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28 条记录 (耗时 0.01 秒)

    Metalloporphyrin compounds, preparation and uses thereof
    1.
    发明授权
    Metalloporphyrin compounds, preparation and uses thereof 有权

    公开(公告)号：US11168096B2

    公开(公告)日：2021-11-09

    申请号：US17134404

    申请日：2020-12-26

    申请人： YUNNAN UNIVERSITY

    发明人： Feng Gao ,  Xudan Bi ,  Yuechen Zhou ,  Rong Yang ,  Guokui Li ,  Yan Li

    IPC分类号： C07F3/06 ,  A61P31/18

    摘要： This disclosure relates to pharmaceutical chemistry, and more particularly to a metalloporphyrin compound, and a preparation and application thereof. The metalloporphyrin compound is shown in formula (I), or an optical isomer, a pharmaceutically-acceptable salt or a solvate thereof, and can specifically recognize the HIV RNA and effectively inhibit HIV reverse transcriptase. This disclosure also provides uses of the compound in the preparation of a reagent for selectively recognizing HIV TAR RNA and a HIV reverse transcriptase inhibitor.

    Skid mounted device for upper-spreading internal diffusion vertical plug flow photocatalytic wastewater treatment
    2.
    发明授权
    Skid mounted device for upper-spreading internal diffusion vertical plug flow photocatalytic wastewater treatment 有权

    公开(公告)号：US11155475B2

    公开(公告)日：2021-10-26

    申请号：US16607111

    申请日：2018-05-05

    申请人： YUNNAN UNIVERSITY

    发明人： Jiaqiang Wang ,  Wei Wang ,  Yizhou Li ,  Liang Jiang

    IPC分类号： C02F1/32 ,  C02F1/52 ,  C02F1/72 ,  C02F9/00 ,  C02F1/00 ,  C02F101/30

    摘要： A skid mounted device for upper-spreading internal diffusion vertical plug flow photocatalytic wastewater treatment includes internal diffusion vertical plug flow photocatalytic reaction tank groups and a skid base. The internal diffusion vertical plug flow photocatalytic reaction tank groups are arranged on the skid base. The internal diffusion vertical plug flow photocatalytic reaction tank groups are connected to each other in series, in parallel, or in series-parallel. Each internal diffusion vertical plug flow photocatalytic reaction tank group consists of two or more photocatalytic reaction tanks connected in series, in parallel, or in series-parallel. The wastewater pipes connected to the photocatalytic reaction tanks in each internal diffusion vertical plug flow photocatalytic reaction tank group are mounted above the photocatalytic reaction tanks.

    Method for synthesizing 4-(hydroxymethyl)benzoic acid by using P-xylene (PX) as raw material
    3.
    发明授权
    Method for synthesizing 4-(hydroxymethyl)benzoic acid by using P-xylene (PX) as raw material 审中-公开

    公开(公告)号：US10669223B2

    公开(公告)日：2020-06-02

    申请号：US16609203

    申请日：2018-05-05

    申请人： YUNNAN UNIVERSITY

    发明人： Jiaqiang Wang ,  Ying Li ,  Daomei Chen

    IPC分类号： C07C51/285 ,  B01J31/16 ,  C07C65/01

    摘要： A method for synthesizing 4-(Hydroxymethyl)benzoic acid using P-xylene (PX) as a raw material, including: dissolving PX in an organic solvent to undergo an oxidation reaction with an oxidizing agent under an action of an M-MOF catalyst; and after the oxidation reaction, performing a post-treatment to obtain the 4-(Hydroxymethyl)benzoic acid; wherein, the metal element M in the M-MOF catalyst is Fe, Cu, Cr, Mn, Cu/Fe, Cu/Cr, Cu/Mn, Fe/Mn, Cr/Fe or Cr/Mn. The by-product produced in the reaction process is little, the yield is high, and the separation is convenient. The acid-base neutralization is not required in the reaction process, reducing pollution. A one-step reaction is employed which has mild reaction conditions, short reaction time, low pollution and is convenient for industrialized mass production; and the obtained 4-(Hydroxymethyl)benzoic acid can be used for preparing medicines and liquid crystal materials having wide applications.

    Use of metal-organic framework as tumor angiogenesis inhibitor
    4.
    发明授权
    Use of metal-organic framework as tumor angiogenesis inhibitor 有权

    公开(公告)号：US10653702B2

    公开(公告)日：2020-05-19

    申请号：US15589162

    申请日：2017-05-08

    申请人： Yunnan University

    发明人： Bin Li ,  Daomei Chen ,  Jiaqiang Wang ,  Minfang Nie

    IPC分类号： A61K31/295 ,  A61K31/19 ,  A61K31/555

    摘要： The invention relates to the field of metal-organic framework materials and the field of medical technology, relates to a method for inhibiting tumor angiogenesis or preventing and/or treating tumor, comprising administering to a subject in need thereof an effective amount of a metal-organic framework comprising Fe and ligand. The invention further relates to a method for inhibiting the expression of matrix metalloproteinase in a cell, comprising administering to the cell an effective amount of a metal-organic framework comprising Fe and ligand.

