公开(公告)号：US20230085912A1

公开(公告)日：2023-03-23

申请号：US17822443

申请日：2022-08-26

申请人： YUHAN CORPORATION ,  JANSSEN BIOTECH, INC.

发明人： Byoungmoon LEE ,  Hyunjoo LEE ,  Gyu Jin LEE ,  Su Bin CHOI ,  Misong KIM ,  Young Ae YOON ,  Kwan Hoon HYUN ,  Jae Young SIM ,  Marian C. BRYAN ,  Scott KUDUK ,  James Campbell ROBERTSON ,  Jaekyoo LEE ,  Paresh Devidas SALGAONKAR ,  Byung-Chul SUH ,  Jong Sung KOH ,  So Young HWANG

IPC分类号： C07D401/14

摘要： Provided are 5-membered heteroaryl-containing aminopyridine compounds and pharmaceutically acceptable compositions thereof which exhibit inhibition activity against certain mutated forms of EGFR.

公开(公告)号：US20230090406A1

公开(公告)日：2023-03-23

申请号：US17822445

申请日：2022-08-26

申请人： YUHAN CORPORATION ,  JANSSEN BIOTECH, INC.

发明人： Hyunjoo LEE ,  Su Bin CHOI ,  Misong KIM ,  Young Ae YOON ,  Kwan Hoon HYUN ,  Jae Young SIM

IPC分类号： C07D401/14 ,  C07D413/14

摘要： Provided are 6-membered heteroaryl-containing aminopyridine compounds and pharmaceutically acceptable compositions thereof which exhibit inhibition activity against certain mutated forms of EGFR.

公开(公告)号：US20230086884A1

公开(公告)日：2023-03-23

申请号：US17822450

申请日：2022-08-26

申请人： YUHAN CORPORATION ,  JANSSEN BIOTECH, INC.

发明人： Byoungmoon LEE ,  Hyunjoo LEE ,  Gyu Jin LEE ,  Su Bin CHOI ,  Sol PARK ,  Heejun KIM ,  Misong KIM ,  Young Ae YOON ,  Kwan Hoon HYUN ,  Tae Kyun KIM ,  Jae Young SIM ,  Marian C. BRYAN ,  Scott KUDUK ,  James Campbell ROBERTSON

IPC分类号： C07D401/14

摘要： Provided are aminopyridine compounds and pharmaceutically acceptable compositions thereof which exhibit inhibition activity against certain mutated forms of EGFR.

公开(公告)号：US20230086795A1

公开(公告)日：2023-03-23

申请号：US17822438

申请日：2022-08-26

申请人： YUHAN CORPORATION ,  JANSSEN BIOTECH, INC.

发明人： Hyunjoo LEE ,  Su Bin CHOI ,  Young Ae YOON ,  Kwan Hoon HYUN ,  Jae Young SIM ,  Marian C. BRYAN ,  Scott KUDUK ,  James Campbell Robertson ,  Jaekyoo LEE ,  Paresh Devidas SALGAONKAR ,  Byung-Chul SUH ,  Jong Sung KOH ,  So Young HWANG

IPC分类号： C07D401/14

摘要： Provided are aminopyridine compounds and pharmaceutically acceptable compositions thereof which exhibit inhibition activity against certain mutated forms of EGFR.

公开(公告)号：US20170152241A9

公开(公告)日：2017-06-01

申请号：US14893517

申请日：2014-05-23

申请人： YUHAN CORPORATION

发明人： Jae Young SIM ,  Myung Hun CHA ,  Tae Kyun KIM ,  Young Ae YOON ,  Dong Hoon KIM

IPC分类号： C07D403/04 ,  C07D409/14 ,  C07D401/04

CPC分类号： C07D403/04 ,  C07D401/04 ,  C07D409/14

摘要： The present invention provides: a bicyclic derivative comprising a pyrimidine ring, or a pharmaceutically acceptable salt thereof; a preparation method therefor, a pharmaceutical composition comprising the same; and a use therefor. According to the present invention, the bicyclic compound derivative comprising a pyrimidine ring, or a pharmaceutically acceptable salt thereof acts as a 5-HT4 receptor agonist, and thus can be usefully applied to the prevention or treatment of dysfunction in gastrointestinal motility, for example, gastrointestinal diseases such as gastroesophageal reflux disease (GERD), constipation, irritable bowel syndrome (IBS), dyspepsia, post-operative ileus, delayed gastric emptying, gastroparesis, intestinal pseudo-obstruction, drug-induced delayed transit, diabetic gastric atony and the like.

公开(公告)号：US20160090374A1

公开(公告)日：2016-03-31

申请号：US14893517

申请日：2014-05-23

申请人： YUHAN CORPORATION

发明人： Jae Young SIM ,  Myung CHA ,  Tae Kyun KIM ,  Young Ae YOON ,  Dong Hoon KIM

IPC分类号： C07D403/04 ,  C07D409/14 ,  C07D401/04

CPC分类号： C07D403/04 ,  C07D401/04 ,  C07D409/14

摘要： The present invention provides: a bicyclic derivative comprising a pyrimidine ring, or a pharmaceutically acceptable salt thereof; a preparation method therefor, a pharmaceutical composition comprising the same; and a use therefor. According to the present invention, the bicyclic compound derivative comprising a pyrimidine ring, or a pharmaceutically acceptable salt thereof acts as a 5-HT4 receptor agonist, and thus can be usefully applied to the prevention or treatment of dysfunction in gastrointestinal motility, for example, gastrointestinal diseases such as gastroesophageal reflux disease (GERD), constipation, irritable bowel syndrome (IBS), dyspepsia, post-operative ileus, delayed gastric emptying, gastroparesis, intestinal pseudo-obstruction, drug-induced delayed transit, diabetic gastric atony and the like.

摘要翻译： 本发明提供：包含嘧啶环的双环衍生物或其药学上可接受的盐; 其制备方法，包含其的药物组合物; 并为此使用。 根据本发明，包含嘧啶环的双环化合物衍生物或其药学上可接受的盐用作5-HT 4受体激动剂，因此可用于预防或治疗胃肠蠕动功能障碍，例如， 消化道疾病如胃食管反流病（GERD），便秘，肠易激综合征（IBS），消化不良，手术后肠梗阻，胃排空，胃轻瘫，肠道假性梗阻，药物诱导的延迟转运，糖尿病性胃痛等 。