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1.发明授权Amino alcohol derivative and immunosuppresive agent having same as an active ingredient 有权氨基醇衍生物和具有与活性成分相同的免疫抑制剂公开(公告)号：US08273748B2
公开(公告)日：2012-09-25
申请号：US12310018
申请日：2007-08-07
IPC分类号： A61K31/50 , A61K31/235
CPC分类号： C07D241/08 , A61K31/137 , A61K31/27 , A61K31/4965 , A61K45/06 , C07C217/64 , C07C323/32
摘要： An amino alcohol derivative useful as an excellent immunosuppressive agent is provided.As a result of intensive research to create a highly safe compound which has an excellent immunosuppressive activity, it was discovered that an amino alcohol derivative represented by the general formula (1), has excellent immunosuppressive activity.
摘要翻译： 提供可用作优异的免疫抑制剂的氨基醇衍生物。 通过深入研究以产生具有优异的免疫抑制活性的高度安全的化合物的结果，发现由通式（1）表示的氨基醇衍生物具有优异的免疫抑制活性。
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2.发明申请AMINO ALCOHOL DERIVATIVE AND IMMUNOSUPPRESIVE AGENT HAVING SAME AS AN ACTIVE INGREDIENT 有权具有活性成分的氨基醇衍生物和免疫抑制剂公开(公告)号：US20100010000A1
公开(公告)日：2010-01-14
申请号：US12310018
申请日：2007-08-07
IPC分类号： A61K31/4965 , C07D241/06 , C07C229/28 , A61K31/216 , C07C211/01 , A61K31/135 , C07C69/612 , A61P37/06
CPC分类号： C07D241/08 , A61K31/137 , A61K31/27 , A61K31/4965 , A61K45/06 , C07C217/64 , C07C323/32
摘要： An amino alcohol derivative useful as an excellent immunosuppressive agent is provided.As a result of intensive research to create a highly safe compound which has an excellent immunosuppressive activity, it was discovered that an amino alcohol derivative represented by the general formula (1), has excellent immunosuppressive activity.
摘要翻译： 提供可用作优异的免疫抑制剂的氨基醇衍生物。 通过深入研究以产生具有优异的免疫抑制活性的高度安全的化合物的结果，发现由通式（1）表示的氨基醇衍生物具有优异的免疫抑制活性。
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3.发明授权公开(公告)号：US07807854B2
公开(公告)日：2010-10-05
申请号：US12650899
申请日：2009-12-31
申请人： Shinji Kudou , Kazuhiko Kuriyama , Tokutarou Yasue
发明人： Shinji Kudou , Kazuhiko Kuriyama , Tokutarou Yasue
IPC分类号： C07C217/34 , C07C217/56 , C07C217/64 , C07C255/54 , C07C317/22 , C07C317/32 , C07C323/32 , A61P37/06
CPC分类号： A61K31/519 , A61K31/145 , A61K31/436 , A61K38/13 , A61K45/06 , A61K2300/00
摘要： To provide a medicament which efficiently expresses an immunosuppressive agent or an anti-inflammatory agent and reduces expression of side effect.A medicament includes diaryl sulfide or diaryl ether compound having a 2-amino-1,3-propanediol structure having an activity of reducing lymphocytes circulating peripherally, in combination with an immunosuppressive agent and/or an anti-inflammatory agent.
摘要翻译： 提供有效地表达免疫抑制剂或抗炎剂并减少副作用表达的药物。 药物包括与免疫抑制剂和/或抗炎剂组合的具有减少周围循环的淋巴细胞的活性的具有2-氨基-1,3-丙二醇结构的二芳基硫醚或二芳基醚化合物。
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4.发明授权公开(公告)号：US07781617B2
公开(公告)日：2010-08-24
申请号：US11631128
申请日：2005-07-15
申请人： Shinji Kudou , Kazuhiko Kuriyama , Tokutarou Yasue
发明人： Shinji Kudou , Kazuhiko Kuriyama , Tokutarou Yasue
IPC分类号： C07C217/34 , C07C217/56 , C07C217/64 , C07C255/54 , C07C317/22 , C07C317/32 , C07C323/32 , A61P37/06
CPC分类号： A61K31/519 , A61K31/145 , A61K31/436 , A61K38/13 , A61K45/06 , A61K2300/00
摘要： A medicine which effectively functions as an immunosuppressant or anti-inflammatory agent and is effective in diminishing the occurrence of side effects. The medicine comprises a combination of: a diaryl sulfide or diaryl ether compound having a 2-amino-1,3-propanediol structure and having the function of diminishing lymphocytes circulating through the periphery; and an immunosuppressant and/or an anti-inflammatory agent.
