公开(公告)号：US11168096B2

公开(公告)日：2021-11-09

申请号：US17134404

申请日：2020-12-26

申请人： YUNNAN UNIVERSITY

发明人： Feng Gao ,  Xudan Bi ,  Yuechen Zhou ,  Rong Yang ,  Guokui Li ,  Yan Li

IPC分类号： C07F3/06 ,  A61P31/18

摘要： This disclosure relates to pharmaceutical chemistry, and more particularly to a metalloporphyrin compound, and a preparation and application thereof. The metalloporphyrin compound is shown in formula (I), or an optical isomer, a pharmaceutically-acceptable salt or a solvate thereof, and can specifically recognize the HIV RNA and effectively inhibit HIV reverse transcriptase. This disclosure also provides uses of the compound in the preparation of a reagent for selectively recognizing HIV TAR RNA and a HIV reverse transcriptase inhibitor.