利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

354 条记录 (耗时 0.027 秒)

    Processing venous oxygen saturation and hematocrit information in an implantable sensor
    1.
    发明授权
    Processing venous oxygen saturation and hematocrit information in an implantable sensor 有权
    在植入式传感器中处理静脉血氧饱和度和血细胞比容信息

    公开(公告)号：US08385999B1

    公开(公告)日：2013-02-26

    申请号：US12028261

    申请日：2008-02-08

    申请人： Yelena Nabutovsky ,  Gene A. Bornzin ,  Taraneh Ghaffari Farazi ,  John W. Poore

    发明人： Yelena Nabutovsky ,  Gene A. Bornzin ,  Taraneh Ghaffari Farazi ,  John W. Poore

    IPC分类号： A61B5/00

    CPC分类号： A61N1/39 ,  A61B5/0031 ,  A61B5/14535 ,  A61B5/14551 ,  A61B5/4836 ,  A61N1/362

    摘要： Methods of processing venous oxygen saturation and hematrocrit information in an implantable sensor are provided. In an embodiment a method for collecting data from an implantable multi-wavelength SvO2 sensor having multiple light sources is provided. The method includes receiving a frame signal that indicates a beginning of the light sources being turned on and receiving a light source signal that indicates a light source is on. The output of a photodetector is sampled to measure the intensity of the transmitted light. The process is repeated for each light source to gather intensity measurements that then can be used to generate venous oxygen saturation and hematocrit measurements.

    摘要翻译： 提供了在可植入传感器中处理静脉血氧饱和度和血细胞信息的方法。 在一个实施例中，提供了一种用于从具有多个光源的可植入多波长SvO2传感器收集数据的方法。 该方法包括接收指示光源开始接通的帧信号，并接收指示光源所接通的光源信号。 对光检测器的输出进行采样以测量透射光的强度。 对于每个光源重复该过程以收集强度测量，然后可以使用该测量来产生静脉血氧饱和度和血细胞比容测量。

    Calibrating implantable optical sensors
    2.
    发明授权
    Calibrating implantable optical sensors 失效
    校准植入光学传感器

    公开(公告)号：US07630078B1

    公开(公告)日：2009-12-08

    申请号：US11683521

    申请日：2007-03-08

    申请人： Yelena Nabutovsky ,  Gene A. Bornzin ,  Taraneh Ghaffari Farazi ,  John W. Poore

    发明人： Yelena Nabutovsky ,  Gene A. Bornzin ,  Taraneh Ghaffari Farazi ,  John W. Poore

    IPC分类号： G01B9/08

    CPC分类号： A61B5/14542 ,  A61B5/02028 ,  A61B5/14535 ,  A61B5/1459 ,  A61B2560/0223 ,  A61N1/36557

    摘要： A measurement light detector detects light transmitted by a light source of an implantable system that is scattered back into an implantable housing, and produces a measurement signal indicative of the intensity of the light detected by the measurement light detector. A calibration light detector detects a portion of the transmitted light that has not exited the housing, and produces a calibration signal that is indicative of the intensity of the light detected by the calibration light detector, which is indicative of the intensity of the light transmitted by the light source. Changes in the intensity of the transmitted light are compensated for based on the calibration signal produced by the calibration light detector. This description is not intended to be a complete description of, or limit the scope of, the invention. Other features, aspects, and objects of the invention can be obtained from a review of the specification, the figures, and the claims.

    摘要翻译： 测量光检测器检测由可植入系统的光源透射的光，其被散射回到可植入的壳体中，并且产生指示由测量光检测器检测到的光的强度的测量信号。 校准光检测器检测未离开壳体的透射光的一部分，并且产生指示由校准光检测器检测的光的强度的校准信号，该校准信号指示由光学器件发射的光的强度 光源。 基于由校准光检测器产生的校准信号来补偿透射光强度的变化。 本说明书不是对本发明的完整描述或限制本发明的范围。 本发明的其它特征，方面和目的可以通过对说明书，附图和权利要求的评述来获得。

