公开(公告)号：US20230132790A1

公开(公告)日：2023-05-04

申请号：US17915500

申请日：2021-03-29

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Anthony H. FUTERMAN ,  Israel SILMAN ,  Joel L. SUSSMAN ,  Sarel FLEISHMAN ,  Adi GOLDENZWEIG ,  Sarka POKORNA ,  Yaacov ASHANI ,  Olga KHERSONSKY

IPC: C12N9/24

Abstract: A genetically modified human beta-glucocerebrosidase (GCase) is disclosed. The genetically modified GCase comprising an amino acid sequence at least 85% identical to SEQ ID NO: 2; and comprising mutations at coordinates L34P, K224N/G, T369E and N370D, where the coordinates correspond to said SEQ ID NO: 2; and capable of catalyzing hydrolysis of a glycolipid glucosylceramide (GlcCer). Pharmaceutical compositions comprising the genetically modified GCase and therapeutic methods of using same are also disclosed.

公开(公告)号：US20190083836A1

公开(公告)日：2019-03-21

申请号：US15535050

申请日：2015-12-10

Applicant: Yeda Research and Development Co, Ltd ,  University of Washington

Inventor： Dan S. TAWFIK ,  Haim LEADER ,  Yaacov ASHANI ,  Izhack CHERNY ,  Moshe GOLDSMITH ,  Per Jr. GRIESEN ,  Sagar D KHARE ,  Gustav Oberdorfer ,  David Baker ,  Sarel Fleishman ,  Adi Goldenzweig ,  Nidhi Aggarwal

IPC: A62D3/02 ,  C12N9/16 ,  A61P25/00

CPC classification number: A62D3/02 ,  A61P25/00 ,  A62D2101/02 ,  A62D2101/26 ,  C12N9/16 ,  C12Y301/08001

Abstract: A genetically modified polypeptide is disclosed which comprises an amino acid sequence of phosphotriesterase (PTE) having at least twice the catalytic efficiency for a V-type nerve agent as a polypeptide which consists of the sequence as set forth in SEQ ID NO: 1, when assayed under identical conditions.