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    Methods and materials for identifying the origin of a carcinoma of unknown primary origin
    1.
    发明申请
    Methods and materials for identifying the origin of a carcinoma of unknown primary origin 审中-公开
    用于鉴定原发性原发癌的起源的方法和材料

    公开(公告)号：US20070065859A1

    公开(公告)日：2007-03-22

    申请号：US11523495

    申请日：2006-09-19

    申请人： Yixin Wang ,  Abhijit Mazumder ,  Dmitri Talantov ,  Timothy Jatkoe ,  Jonathan Baden

    发明人： Yixin Wang ,  Abhijit Mazumder ,  Dmitri Talantov ,  Timothy Jatkoe ,  Jonathan Baden

    IPC分类号： C12Q1/68 ,  G01N33/574 ,  G06F19/00 ,  C12M1/34

    CPC分类号： G01N33/57484 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/158 ,  G01N33/5091 ,  G16H10/40 ,  Y02A90/26

    摘要： The present invention provides a method of identifying origin of a metastasis of unknown origin by obtaining a sample containing metastatic cells; measuring Biomarkers associated with at least two different carcinomas; combining the data from the Biomarkers into an algorithm where the algorithm normalizes the Biomarkers against a reference; and imposes a cut-off which optimizes sensitivity and specificity of each Biomarker, weights the prevalence of the carcinomas and selects a tissue of origin determining origin based on highest probability determined by the algorithm or determining that the carcinoma is not derived from a particular set of carcinomas; and optionally measuring Biomarkers specific for one or more additional different carcinoma, and repeating the steps for additional Biomarkers.

    摘要翻译： 本发明提供了通过获得含有转移细胞的样品来鉴定未知来源的转移起点的方法; 测量与至少两种不同癌相关的生物标志物; 将来自生物标志物的数据组合成算法，其中算法使生物标志物反对参考标准化; 并强加了一个优化每个生物标志物的灵敏度和特异性的临界值，对癌症的患病率进行加权，并根据算法确定的最高概率选择确定起源的组织，或者确定癌不是从特定的一组 癌; 并且任选地测量对一种或多种另外的不同癌特异性的生物标志物，并重复其它生物标志物的步骤。