    Implantable multi-wavelength venous oxygen saturation and hematocrit sensor and method
    3.
    发明授权
    Implantable multi-wavelength venous oxygen saturation and hematocrit sensor and method 有权
    可植入多波长静脉血氧饱和度和血细胞比容传感器及方法

    公开(公告)号：US08175668B1

    公开(公告)日：2012-05-08

    申请号：US11877056

    申请日：2007-10-23

    申请人： Yelena Nabutovsky ,  Gene A. Bornzin ,  Taraneh Ghaffari Farazi ,  John W. Poore

    发明人： Yelena Nabutovsky ,  Gene A. Bornzin ,  Taraneh Ghaffari Farazi ,  John W. Poore

    IPC分类号： A61B5/1455

    CPC分类号： A61B5/14552 ,  A61B5/1459 ,  A61N1/36557

    摘要： An intravenous implantable optical sensor assesses the relative absorbance of multiple wavelengths of light in order to determine oxygen saturation. The calculation of oxygen saturation is enhanced by use of a function of hematocrit which is derived from the relative absorbance of light of an isobestic wavelength along two different length paths through the blood. The use of the hematocrit-dependent term and multiple wavelengths of light to calculate oxygen saturation provides results that are less susceptible to noise and variation in hematocrit and thus provides a more accurate measure of oxygen saturation over a wider range of conditions than previously possible. The optical sensor may form part of an implantable system which performs the calculation of oxygen saturation and uses the results for a diagnostic or therapeutic purpose.

    摘要翻译： 静脉注射光学传感器评估多个波长的光的相对吸光度以确定氧饱和度。 通过使用血细胞比容的功能来提高氧饱和度的计算，血细胞比容的功能来源于通过血液的两条不同长度路径的异质波长的光的相对吸光度。 使用血细胞比容相关术语和多个波长的光来计算氧饱和度提供的结果不太容易受噪声和血细胞比容的变化，因此在比以前可能的更宽的条件下提供更准确的氧饱和度测量。 光学传感器可以形成可执行氧饱和度的计算的可植入系统的一部分，并将结果用于诊断或治疗目的。

    Monitoring heart disease using implantable sensors and slopes determined therefrom
    5.
    发明授权
    Monitoring heart disease using implantable sensors and slopes determined therefrom 有权
    使用由其确定的可植入传感器和斜坡来监测心脏病

    公开(公告)号：US08170664B1

    公开(公告)日：2012-05-01

    申请号：US11931165

    申请日：2007-10-31

    申请人： Yelena Nabutovsky ,  Kyungmoo Ryu ,  Taraneh Ghaffari Farazi ,  Gene A. Bornzin

    发明人： Yelena Nabutovsky ,  Kyungmoo Ryu ,  Taraneh Ghaffari Farazi ,  Gene A. Bornzin

    IPC分类号： A61N1/37 ,  A61N1/08

    CPC分类号： A61N1/3627 ,  A61N1/36521 ,  A61N1/36557 ,  A61N1/36564 ,  A61N1/36578 ,  A61N1/3702

    摘要： Specific embodiments of the present invention use an implanted sensor, during a period of time, to measure a physiologic property when the patient's heart is not stressed, and when the patient's heart is stressed. A slope is determined, where the slope is indicative of a change in the physiologic property during the period of time. Heart disease is monitored based on a magnitude of the slope. In further embodiments of the present invention, a slope indicative of a change in a physiologic property during a period of time is determined, for each of a plurality of periods of time. Changes in the patient's heart disease are monitored based on changes in the slope.

    摘要翻译： 本发明的具体实施例在一段时间内使用植入式传感器来测量当患者的心脏没有受到压力时以及当患者的心脏被压力时的生理特性。 确定斜率，其中斜率表示在一段时间内生理特性的变化。 基于斜率的大小来监测心脏病。 在本发明的另外的实施例中，对于多个时间段中的每一个确定指示在一段时间内的生理特性变化的斜率。 根据斜率的变化监测患者心脏病变化。

    Systems and methods for increasing implantable sensor accuracy
    8.
    发明授权
    Systems and methods for increasing implantable sensor accuracy 有权
    增加植入式传感器精度的系统和方法

