公开(公告)号：US20020142357A1

公开(公告)日：2002-10-03

申请号：US10120397

申请日：2002-04-12

Applicant: Yeda Research and Development Co., Ltd.

Inventor： David Wallach ,  Cord Brakebusch

IPC: G01N033/53 ,  G01N033/542 ,  A61K039/395 ,  C07K016/28

CPC classification number: G01N33/6863 ,  A61K38/00 ,  A61K38/46 ,  C07K14/7151 ,  C07K16/28 ,  C07K16/2878

Abstract: A method of modulating signal transduction and/or cleavage in Tumor Necrosis Factor Receptors (TNF-Rs) is provided. Peptides or other molecules may interact either with the receptor itself, or with effector proteins interacting with the receptor, thus modulating the normal functioning of the TNF-Rs. Such peptides or other molecules may be employed for prophylactic and therapeutic applications in TNF associated diseases.