公开(公告)号：US11834678B2

公开(公告)日：2023-12-05

申请号：US16762164

申请日：2018-11-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Idit Shachar ,  Shirly Herman

IPC: C12N5/0789 ,  C07K16/28 ,  A61K39/395 ,  A61K45/06 ,  A61K35/28

CPC classification number: C12N5/0647 ,  A61K35/28 ,  A61K39/3955 ,  A61K45/06 ,  C07K16/2833 ,  C12N2501/998

Abstract: A method of generating hematopoietic stem cells for transplantation is disclosed. The method comprising: (a) collecting hematopoietic stem cells; and (b) contacting the hematopoietic stem cells with an agent capable of decreasing an activity or expression of CD74 and/or of macrophage migration inhibitory factor (MIF), to thereby generate hematopoietic stem cells for transplantation, and wherein the hematopoietic stem cells are not transduced with a lentivirus. Methods of increasing mobilization of hematopoietic stem cells and methods of treatment are also provided.