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公开(公告)号:US20120149715A1
公开(公告)日:2012-06-14
申请号:US13149059
申请日:2011-05-31
申请人: Yi Tsun Richard Kao , Kwok-Yung Yuen , Dan Yang , Lihong Hu , Guanhua Chen , Bo-Jian Zheng
发明人: Yi Tsun Richard Kao , Kwok-Yung Yuen , Dan Yang , Lihong Hu , Guanhua Chen , Bo-Jian Zheng
IPC分类号: A61K31/496 , G06G7/48 , A61P31/16 , C07D413/06 , A61P31/12
CPC分类号: G16B5/00 , A61K31/496 , C07D261/04 , G01N33/5032 , G01N33/5035 , G01N33/6875 , G01N2333/11 , G01N2500/20
摘要: High throughput and virtual screening methods are disclosed that can identify potential anti-viral agents. The virtual screening methods identify agents that interact with a viral nucleoprotein binding site. The high throughput methods identify compounds that inhibit viral infection by binding to viral nucleoprotein. Also disclosed are pharmaceutical formulations useful for treating or preventing viral infections, especially influenza A.
摘要翻译: 公开了高通量和虚拟筛选方法,其可以鉴定潜在的抗病毒剂。 虚拟筛选方法鉴定与病毒核蛋白结合位点相互作用的试剂。 高通量方法通过结合病毒核蛋白鉴定抑制病毒感染的化合物。 还公开了可用于治疗或预防病毒感染,特别是甲型流感的药物制剂。
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公开(公告)号:US20110212975A1
公开(公告)日:2011-09-01
申请号:US12850806
申请日:2010-08-05
申请人: Yi Tsun Richard Kao , Dan Yang , Kwok-Yung Yuen
发明人: Yi Tsun Richard Kao , Dan Yang , Kwok-Yung Yuen
IPC分类号: A61K31/496 , C07D413/06 , A61P31/16
CPC分类号: C07D413/06 , A61K31/496
摘要: Compounds which exhibit antiviral activity, particularly against influenza virus, and methods of making and using thereof are described herein. In one embodiment, the compounds are heterocyclic amides containing piperazine and isozazole rings and optionally substituted with one or more substituents. The compounds can be formulated with one or more pharmaceutically acceptable excipients to form compositions suitable for enteral or parenteral administration. The compounds are preferably used to treat or prevent Influenza A infections, such as H1N1, H2N2, H3N2, H5N1, H7N7, H1N2, H9N2, H7N2, H7N3, and H10N7.
摘要翻译: 本文描述了显示抗病毒活性,特别是针对流感病毒的化合物及其制备和使用方法。 在一个实施方案中,化合物是含有哌嗪和异唑环并任选被一个或多个取代基取代的杂环酰胺。 可以将化合物与一种或多种药学上可接受的赋形剂配制以形成适于肠内或肠胃外给药的组合物。 该化合物优选用于治疗或预防甲型流感感染,如H1N1,H2N2,H3N2,H5N1,H7N7,H1N2,H9N2,H7N2,H7N3和H10N7。
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公开(公告)号:US09212177B2
公开(公告)日:2015-12-15
申请号:US12850806
申请日:2010-08-05
申请人: Yi Tsun Richard Kao , Dan Yang , Kwok-Yung Yuen
发明人: Yi Tsun Richard Kao , Dan Yang , Kwok-Yung Yuen
IPC分类号: A61K31/496 , C07D413/06
CPC分类号: C07D413/06 , A61K31/496
摘要: Compounds which exhibit antiviral activity, particularly against influenza virus, and methods of making and using thereof are described herein. In one embodiment, the compounds are heterocyclic amides containing piperazine and isozazole rings and optionally substituted with one or more substituents. The compounds can be formulated with one or more pharmaceutically acceptable excipients to form compositions suitable for enteral or parenteral administration. The compounds are preferably used to treat or prevent Influenza A infections, such as H1N1, H2N2, H3N2, H5N1, H7N7, H1N2, H9N2, H7N2, H7N3, and H10N7.
摘要翻译: 本文描述了显示抗病毒活性,特别是针对流感病毒的化合物及其制备和使用方法。 在一个实施方案中,化合物是含有哌嗪和异唑环并任选被一个或多个取代基取代的杂环酰胺。 可以将化合物与一种或多种药学上可接受的赋形剂配制以形成适于肠内或肠胃外给药的组合物。 该化合物优选用于治疗或预防甲型流感感染,如H1N1,H2N2,H3N2,H5N1,H7N7,H1N2,H9N2,H7N2,H7N3和H10N7。
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公开(公告)号:US20120142701A1
公开(公告)日:2012-06-07
申请号:US13149056
申请日:2011-05-31
IPC分类号: A61K31/496 , A61P31/12 , A61P31/04 , G01N33/566 , A61P31/16 , G01N33/53 , C12Q1/68 , C07D417/06 , A61P35/00
CPC分类号: G16B5/00 , A61K31/496 , C07D261/04 , G01N33/5032 , G01N33/5035 , G01N33/6875 , G01N2333/11 , G01N2500/20
摘要: Cell-based and cell-free assays are disclosed that detect compounds that promote aggregation of proteins, glycoproteins, and protein-nucleic acid complexes. Also disclosed are pharmaceutical formulations useful for treating or preventing viral infections, bacterial infections, cancer, and diseases involving hyper-proliferative cells.
摘要翻译: 公开了基于细胞和无细胞的测定,其检测促进蛋白质,糖蛋白和蛋白质 - 核酸复合物聚集的化合物。 还公开了可用于治疗或预防病毒感染,细菌感染,癌症和涉及超增殖细胞的疾病的药物制剂。
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