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1.发明申请Isolated CDNA encoding tumor necrosis factor binding protein II, its purification, and vectors, hosts and processes using such cDNA 有权分离的CDNA编码肿瘤坏死因子结合蛋白II，其纯化，以及使用这种cDNA的载体，宿主和过程公开(公告)号：US20030124675A1
公开(公告)日：2003-07-03
申请号：US10319536
申请日：2002-12-16
Applicant: Yeda Research and Development Co. Ltd.
Inventor： David Wallach , Hartmut Engelmann , Dan Aderka , Daniela Novick , Menachem Rubinstein
IPC: C12P021/02 , C12N005/06 , C07K016/24 , C07H021/04
CPC classification number: C07K16/2866 , A61K38/00 , C07K14/7151
Abstract: Tumor Necrosis Factor (TNF) Binding Protein is isolated and substantially purified. It has the ability to inhibit the cytotoxic effect of TNF and/or to maintain its prolonged beneficial effects. Isolated cDNA encoding TNF Binding Protein II is obtained and may be used to produce expression vectors, prokaryotic or eukaryotic expression hosts and methods of obtaining the protein by culturing of such hosts.
Abstract translation: 肿瘤坏死因子（TNF）结合蛋白被分离并基本纯化。 它具有抑制TNF的细胞毒性作用和/或维持其延长的有益效果的能力。 获得编码TNF结合蛋白II的分离的cDNA，并可用于产生表达载体，原核或真核表达宿主以及通过培养这些宿主获得蛋白质的方法。
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