公开(公告)号：US20130245021A1

公开(公告)日：2013-09-19

申请号：US13785271

申请日：2013-03-05

申请人： Yingzhi BI ,  Kenneth Gordon CARSON ,  Giovanni CIANCHETTA ,  Michael Alan GREEN ,  Godwin KUMI ,  Zhi LIANG ,  Ying Jade LIU ,  Alan MAIN ,  Yulian ZHANG ,  Gregory Glenn ZIPP

发明人： Yingzhi BI ,  Kenneth Gordon CARSON ,  Giovanni CIANCHETTA ,  Michael Alan GREEN ,  Godwin KUMI ,  Zhi LIANG ,  Ying Jade LIU ,  Alan MAIN ,  Yulian ZHANG ,  Gregory Glenn ZIPP

IPC分类号： C07D487/04

CPC分类号： C07D487/04 ,  A61K31/5025 ,  C07D241/04 ,  C07D401/14 ,  C07D403/14 ,  C07D498/18 ,  C07D519/00

摘要： Imidazo[1,2-b]pyridazine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.

公开(公告)号：US20130253194A1

公开(公告)日：2013-09-26

申请号：US13785355

申请日：2013-03-05

申请人： Yingzhi BI ,  Kenneth Gordon CARSON ,  Giovanni CIANCHETTA ,  Michael Alan GREEN ,  Godwin KUMI ,  Alan MAIN ,  Yulian ZHANG ,  Gregory Glenn ZIPP

发明人： Yingzhi BI ,  Kenneth Gordon CARSON ,  Giovanni CIANCHETTA ,  Michael Alan GREEN ,  Godwin KUMI ,  Alan MAIN ,  Yulian ZHANG ,  Gregory Glenn ZIPP

IPC分类号： C07D487/04

CPC分类号： C07D487/04 ,  A61K31/519 ,  C07B59/002 ,  C07B2200/05

摘要： Pyrazolo[1,5-a]pyrimidine-based compounds of the formula: are disclosed, wherein R1, R2 and R3 are defined herein. Compositions comprising the compounds and methods of their use to treat, manage and/or prevent diseases and disorders mediated by mediated by adaptor associated kinase 1 activity are also disclosed.