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公开(公告)号：US20060276421A1
公开(公告)日：2006-12-07
申请号：US10568226
申请日：2004-09-29
CPC分类号： A61K31/713 , C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2310/53 , C12N2320/51
摘要： Conventional oligonucleotides are opened at both ends and thereby unstable. The stability of them against catabolic enzymes is increased by phosphorothioate modification, but such phosphorothioate causes toxicity. The present invention provides oligonucleotides and medicaments in which these problems are improved. That is, it provides a staple oligonucleotides and medicaments containing the same as the active ingredient. Specifically, it provides transcription factor inhibitors, antisense oligonucleotides and siRNAs. More specifically, it provides agents for preventing, treating or improving inflammation, autoimmune diseases, central diseases, reperfusion injury in ischaemic diseases, worsened prognosis after organ transplantation or organ surgery, or restenosis after PTCA. Further specifically, it provides agents for preventing, treating or improving arthritis, dermatitis, nephritis, hepatitis, renal failure, cystitis, prostatitis, urethritis, ulcerative colitis, Crohn disease, chronic rheumatoid arthritis, osteoarthritis, atopic dermatitis, contact dermatitis, psoriasis, cutaneous ulcer or decubitus.
摘要翻译： 常规寡核苷酸在两端开放，从而不稳定。 它们对分解代谢酶的稳定性被硫代磷酸酯修饰增加，但是这种硫代磷酸酯引起毒性。 本发明提供了改善这些问题的寡核苷酸和药物。 也就是说，它提供了含有与活性成分相同的主要寡核苷酸和药物。 具体来说，它提供转录因子抑制剂，反义寡核苷酸和siRNA。 更具体地说，它提供用于预防，治疗或改善炎症，自身免疫性疾病，中枢性疾病，缺血性疾病中的再灌注损伤，器官移植或器官手术后的预后恶化或PTCA后的再狭窄的药剂。 更具体地说，它提供预防，治疗或改善关节炎，皮炎，肾炎，肝炎，肾衰竭，膀胱炎，前列腺炎，尿道炎，溃疡性结肠炎，克罗恩病，慢性类风湿性关节炎，骨关节炎，特应性皮炎，接触性皮炎，牛皮癣，皮肤 溃疡或褥疮。
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公开(公告)号：US07595301B2
公开(公告)日：2009-09-29
申请号：US10568226
申请日：2004-09-29
CPC分类号： A61K31/713 , C12N15/111 , C12N2310/11 , C12N2310/14 , C12N2310/53 , C12N2320/51
摘要： Conventional oligonucleotides are opened at both ends and thereby unstable. Their stability against catabolic enzymes is increased by phosphorothioate modification, but such phosphorothioate causes toxicity. The present invention provides oligonucleotides and medicaments in which these problems are improved. That is, it provides staple oligonucleotides and medicaments containing the same as the active ingredient. Specifically, it provides transcription factor inhibitors, antisense oligonucleotides and siRNAs. More specifically, it provides agents for preventing, treating or improving inflammation, autoimmune diseases, central diseases, reperfusion injury in ischaemic diseases, worsened prognosis after organ transplantation or organ surgery, or restenosis after PTCA. Further specifically, it provides agents for preventing, treating or improving arthritis, dermatitis, nephritis, hepatitis, renal failure, cystitis, prostatitis, urethritis, ulcerative colitis, Crohn disease, chronic rheumatoid arthritis, osteoarthritis, atopic dermatitis, contact dermatitis, psoriasis, cutaneous ulcer or decubitus.