    公开(公告)号：US07920913B1

    公开(公告)日：2011-04-05

    申请号：US11771514

    申请日：2007-06-29

    申请人： Yelena Nabutovsky ,  Gene A. Bornzin ,  Kyungmoo Ryu ,  Taraneh Ghaffari Farazi

    发明人： Yelena Nabutovsky ,  Gene A. Bornzin ,  Kyungmoo Ryu ,  Taraneh Ghaffari Farazi

    IPC分类号： A61B5/04

    CPC分类号： A61B5/14551 ,  A61B2560/02

    摘要： Provided herein are implantable systems, and methods for use therewith, that increase the accuracy of measurements produced using an implanted sensor, where the measurements are affected by cycles of a cyclical body function (e.g., heart beat and/or respiration). In accordance with specific embodiments of system, a measurement that is presumed to be accurate is obtained. The measurement can be of a physiologic property, such as, but not limited to, blood oxygen saturation, hematocrit, or blood glucose concentration. Additionally, the implanted is used to produce a plurality of measurements of the physiologic property. Such measurements, produced using the implanted sensor, are compared to the measurement presumed to be accurate to thereby identify when the measurements produced using the implanted sensor are most accurate. Thereafter, the implanted system is configured to use the implanted sensor to produce measurements when the measurements produced using the implanted sensor are most accurate.

    摘要翻译： 本文提供了可植入系统及其使用的方法，其增加使用植入式传感器产生的测量的精度，其中测量受周期性身体功能（例如心跳和/或呼吸）的周期的影响。 根据系统的具体实施例，获得推测为准确的测量值。 测量可以具有生理特性，例如但不限于血氧饱和度，血细胞比容或血糖浓度。 另外，植入用于产生生理特性的多个测量。 将使用植入的传感器产生的这种测量与推定为准确的测量进行比较，从而识别何时使用植入的传感器产生的测量是最准确的。 此后，当使用植入的传感器产生的测量最准确时，植入系统被配置为使用植入的传感器来产生测量。

    Motion detection for sensors sensitive to motion induced noise
    9.
    发明授权
    Motion detection for sensors sensitive to motion induced noise 有权
    对运动感应噪声敏感的传感器的运动检测

    公开(公告)号：US07725187B1

    公开(公告)日：2010-05-25

    申请号：US11556905

    申请日：2006-11-06

    申请人： Yelena Nabutovsky ,  Taraneh Ghaffari Farazi ,  Gene A. Bornzin

    发明人： Yelena Nabutovsky ,  Taraneh Ghaffari Farazi ,  Gene A. Bornzin

    IPC分类号： A61N1/08

    CPC分类号： A61B5/14542 ,  A61B5/02416 ,  A61B5/1459 ,  A61B5/7207

    摘要： Provided herein are implantable systems, and methods for use therewith, for estimating a level of noise in a signal produced by an implantable sensor that is sensitive to motion induced noise. Sample data is obtained that is representative of a window of a signal produced by the implantable sensor that is sensitive to motion induced noise. Such sample data includes a plurality of samples each having a magnitude (e.g., amplitude). Each of at least some of the samples is assigned to one of a plurality of bins based on the magnitude of the sample, wherein each bin corresponds to a different range of magnitudes. The plurality of bins includes at least a low bin defining a lowest magnitude range and a high bin defining a highest magnitude range. A level of motion induced noise in the sensor signal is estimated based on a distribution of the samples to the bins.

    摘要翻译： 本文提供了可植入系统及其使用的方法，用于估计由可移动传感器产生的对运动引起的噪声敏感的信号中的噪声水平。 获得代表由可植入传感器产生的对运动引起的噪声敏感的信号的窗口的样本数据。 这样的样本数据包括多个具有幅度（例如振幅）的样本。 基于样本的大小将至少一些样本中的每一个分配给多个箱中的一个，其中每个箱对应于不同的幅度范围。 多个箱包括至少限定最低幅度范围的低仓和限定最大幅度范围的高仓。 传感器信号中的运动引起的噪声水平是根据样本到箱的分布来估计的。