公开(公告)号：US20200306343A1

公开(公告)日：2020-10-01

申请号：US16891165

申请日：2020-06-03

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eldad TZAHOR ,  Kfir Baruch UMANSKY ,  Rabea HINKEL ,  Christian KUPATT

IPC: A61K38/17 ,  A61P9/10

Abstract: A method of treating an ischemic heart disease in a subject in need thereof is provided. The method comprises administering to the subject a therapeutically effective amount of Agrin in an anterograde intracoronary manner, thereby treating the ischemic heart disease in the subject.

公开(公告)号：US20240042104A1

公开(公告)日：2024-02-08

申请号：US18368332

申请日：2023-09-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eldad TZAHOR ,  Elad BASSAT

IPC: A61L27/54 ,  C12N5/077 ,  A61K38/17 ,  A61P9/10 ,  C07K14/47

CPC classification number: A61L27/54 ,  C12N5/0657 ,  A61K38/1709 ,  A61P9/10 ,  C07K14/4725 ,  A61L2300/252 ,  C12N2501/998

Abstract: An Agrin peptide which induces proliferation of cardiomyocytes for treating a heart disease is provided.

公开(公告)号：US20160326250A1

公开(公告)日：2016-11-10

申请号：US15147178

申请日：2016-05-05

Applicant: Yeda Research and Development Co. Ltd. ,  Victor Chang Cardiac Research Institute

Inventor： Eldad TZAHOR ,  Gabriele Matteo D'UVA ,  Rachel SARIG ,  Alla AHARONOV ,  Richard Paul HARVEY ,  Kfir Baruch UMANSKY

IPC: C07K16/28 ,  A61K39/395 ,  G01N33/50 ,  A61K38/18

CPC classification number: C07K16/2863 ,  A61K9/00 ,  A61K31/7115 ,  A61K38/1709 ,  A61K38/1825 ,  A61K38/1883 ,  A61K39/3955 ,  C07K2317/75 ,  G01N33/5023 ,  G01N33/5061 ,  A61K2300/00

Abstract: A method of potentiating cardiac regeneration with neuregulin treatment in a subject in need thereof. The method comprising administering to the subject a therapeutic effective amount of an agent which upregulates activity or expression of ErbB-2, thereby potentiating cardiac regeneration with neuregulin treatment.

Abstract translation: 在有需要的受试者中用神经调节蛋白处理增强心脏再生的方法。 该方法包括向受试者施用治疗有效量的上调ErbB-2的活性或表达的试剂，从而通过神经调节蛋白处理增强心脏再生。

公开(公告)号：US20240074473A1

公开(公告)日：2024-03-07

申请号：US18387165

申请日：2023-11-06

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Eldad TZAHOR ,  Ori PORAT-AVINOAM ,  Tamar Miriam Rose EIGLER-HIRSH

IPC: A23L13/40 ,  C12N5/077

CPC classification number: A23L13/45 ,  C12N5/0658 ,  C12N2500/14 ,  C12N2501/50 ,  C12N2501/727 ,  C12N2510/00

Abstract: A method of inducing multinucleated myotube formation is provided. The method comprising contacting myogenic precursor cells from a farmed animal with an Extracellular Regulated Signaling Kinase (ERK1/2) inhibitor and/or an upregulator of intracellular Ca 2+ and/or RXR/RAR agonists, enhancing fusion and myogenic maturation.

公开(公告)号：US20180318612A1

公开(公告)日：2018-11-08

申请号：US15772065

申请日：2016-10-27

Applicant: Yeda Research and Development Co., Ltd.,

Inventor： Eldad TZAHOR ,  Elad BASSAT

IPC: A61P9/10 ,  C12N5/077 ,  C07K14/47

CPC classification number: A61P9/10 ,  A61K38/1709 ,  A61L27/54 ,  A61L2300/252 ,  C07K14/4725 ,  C12N5/0657 ,  C12N2501/998

Abstract: An Agrin peptide which induces proliferation of cardiomyocytes for treating a heart disease is provided.