公开(公告)号：US20200306343A1

公开(公告)日：2020-10-01

申请号：US16891165

申请日：2020-06-03

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eldad TZAHOR ,  Kfir Baruch UMANSKY ,  Rabea HINKEL ,  Christian KUPATT

IPC: A61K38/17 ,  A61P9/10

Abstract: A method of treating an ischemic heart disease in a subject in need thereof is provided. The method comprises administering to the subject a therapeutically effective amount of Agrin in an anterograde intracoronary manner, thereby treating the ischemic heart disease in the subject.

公开(公告)号：US20160326250A1

公开(公告)日：2016-11-10

申请号：US15147178

申请日：2016-05-05

Applicant: Yeda Research and Development Co. Ltd. ,  Victor Chang Cardiac Research Institute

Inventor： Eldad TZAHOR ,  Gabriele Matteo D'UVA ,  Rachel SARIG ,  Alla AHARONOV ,  Richard Paul HARVEY ,  Kfir Baruch UMANSKY

IPC: C07K16/28 ,  A61K39/395 ,  G01N33/50 ,  A61K38/18

CPC classification number: C07K16/2863 ,  A61K9/00 ,  A61K31/7115 ,  A61K38/1709 ,  A61K38/1825 ,  A61K38/1883 ,  A61K39/3955 ,  C07K2317/75 ,  G01N33/5023 ,  G01N33/5061 ,  A61K2300/00

Abstract: A method of potentiating cardiac regeneration with neuregulin treatment in a subject in need thereof. The method comprising administering to the subject a therapeutic effective amount of an agent which upregulates activity or expression of ErbB-2, thereby potentiating cardiac regeneration with neuregulin treatment.

Abstract translation: 在有需要的受试者中用神经调节蛋白处理增强心脏再生的方法。 该方法包括向受试者施用治疗有效量的上调ErbB-2的活性或表达的试剂，从而通过神经调节蛋白处理增强心脏再生。