - 和三硝基化合物

    公开(公告)号：US3830802A

    公开(公告)日：1974-08-20

    申请号：US25773972

    申请日：1972-05-30

    申请人： SANDOZ AG

    发明人： EBERLE M ,  HOULIHAN W

    IPC分类号： C07D513/04 ,  C07D53/00 ,  C07D53/02 ,  C07D93/40

    CPC分类号： C07D513/04

    摘要： FUSED BI- AND TRICYCLIC, DI-, TRI- AND THIODIAZA COMPOUNDS, E,G, 2,3,3A,10 -TETRAHYDRO-3-PHENYLBENZO (B) PYRROLO(2,3-E)(1,4)DIAZEPIN-4(3H)-ONE PREPARED BY TREATING A CORRESPONDNG SUBSTITUTED PYRIDINE OR PYRROLINE WITH A SUBSTITUTED ANILINE O-PHENYLENEDIAMINE, ETHYLENEDIAMINE OR DIAMINOPROPANE. THE COMPOUNDS ARE USEFUL AS TRANQUILIZERS AND HYPOTENSIVES.