公开(公告)号：US20040142860A1

公开(公告)日：2004-07-22

申请号：US09814699

申请日：2001-03-23

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Michal Eisenbach-Schwartz ,  Pierre Beserman ,  David L. Hirschberg

IPC: A61K038/17 ,  C07K014/74

CPC classification number: C07K5/06104 ,  A61K38/00 ,  C07K4/12 ,  Y02A50/465

Abstract: The present invention is directed to a central nervous system-derived heat stable immune privilege factor which exerts an inhibitory effect on macrophage migration and/or macrophage phagocytic activity. In addition, the factor exerts an inhibitory effect on the ability of macrophages and T cells to adhere to extracellular matrix and/or fibronectin. The invention is also directed to the isolation and methods for use of this immune privilege factor for the inhibition of inflammation in the central nervous system generally and at specific lesions in the central nervous system.

Abstract translation: 本发明涉及对巨噬细胞迁移和/或巨噬细胞吞噬活性具有抑制作用的中枢神经系统衍生的热稳定免疫特异性因子。 此外，该因子对巨噬细胞和T细胞粘附于细胞外基质和/或纤连蛋白的能力产生抑制作用。 本发明还涉及使用这种免疫特权因子来抑制中枢神经系统中的中枢神经系统炎症和中枢神经系统特定病变的分离和方法。