摘要翻译： 一种有效起免疫抑制剂或抗炎剂作用并有效减少副作用发生的药物。 该药物包括具有2-氨基-1,3-丙二醇结构的二芳基硫醚或二芳基醚化合物的组合，并具有减少淋巴细胞在周边循环的功能; 和免疫抑制剂和/或抗炎剂。
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5.发明申请EFFECTIVE USE METHOD OF MEDICAMENTS AND METHOD OF PREVENTING EXPRESSION OF SIDE EFFECT 有权有效使用药物的方法和防止侧面效应的表达方法公开(公告)号：US20100099606A1
公开(公告)日：2010-04-22
申请号：US12650899
申请日：2009-12-31
申请人： Shinji KUDOU , Kazuhiko Kuriyama , Tokutarou Yasue
发明人： Shinji KUDOU , Kazuhiko Kuriyama , Tokutarou Yasue
IPC分类号： A61K31/137 , A61P29/00 , A61P37/00 , A61K38/13 , A61K31/436
CPC分类号： A61K31/519 , A61K31/145 , A61K31/436 , A61K38/13 , A61K45/06 , A61K2300/00
摘要： To provide a medicament which efficiently expresses an immunosuppressive agent or an anti-inflammatory agent and reduces expression of side effect.A medicament includes diaryl sulfide or diaryl ether compound having a 2-amino-1,3-propanediol structure having an activity of reducing lymphocytes circulating peripherally, in combination with an immunosuppressive agent and/or an anti-inflammatory agent.
摘要翻译： 提供有效地表达免疫抑制剂或抗炎剂并减少副作用表达的药物。 药物包括与免疫抑制剂和/或抗炎剂组合的具有减少周围循环的淋巴细胞的活性的具有2-氨基-1,3-丙二醇结构的二芳基硫醚或二芳基醚化合物。
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6.发明申请Effective Use Method Of Medicaments And Method Of Preventing Expression Of Side Effect 有权药物有效使用方法及防止副作用表现的方法公开(公告)号：US20080032923A1
公开(公告)日：2008-02-07
申请号：US11631128
申请日：2005-07-15
申请人： Shinji Kudou , Kazuhiko Kuriyama , Tokutarou Yasue
发明人： Shinji Kudou , Kazuhiko Kuriyama , Tokutarou Yasue
IPC分类号： A61K31/133 , A61K31/343 , A61K31/4353 , A61K31/4985 , A61K38/13 , A61P37/00
CPC分类号： A61K31/519 , A61K31/145 , A61K31/436 , A61K38/13 , A61K45/06 , A61K2300/00
摘要： A medicine which effectively functions as an immunosuppressant or anti-inflammatory agent and is effective in diminishing the occurrence of side effects. The medicine comprises a combination of: a diaryl sulfide or diaryl ether compound having a 2-amino-1,3-propanediol structure and having the function of diminishing lymphocytes circulating through the periphery; and an immunosuppressant and/or an anti-inflammatory agent.
摘要翻译： 一种有效起免疫抑制剂或抗炎剂作用并有效减少副作用发生的药物。 该药物包括具有2-氨基-1,3-丙二醇结构的二芳基硫醚或二芳基醚化合物的组合，并具有减少淋巴细胞在周边循环的功能; 和免疫抑制剂和/或抗炎剂。
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7.发明申请THERAPEUTIC AGENT OR PROPHYLACTIC AGENT FOR DEMYELINATING DISEASE COMPRISING AMINO ALCOHOL DERIVATIVE AS ACTIVE INGREDIENT 审中-公开用于将包含氨基醇衍生物作为活性成分的疾病的治疗药物或预防剂公开(公告)号：US20100093745A1
公开(公告)日：2010-04-15
申请号：US12449517
申请日：2008-02-08
申请人： Kazuhiko Kuriyama , Tokutarou Yasue
发明人： Kazuhiko Kuriyama , Tokutarou Yasue
IPC分类号： A61K31/4965 , A61K31/095 , A61K31/235 , A61P25/28 , A61P21/00
CPC分类号： A61K31/137 , A61K31/095 , A61K31/235 , A61K31/4965
摘要： A novel therapeutic agent or prophylactic agent for a demyelinating disease is provided. An amino alcohol derivative represented by the general formula (1), which is a sphingosine-1-phosphate receptor agonist, a pharmacologically acceptable salt or hydrates thereof, are a therapeutic agent or prophylactic agent for a demyelinating disease.
