公开(公告)号：US07294629B2

公开(公告)日：2007-11-13

申请号：US10468788

申请日：2002-02-21

申请人： Yasunori Kitano ,  Eiji Kawahara ,  Tsuyoshi Suzuki ,  Daisuke Abe ,  Masahiro Nakajou ,  Naoko Ueda

发明人： Yasunori Kitano ,  Eiji Kawahara ,  Tsuyoshi Suzuki ,  Daisuke Abe ,  Masahiro Nakajou ,  Naoko Ueda

IPC分类号： A61K31/517 ,  C07D239/94 ,  A61K31/54 ,  A61K31/5377

CPC分类号： C07D401/06 ,  C07D239/94 ,  C07D405/06

摘要： A compound of the formula (I) or a pharmaceutically acceptable salt thereof, a hydrate thereof, a solvate thereof, an optically active compound thereof, a racemate thereof or a diastereomer mixture thereof has a superior tyrosine-specific protein kinase inhibitory activity and is useful as a pharmaceutical agent, particularly as an agent for the prophylaxis or treatment of various cancers, psoriasis or diseases caused by arteriosclerosis, and the like.

公开(公告)号：US20070265260A1

公开(公告)日：2007-11-15

申请号：US11819679

申请日：2007-06-28

申请人： Yasunori Kitano ,  Eiji Kawahara ,  Tsuyoshi Suzuki ,  Daisuke Abe ,  Masahiro Nakajou ,  Naoko Ueda

发明人： Yasunori Kitano ,  Eiji Kawahara ,  Tsuyoshi Suzuki ,  Daisuke Abe ,  Masahiro Nakajou ,  Naoko Ueda

IPC分类号： A61K31/517 ,  A61K31/496 ,  A61K31/5377 ,  A61P17/06 ,  A61P35/00 ,  A61P9/10 ,  C07D239/94 ,  C07D413/06

CPC分类号： C07D401/06 ,  C07D239/94 ,  C07D405/06

摘要： A compound of the formula (I) or a pharmaceutically acceptable salt thereof, a hydrate thereof, a solvate thereof, an optically active compound thereof, a racemate thereof or a diastereomer mixture thereof has a superior tyrosine-specific protein kinase inhibitory activity and is useful as a pharmaceutical agent, particularly as an agent for the prophylaxis or treatment of various cancers, psoriasis or diseases caused by arteriosclerosis, and the like.

摘要翻译： 式（I）化合物或其药学上可接受的盐，其水合物，其溶剂合物，其光学活性化合物，其外消旋物或非对映异构体混合物具有优异的酪氨酸特异性蛋白激酶抑制活性，并且是有用的 作为药剂，特别是作为预防或治疗各种癌症，牛皮癣或由动脉硬化引起的疾病的药剂等。