摘要翻译： 常规寡核苷酸在两端开放，从而不稳定。 它们对分解代谢酶的稳定性通过硫代磷酸酯修饰而增加，但是这种硫代磷酸酯会引起毒性。 本发明提供了改善这些问题的寡核苷酸和药物。 也就是说，它提供含有与活性成分相同的主要寡核苷酸和药物。 具体来说，它提供转录因子抑制剂，反义寡核苷酸和siRNA。 更具体地说，它提供用于预防，治疗或改善炎症，自身免疫性疾病，中枢性疾病，缺血性疾病中的再灌注损伤，器官移植或器官手术后的预后恶化或PTCA后的再狭窄的药剂。 更具体地说，它提供预防，治疗或改善关节炎，皮炎，肾炎，肝炎，肾衰竭，膀胱炎，前列腺炎，尿道炎，溃疡性结肠炎，克罗恩病，慢性类风湿性关节炎，骨关节炎，特应性皮炎，接触性皮炎，牛皮癣，皮肤 溃疡或褥疮。
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公开(公告)号：US08697094B2
公开(公告)日：2014-04-15
申请号：US10530785
申请日：2003-10-15
申请人： Muneo Nonomura , Hiroki Ito , Hideo Hashimoto , Tadashi Urai
发明人： Muneo Nonomura , Hiroki Ito , Hideo Hashimoto , Tadashi Urai
CPC分类号： A61K9/1676 , A61K9/209 , A61K9/4808 , A61K31/4439 , A61K47/02
摘要： It is intended to provide a process for producing unstable amorphous benzimidazole compounds having a proton pump inhibitor function, and stable solid preparations for medicinal use containing these compounds which are produced by blending such an amorphous benzimidazole compound with a nontoxic base such as a basic inorganic salt, forming an intermediate coating layer on the layer containing the active ingredient and further forming an enteric coating layer or a release-controlling coating layer.
摘要翻译： 旨在提供一种制备具有质子泵抑制剂功能的不稳定无定形苯并咪唑化合物的方法，以及含有这些化合物的稳定的固体制剂，其通过将无定形苯并咪唑化合物与无毒碱如碱性无机盐 在包含活性成分的层上形成中间涂层，并进一步形成肠溶衣层或释放控制涂层。
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公开(公告)号：US20110020410A1
公开(公告)日：2011-01-27
申请号：US12821717
申请日：2010-06-23
申请人： Muneo Nonomura , Hiroki Ito , Hideo Hashimoto , Tadashi Urai
发明人： Muneo Nonomura , Hiroki Ito , Hideo Hashimoto , Tadashi Urai
IPC分类号： A61K31/4439 , A61K31/4184 , A61K9/00
CPC分类号： A61K9/1676 , A61K9/209 , A61K9/4808 , A61K31/4439 , A61K47/02
摘要： It is intended to provide a process for producing unstable amorphous benzimidazole compounds having a proton pump inhibitor function, and stable solid preparations for medicinal use containing these compounds which are produced by blending such an amorphous benzimidazole compound with a nontoxic base such as a basic inorganic salt, forming an intermediate coating layer on the layer containing the active ingredient and further forming an enteric coating layer or a release-controlling coating layer.
摘要翻译： 旨在提供一种制备具有质子泵抑制剂功能的不稳定无定形苯并咪唑化合物的方法，以及含有这些化合物的稳定的固体制剂，其通过将无定形苯并咪唑化合物与无毒碱如碱性无机盐 在包含活性成分的层上形成中间涂层，并进一步形成肠溶衣层或释放控制涂层。
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公开(公告)号：US07692505B2
公开(公告)日：2010-04-06
申请号：US11500433
申请日：2006-08-08
申请人： Hideo Hashimoto
发明人： Hideo Hashimoto
IPC分类号： H03B5/32
摘要： A crystal oscillator in which phase noise is reduced includes: a resonance circuit having a crystal unit and split capacitors connected to the crystal unit; a transistor for oscillation having a base connected to the connection node of the crystal unit and the split capacitors; an output line for connecting the node for connecting together the split capacitors and the emitter of the transistor; a crystal resonator inserted in the output line; and a resistor connected in parallel to the crystal resonator.
摘要翻译： 相位噪声减小的晶体振荡器包括：具有晶体单元的谐振电路和与晶体单元连接的分离电容器; 用于振荡的晶体管，其具有连接到晶体单元的连接节点的基极和分离电容器; 用于连接用于将分离电容器和晶体管的发射极连接在一起的节点的输出线; 插入输出线的晶体谐振器; 以及与晶体谐振器并联连接的电阻器。
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公开(公告)号：US07650659B2
公开(公告)日：2010-01-26
申请号：US10591171
申请日：2006-03-09
申请人： Hideo Hashimoto
发明人： Hideo Hashimoto
IPC分类号： D06F35/00
CPC分类号： D06F37/02 , D06F33/02 , D06F35/00 , D06F37/06 , D06F2204/065
摘要： It is intended to provide a washing method for reliably cleaning water-soluble contaminations such as sweat without damaging fabrics.A frame body 18 is disposed horizontally in a casing. The frame body 18 is rotated by a drive motor 23 in the casing. The casing and the frame body 18 are filled with water, and then clothes are placed in the frame body 18. A plurality of protrusions 40 are formed in order that an inner periphery 39 of the frame body 18 has a wavy pattern. A height of the protruding parts is set to from 3.0 to 6.0% of the inner diameter of the frame body 18. A surfant contained in cleaning liquid permeates deep into the clothes.