摘要翻译： 提供了用于脱髓鞘疾病的新型治疗剂或预防剂。 由通式（1）表示的氨基醇衍生物，其为鞘氨醇-1-磷酸受体激动剂，其药理学上可接受的盐或其水合物，是脱髓鞘病的治疗剂或预防剂。
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公开(公告)号：US20090156653A1
公开(公告)日：2009-06-18
申请号：US12292609
申请日：2008-11-21
申请人： Yasushi Kohno , Kiyoaki Tanaka , Kazuhiko Kuriyama
发明人： Yasushi Kohno , Kiyoaki Tanaka , Kazuhiko Kuriyama
IPC分类号： A61K31/421 , C07C321/30 , C07D263/24 , A61K31/138 , A61P37/02 , C07C215/28 , A61K31/216
CPC分类号： C07C271/22 , C07C217/64 , C07C219/14 , C07C225/16 , C07C229/36 , C07C271/16 , C07C271/18 , C07C317/22 , C07C317/32 , C07C323/32 , C07C323/41 , C07C323/42 , C07C323/43 , C07C323/63
摘要： An amino alcohol derivative represented by the following general formula (1) (for example, (±)-2-amino-5-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-2-methylpentane-1-ol) exhibits strong immunosuppressive effect while causing less side effects:
摘要翻译： 由以下通式（1）表示的氨基醇衍生物（例如（±）-2-氨基-5- [4-（3-苄氧基苯硫基）-2-氯苯基] -2-甲基戊烷-1-醇）表现出 强的免疫抑制作用同时引起较少的副作用：
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公开(公告)号：US07482491B2
公开(公告)日：2009-01-27
申请号：US10528240
申请日：2003-09-16
申请人： Yasushi Kohno , Kiyoaki Tanaka , Kazuhiko Kuriyama
发明人： Yasushi Kohno , Kiyoaki Tanaka , Kazuhiko Kuriyama
IPC分类号： C07C215/00 , A61K31/00
CPC分类号： C07C271/22 , C07C217/64 , C07C219/14 , C07C225/16 , C07C229/36 , C07C271/16 , C07C271/18 , C07C317/22 , C07C317/32 , C07C323/32 , C07C323/41 , C07C323/42 , C07C323/43 , C07C323/63
摘要： An amino alcohol derivative represented by the following general formula (1) (for example, (±)-2-amino-5-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-2-methylpentane-1-ol) exhibits strong immunosuppressive effect while causing less side effects:
摘要翻译： 由以下通式（1）表示的氨基醇衍生物（例如（±）-2-氨基-5- [4-（3-苄氧基苯硫基）-2-氯苯基] -2-甲基戊烷-1-醇）表现出 强的免疫抑制作用同时引起较少的副作用：
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公开(公告)号：US20060135622A1
公开(公告)日：2006-06-22
申请号：US10528240
申请日：2003-09-16
申请人： Yasushi Kohno , Kiyoaki Tanaka , Kazuhiko Kuriyama
发明人： Yasushi Kohno , Kiyoaki Tanaka , Kazuhiko Kuriyama
IPC分类号： A61K31/137
CPC分类号： C07C271/22 , C07C217/64 , C07C219/14 , C07C225/16 , C07C229/36 , C07C271/16 , C07C271/18 , C07C317/22 , C07C317/32 , C07C323/32 , C07C323/41 , C07C323/42 , C07C323/43 , C07C323/63
摘要： An amino alcohol derivative represented by the following general formula (1) (for example, (±)-2-amino-5-[4-(3-benzyloxyphenylthio)-2-chlorophenyl]-2-methylpentane-1-ol) exhibits strong immunosuppressive effect while causing less side effects:
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