公开(公告)号：US20190091266A1

公开(公告)日：2019-03-28

申请号：US16198811

申请日：2018-11-22

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Yair Reisner ,  Carmit Hillel-Karniel ,  Chava Rosen ,  Esther Bachar-Lustig ,  Elias Shezen

IPC: A61K35/42 ,  A61K35/28 ,  A61K9/00 ,  A61P11/00

Abstract: A method of treating a pulmonary disorder or injury in a subject in need thereof is disclosed. The method comprising administering to the subject non-syngeneic pulmonary tissue cells in suspension comprising an effective amount of hematopoietic precursor cells (HPCs) or supplemented with HPCs, wherein the effective amount is a sufficient amount to achieve tolerance to the pulmonary tissue cells in the absence of chronic immunosuppressive regimen. A method of inducing donor specific tolerance in a subject in need of a pulmonary cell or tissue transplantation is also disclosed.