公开(公告)号：US20240009315A1

公开(公告)日：2024-01-11

申请号：US18229224

申请日：2023-08-02

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Gideon SCHREIBER ,  Jiri ZAHRADNIK ,  Amnon BAR-SHIR ,  Yinon RUDICH ,  Andrea GALISOVA

IPC: A61K47/64 ,  A61K47/69

CPC classification number: A61K47/64 ,  A61K47/6911

Abstract: Particles having an ACE2 targeting moiety attached to an outer surface thereof are disclosed herein. The ACE2 targeting moiety comprises a polypeptide comprising an amino acid sequence of SARS CoV-2 receptor-binding domain (RBD), wherein said amino acid sequence comprises a modification at position 358 and at least two additional modifications at two positions selected from the group consisting of 484, 498 and 501. Uses of the particles for treatment and diagnosis of diseases are also disclosed.

公开(公告)号：US20230263884A1

公开(公告)日：2023-08-24

申请号：US18122169

申请日：2023-03-16

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Gideon SCHREIBER ,  Jiri ZAHRADNIK ,  Yinon RUDICH

IPC: A61K39/215 ,  C07K14/005

CPC classification number: A61K39/215 ,  C07K14/005 ,  A61K38/00

Abstract: A polypeptide comprising an amino acid sequence of SARS CoV-2 receptor-binding domain (RBD) is disclosed, wherein said amino acid sequence comprises a modification at position 358 and at least two additional modifications at two positions selected from the group consisting of 484, 498 and 501, wherein the polypeptide binds soluble, monomeric angiotensin-converting enzyme 2 (ACE2) receptor. Uses thereof are further disclosed.