公开(公告)号：US20170247468A1

公开(公告)日：2017-08-31

申请号：US15494585

申请日：2017-04-24

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Deborah FASS ,  Iris GROSSMAN ,  Tal ILANI ,  Assaf ALON

IPC: C07K16/40

CPC classification number: C07K16/40 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/33 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/1137 ,  C12N2310/14 ,  C12Y108/03002

Abstract: A method of inhibiting or preventing laminin assembly in a basement membrane is disclosed. The method comprising contacting a tissue with an agent which inhibits QSOX1 activity or expression, thereby inhibiting or preventing laminin assembly in the basement membrane.

公开(公告)号：US20210147575A1

公开(公告)日：2021-05-20

申请号：US17087765

申请日：2021-02-07

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Deborah FASS ,  Iris GROSSMAN ,  Tal ILANI

IPC: C07K16/40 ,  A61K39/395 ,  C07K16/18

Abstract: An antibody comprising an antigen recognition domain exhibiting species cross reactivity to human QSOX1 and murine QSOX1 is disclosed. Methods of producing the antibody, pharmaceutical compositions comprising the antibody and methods of using the antibody for treating medical conditions are also disclosed.