    ULTRASONIC DOPPLER BLOOD FLOW IMAGING METHOD AND SYSTEM
    5.
    发明申请
    ULTRASONIC DOPPLER BLOOD FLOW IMAGING METHOD AND SYSTEM 有权

    公开(公告)号：US20220257218A1

    公开(公告)日：2022-08-18

    申请号：US17618014

    申请日：2020-09-28

    申请人： YUNNAN UNIVERSITY

    发明人： Yufeng ZHANG ,  Bingbing HE ,  Zhiyao LI ,  Hao LI ,  Xun LANG ,  Junhua ZHANG

    IPC分类号： A61B8/08 ,  A61B8/06

    摘要： An ultrasonic Doppler blood flow imaging method and system are provided. The method includes: acquiring a blood flow velocity measuring interest region and a number of transmitting sub-apertures; determining, according to the number of transmitting sub-apertures, inclination angle of a plane wave in each of the transmitting sub-aperture; determining, according to inclination angle, array element excitation delay time in each of the transmitting sub-aperture; controlling, according to array element excitation delay time, all of transmitting sub-apertures to synchronously transmit plane waves, and receiving echo signals with a full aperture; generating a radio frequency signal sequence according to echo signals; extracting blood flow Doppler signals of blood flow velocity measuring interest region according to radio frequency signal sequence; determining a blood flow velocity according to blood flow Doppler signals; and generating a Doppler blood flow image of blood flow velocity measuring interest region according to blood flow velocity.

    A reservoir tail reverse regulation method for native fish protection
    6.
    发明申请
    A reservoir tail reverse regulation method for native fish protection 审中-公开

    公开(公告)号：US20200315144A1

    公开(公告)日：2020-10-08

    申请号：US16300584

    申请日：2018-04-25

    申请人： Yunnan University

    发明人： Daming He ,  Ying Lu ,  Hailong Wang ,  Feng Pan ,  Hui Fan ,  Yulong Liu

    IPC分类号： A01K61/10 ,  E02B8/00

    摘要： The invention discloses a reservoir tail reverse regulation method for native fish protection, comprising the steps that firstly, a breeding habitat of native fishes at reservoir tail of a cascade hydroelectric dam is determined; secondly, breeding characteristics of migration native fishes are determined, and an ecological conservation project of a reach of the breeding habitat at reservoir tail is carried out; thirdly, the length of the reservoir tail of a downstream hydropower station of a cascade hydroelectric project in March to May is determined through a field investigation, and the maximum range of a natural river channel downstream of the upstream cascade power station is judged and finally, the flow state of the reach at reservoir tail is reversely regulated to achieve the goal of discharging water of the natural river channel at the reservoir tail and ensuring the natural flow state of the natural river channel.

    METHOD FOR SYNTHESIZING 4-(HYDROXYMETHYL)BENZOIC ACID BY USING P-XYLENE (PX) AS RAW MATERIAL
    7.
    发明申请
    METHOD FOR SYNTHESIZING 4-(HYDROXYMETHYL)BENZOIC ACID BY USING P-XYLENE (PX) AS RAW MATERIAL 审中-公开

    公开(公告)号：US20200062685A1

    公开(公告)日：2020-02-27

    申请号：US16609203

    申请日：2018-05-05

    申请人： YUNNAN UNIVERSITY

    发明人： Jiaqiang WANG ,  Ying LI ,  Daomei CHEN

    IPC分类号： C07C51/285 ,  B01J31/16

    摘要： A method for synthesizing 4-(Hydroxymethyl)benzoic acid using P-xylene (PX) as a raw material, including: dissolving PX in an organic solvent to undergo an oxidation reaction with an oxidizing agent under an action of an M-MOF catalyst; and after the oxidation reaction, performing a post-treatment to obtain the 4-(Hydroxymethyl)benzoic acid; wherein, the metal element M in the M-MOF catalyst is Fe, Cu, Cr, Mn, Cu Te, Cu/Cr, Cu/Mn, Fe/Mn, Cr/Fe or Cr/Mn. The by-product produced in the reaction process is little, the yield is high, and the separation is convenient. The acid-base neutralization is not required in the reaction process, reducing pollution. A one-step reaction is employed which has mild reaction conditions, short reaction time, low pollution and is convenient for industrialized mass production; and the obtained 4-(Hydroxymethyl)benzoic acid can be used for preparing medicines and liquid crystal materials having wide applications.