公开(公告)号：US5961482A

公开(公告)日：1999-10-05

申请号：US617688

申请日：1996-03-19

申请人： Yie W. Chien ,  John Kong-Jiann Li ,  Jue-Chen Liu ,  Wei-Min Shi ,  Ovais Siddiqui ,  Ying Sun

发明人： Yie W. Chien ,  John Kong-Jiann Li ,  Jue-Chen Liu ,  Wei-Min Shi ,  Ovais Siddiqui ,  Ying Sun

IPC分类号： A61K9/00 ,  A61N1/30 ,  A61N1/32

CPC分类号： A61N1/044 ,  A61K9/0009 ,  A61N1/303 ,  A61N1/325 ,  A61N1/0432

摘要： This invention relates to development of an iontotherapeutic device for regulated transdermal systemic administration of ionizable pharmaceutical compounds. It also provides an iontotherapeutic process for transdermal administration of ionized pharmaceuticals, particularly those which are otherwise transdermally absorbed to a small degree or not all, such as peptide pharmaceuticals, for example, insulins. The invention also relates to unit dose forms, for example, those in which an ionized pharmaceutical is dispersed in a hydrophilic polymer. The unit dose is adapted to be assembled as part of the pharmaceutical reservoir electrode, so that the ionized pharmaceutical will be delivered transdermally and then be absorbed systemically when the iontotherapeutic device is in operation.

摘要翻译： 本发明涉及用于可调节药物化合物的经调理的经皮系统给药的离子治疗装置的开发。 它还提供离子治疗方法，用于经皮给药离子化药物，特别是那些在很小程度上经皮吸收的药物，例如肽药物，例如胰岛素。 本发明还涉及单位剂量形式，例如其中离子化药物分散在亲水性聚合物中的那些形式。 单位剂量适于作为药物储存器电极的一部分组装，使得离子化药物将经皮递送，然后当离子治疗装置运行时被全身吸收。

公开(公告)号：US5042975A

公开(公告)日：1991-08-27

申请号：US046984

申请日：1987-05-07

申请人： Yie W. Chien ,  John Kong-Jiann Li ,  Jue-Chen Liu ,  Wei-Min Shi ,  Ovais Siddiqui ,  Ying Sun

发明人： Yie W. Chien ,  John Kong-Jiann Li ,  Jue-Chen Liu ,  Wei-Min Shi ,  Ovais Siddiqui ,  Ying Sun

IPC分类号： A61N1/30

CPC分类号： A61N1/0448 ,  A61N1/303 ,  A61N1/044

摘要： This invention relates to development of an iontotherapeutic device for regulated transdermal systemic administration of ionizable pharmaceutical compounds.It also provides an iontotherapeutic process for transdermal administration of ionized pharmaceuticals, particularly those which are otherwise transdermally absorbed to a small degree or not all, such as peptide pharmaceuticals, for example, insulins. The invention also relates to unit dose forms, for example, those in which an ionized pharmaceutical is dispersed in a hydrophilic polymer. The unit dose is adapted to be assembled as part of the pharmaceutical reservoir electrode, so that the ionized pharmaceutical will be delivered transdermally and then be absorbed systemically when the iontotherapeutic device is in operation.

摘要翻译： 本发明涉及用于可调节药物化合物的经调理的经皮系统给药的离子治疗装置的开发。 它还提供离子治疗方法，用于经皮给药离子化药物，特别是那些在很小程度上经皮吸收的药物，例如肽药物，例如胰岛素。 本发明还涉及单位剂量形式，例如其中离子化药物分散在亲水性聚合物中的那些形式。 单位剂量适于作为药物储存器电极的一部分组装，使得离子化药物将经皮递送，然后当离子治疗装置运行时被全身吸收。