摘要翻译： 旨在提供一种用于可靠地清洁诸如汗水等水溶性污染而不损坏织物的洗涤方法。 框架体18水平地设置在壳体中。 框体18由壳体内的驱动马达23旋转。 壳体和框体18填充有水，然后将衣物放置在框架体18中。形成多个突起40，以使框体18的内周39具有波状图案。 突出部的高度设定为框体18的内径的3.0〜6.0％。清洗液中所含的冲洗物深入衣服。
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公开(公告)号：US07271182B2
公开(公告)日：2007-09-18
申请号：US10343142
申请日：2001-08-03
申请人： Keiji Kamiyama , Hideo Hashimoto
发明人： Keiji Kamiyama , Hideo Hashimoto
IPC分类号： A61K31/4439 , C07D401/12
CPC分类号： C07D401/12 , A61K31/4439
摘要： A sodium salt, magnesium salt, lithium salt, potassium salt, calcium salt or barium salt of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole, and a pharmaceutical composition comprising the salt. The novel salt is useful as an excellent antiulcer agent.
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公开(公告)号：US20070030083A1
公开(公告)日：2007-02-08
申请号：US11500433
申请日：2006-08-08
申请人： Hideo Hashimoto
发明人： Hideo Hashimoto
IPC分类号： H03B5/32
摘要： A crystal oscillator in which phase noise is reduced includes: a resonance circuit having a crystal unit and split capacitors connected to the crystal unit; a transistor for oscillation having a base connected to the connection node of the crystal unit and the split capacitors; an output line for connecting the node for connecting together the split capacitors and the emitter of the transistor; a crystal resonator inserted in the output line; and a resistor connected in parallel to the crystal resonator.
摘要翻译： 相位噪声减小的晶体振荡器包括：具有晶体单元的谐振电路和与晶体单元连接的分离电容器; 用于振荡的晶体管，其具有连接到晶体单元的连接节点的基极和分离电容器; 用于连接用于将分离电容器和晶体管的发射极连接在一起的节点的输出线; 插入输出线的晶体谐振器; 以及与晶体谐振器并联连接的电阻器。
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公开(公告)号：US06433309B1
公开(公告)日：2002-08-13
申请号：US09795104
申请日：2001-03-01
申请人： Hideo Hashimoto , Takeshi Uchida
发明人： Hideo Hashimoto , Takeshi Uchida
IPC分类号： H05B100
摘要： An oven-controlled oscillator includes a thermostatic oven having a heat source, a vibrator provided in the thermostatic oven, an oscillation circuit for generating an oscillation signal in response to an action of the vibrator, and a heat source control circuit. The heat source control circuit includes a sensor for detecting an internal temperature of the thermostatic oven, an operational amplifier for controlling current to flow through the heat source in response to a resistance value of the sensor so that the internal temperature of the thermostatic oven may be maintained at a predetermined preset temperature, and a feedback resistor for the operational amplifier. The feedback resistor includes a thermistor whose resistance value drops as the temperature rises, and the thermistor is thermally coupled to the thermostatic oven. Preferably, a quartz-crystal element is used as the vibrator.
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公开(公告)号：US08222422B2
公开(公告)日：2012-07-17
申请号：US12921682
申请日：2009-03-09
申请人： Hideo Hashimoto , Tadashi Urai
发明人： Hideo Hashimoto , Tadashi Urai
IPC分类号： C07D401/00 , A61K31/44
CPC分类号： C07D401/12
摘要： Provided is a crystal of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridinyl]methyl]sulfinyl]-1H-benzimidazole showing an X-ray powder diffraction pattern having characteristic peaks at interplanar spacings (d) of 10.06±0.2, 8.70±0.2, 6.57±0.2, 5.59±0.2 and 4.00±0.2 Angstroms. The present invention provides a stable antiulcer drug superior in the absorbability.
摘要翻译： 提供了（R）-2 - [[3-甲基-4-（2,2,2-三氟乙氧基）-2-吡啶基]甲基]亚磺酰基] -1H-苯并咪唑的结晶，其显示X射线粉末衍射图 在d = 10.06±0.2,8.70±0.2,6.57±0.2,5.59±0.2和4.00±0.2埃的面间距处具有特征峰。 本发明提供了在吸收性方面优异的稳定的抗溃疡药。
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