公开(公告)号：US20170247468A1

公开(公告)日：2017-08-31

申请号：US15494585

申请日：2017-04-24

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Deborah FASS ,  Iris GROSSMAN ,  Tal ILANI ,  Assaf ALON

IPC: C07K16/40

CPC classification number: C07K16/40 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/1137 ,  C12N2310/14 ,  C12Y108/03002

Abstract: A method of inhibiting or preventing laminin assembly in a basement membrane is disclosed. The method comprising contacting a tissue with an agent which inhibits QSOX1 activity or expression, thereby inhibiting or preventing laminin assembly in the basement membrane.