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公开(公告)号:US10941136B2
公开(公告)日:2021-03-09
申请号:US16096712
申请日:2017-04-26
申请人: YUHAN CORPORATION
发明人: Young-Hwan Kim , Tae-Dong Han , Dong-Hoon Kim , Eun-Hye Jung , Su-Bin Choi , Eui-Chul Lee , Won-Ee Chong , Jin-Hwi Park , Jun-Chul Park , Ho-Woong Kang , Ji-Yeong Gal , Chan-Sun Park , Jong-Gyun Kim , Su-Youn Nam
IPC分类号: C07D239/91 , C07D403/14 , C07D217/24 , A61K31/51 , A61K31/506 , C07D403/12
摘要: The present invention provides a quinazoline derivative or its pharmaceutically acceptable salt, a process for the preparation thereof, a pharmaceutical composition comprising the same and a use thereof. The quinazoline derivative or its pharmaceutically acceptable salt has a selective inhibitory activity against the phosphatidylinositol 3-kinase delta subunit, and therefore can be usefully applied for preventing or treating cancer, along with avoiding side effects such as lymphopenia-associated inflammatory responses.