公开(公告)号：US20190314312A1

公开(公告)日：2019-10-17

申请号：US16316639

申请日：2017-07-11

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Ayelet EREZ ,  Noa STETTNER

IPC: A61K31/198 ,  A61K31/366 ,  A61P1/00 ,  A61P35/00

Abstract: Provided are uses of a therapeutically effective amount of citrulline for the manufacture of a medicament for treatment of a subject having an inflammatory bowel disease (IBD) and/or colon cancer. Also provided are pharmaceutical compositions comprising a therapeutic effective amount of citrulline and a therapeutically effective amount of a flavonoid for the treatment of an inflammatory bowel disease (IBD) and/or colon cancer and kits comprising same.

公开(公告)号：US20230293530A1

公开(公告)日：2023-09-21

申请号：US18012260

申请日：2020-06-24

Applicant: Yeda Research and Development Co. Ltd. ,  The United States of America, as Represented by the Secretary, Department of Health and Human Servic

Inventor： Ayelet EREZ ,  Rom KESHET ,  Lital ADLER ,  Eytan RUPPIN ,  Lee Joo SANG

IPC: A61K31/519 ,  A61K31/235 ,  A61K31/18 ,  A61P35/00

CPC classification number: A61K31/519 ,  A61K31/18 ,  A61K31/235 ,  A61P35/00

Abstract: An agent which increases pyrimidine to purine ration in a cell without decreasing pyrimidine synthesis for use in a method of treating a solid tumor in a subject in need thereof, optionally in combination with an immune-modulating drug.

公开(公告)号：US20250057985A1

公开(公告)日：2025-02-20

申请号：US18933233

申请日：2024-10-31

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD. ,  TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED

Inventor： Ayelet EREZ ,  Omer GOLDMAN ,  Emma HAJAJ ,  Avi SCHROEDER

IPC: A61K48/00 ,  A61K38/17 ,  A61P35/00 ,  C07K16/24

Abstract: Methods of predicting clinical outcome in a subject suffering from cancer, detecting non-liver cancer in a subject, and methods of treating or preventing cancer or cancer-associated cachexia are provided. Synthetic lipid nanoparticles encapsulating an mRNA encoding for HNF4A and composition comprising same are also provided.

公开(公告)号：US20200150125A1

公开(公告)日：2020-05-14

申请号：US16487849

申请日：2018-03-12

Applicant: Yeda Research and Development Co., Ltd.

Inventor： Ayelet EREZ

IPC: G01N33/574

Abstract: Methods of diagnosing cancer are provided. Accordingly there is provided a method of diagnosing cancer in a subject, the method comprising determining a level of urea and/or a pyrimidine synthesis metabolite in a biological sample of the subject, wherein a level of urea below a predetermined threshold; and/or a said level of pyrimidine synthesis metabolite above a predetermined threshold; is indicative of cancer. Also provided are methods of prognosing and treating cancer.

公开(公告)号：US20180161300A1

公开(公告)日：2018-06-14

申请号：US15571071

申请日：2016-05-10

Applicant: Yeda Research And Development Co. Ltd.

Inventor： Ayelet EREZ ,  Shiran RABINOVICH ,  Alon SILBERMAN ,  Shani AGRON

IPC: A61K31/216 ,  A61P35/00 ,  A61K31/713 ,  A61K31/513 ,  C12N15/113 ,  A61K45/06

CPC classification number: A61K31/216 ,  A61K31/198 ,  A61K31/513 ,  A61K31/713 ,  A61K45/06 ,  A61P35/00 ,  C12N15/113 ,  C12N2310/14 ,  C12N2310/531

Abstract: Provided are methods, pharmaceutical compositions and kits for treating cancer in a subject in need thereof, by administering to the subject a therapeutically effective amount of an agent which downregulates a mitochondrial aspartate-dependent pyrimidine synthesis, thereby treating the cancer.