公开(公告)号：US20150197810A1

公开(公告)日：2015-07-16

申请号：US14671848

申请日：2015-03-27

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran HORNSTEIN ,  Alon Chen ,  Irit Reichenstein ,  Anna Maria Emde

IPC: C12Q1/68 ,  C12N15/113

CPC classification number: C12Q1/6883 ,  A61K31/7088 ,  C12N15/113 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/156 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178

Abstract: A method of diagnosing Amyotrophic Lateral Sclerosis (ALS) is disclosed. The method comprising determining a level of miR-218 in a biological sample of a subject, wherein a down-regulation in the miR-218 is indicative of ALS in the subject.

Abstract translation: 公开了诊断肌萎缩性侧索硬化症（ALS）的方法。 该方法包括测定受试者生物样品中miR-218的水平，其中miR-218中的下调表示受试者中的ALS。

公开(公告)号：US10159670B2

公开(公告)日：2018-12-25

申请号：US14612034

申请日：2015-02-02

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eran Hornstein ,  Anna Maria Emde

IPC: A61K31/496 ,  A61K31/538 ,  A61K45/06

Abstract: A method of treating a cellular stress-related disease in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of an agent capable of enhancing processing of a pre-miRNA, thereby treating the cellular stress-related disease in the subject. Methods for treating motor neuron disease (MND) are also provided as well as pharmaceutical compositions.

公开(公告)号：US20150164891A1

公开(公告)日：2015-06-18

申请号：US14612034

申请日：2015-02-02

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Eran HORNSTEIN ,  Anna Maria Emde

IPC: A61K31/496 ,  A61K45/06

CPC classification number: A61K31/496 ,  A61K31/538 ,  A61K45/06

Abstract: A method of treating a cellular stress-related disease in a subject in need thereof is provided. The method comprising administering to the subject a therapeutically effective amount of an agent capable of enhancing processing of a pre-miRNA, thereby treating the cellular stress-related disease in the subject. Methods for treating motor neuron disease (MND) are also provided as well as pharmaceutical compositions.

Abstract translation: 提供了在有需要的受试者中治疗细胞应激相关疾病的方法。 该方法包括向受试者施用治疗有效量的能够增强pre-miRNA加工的试剂，从而治疗受试者的细胞应激相关疾病。 还提供了治疗运动神经元疾病（MND）的方法以及药物组合物。