公开(公告)号：US06685320B2

公开(公告)日：2004-02-03

申请号：US10122223

申请日：2002-04-16

申请人： Yoko Hirohara ,  Toshifumi Mihashi ,  Koki Harumoto

发明人： Yoko Hirohara ,  Toshifumi Mihashi ,  Koki Harumoto

IPC分类号： A61B310

CPC分类号： A61B3/1015 ,  A61B3/107

摘要： A first signal and a second signal are captured at the same time, and the optical characteristics of a subject eye and the corneal shape thereof are measured simultaneously or substantially simultaneously. A calculation section captures a received light signal (first signal) from a first light receiving section and a received light signal (second signal) from a second light receiving section at the same timing or substantially the same timing, obtains the optical characteristics of the subject eye on the basis of the first signal, and obtains the corneal shape of the subject eye on the basis of the second signal. A measurement timing decision section decides, on the basis of the first and/or the second signal, measurement timings of the first signal and the second signal as objects for which a measurement calculation is carried out. The measurement timing decision section uses, as a predetermined decision factor for measuring timing, at least one of a blink, a poor tear film, a lack of a pupil diameter, and a poor eyelid. A display section displays, as an image, the first signal and/or the second signal. The operator judges, on the basis of the displayed first signal and/or second signal, suitableness of measurement with the predetermined decision factor for measuring timing, and decides a measurement signal used for the calculation section.

摘要翻译： 同时捕获第一信号和第二信号，同时或基本上同时测量被检眼的光学特性及其角膜形状。 计算部分以相同的定时或基本相同的定时从第一光接收部分接收来自第二光接收部分的接收光信号（第一信号）和来自第二光接收部分的接收光信号（第二信号），获得对象的光学特性 基于第一信号，基于第二信号获得被检眼的角膜形状。 测量定时决定部基于第一信号和/或第二信号，决定作为进行测量计算的对象的第一信号和第二信号的测量定时。 测量定时决定部使用眨眼，不良泪液，瞳孔直径不足，眼睑不良中的至少一个作为测定定时的预定决定因素。 显示部分显示第一信号和/或第二信号作为图像。 操作者根据所显示的第一信号和/或第二信号，根据用于测量定时的预定决定因素来判断测量的适当性，并且确定用于计算部分的测量信号。

公开(公告)号：US07677731B2

公开(公告)日：2010-03-16

申请号：US11940886

申请日：2007-11-15

申请人： Toshifumi Mihashi ,  Yoko Hirohara ,  Takashi Fujikado ,  Naoyuki Maeda

发明人： Toshifumi Mihashi ,  Yoko Hirohara ,  Takashi Fujikado ,  Naoyuki Maeda

IPC分类号： A61B3/10 ,  A61B3/00

CPC分类号： A61B3/1015 ,  A61B3/10

摘要： Scattering can be measured by using an optical system having a Hartman-Shack wave-surface sensor. An eye optical characteristic measuring instrument comprises a light source unit 10 for emitting a light beam of a wavelength in the near-infrared region, an illumination optical system 40 for illuminating a small area of the retinal of an eye to be measured with the light beam from the light source unit 10, a light-receiving optical system 20 for receiving a part of the reflected beam of the light beam from the light source unit 10 reflected from the retina through a converting member for converting the part of the reflected light beam into at least substantially 17 light beams, a light-receiving section 23 for receiving the received light beam directed by the light-receiving optical system 20 and generating a signal, and a calculating unit for determining the wavefront aberration of the light beam entering the light-receiving optical system 20 and the degree of scattering of the received light beam on the basis of the signal from the light-receiving section 23.

摘要翻译： 可以通过使用具有Hartman-Shack波表面传感器的光学系统来测量散射。 眼睛光学特性测量仪器包括用于发射近红外区域的波长的光束的光源单元10，用于用光束照射待测眼睛的视网膜的小区域的照明光学系统40 来自光源单元10的光接收光学系统20，用于接收来自光源单元10的光束的反射光束的一部分，该光源单元10从视网膜反射通过转换部件，用于将部分反射光束转换成 至少基本上17个光束，用于接收由光接收光学系统20引导的接收光束并产生信号的光接收部分23，以及用于确定进入发光装置的光束的波前像差的计算单元， 基于来自光接收部23的信号，接收光学系统20和接收光束的散射程度。

公开(公告)号：US07677728B2

公开(公告)日：2010-03-16

申请号：US11723624

申请日：2007-03-21

申请人： Yoko Hirohara ,  Toshifumi Mihashi

发明人： Yoko Hirohara ,  Toshifumi Mihashi

IPC分类号： A61B3/14

CPC分类号： A61B3/101

摘要： A subject is placed in a more natural state or is encouraged to blink at specified intervals to obtain a measurement result under a fixed condition, and the judgment of the degree of dry eye is facilitated. A measurement part obtains, based on a reflected light flux from a subject eye, optical characteristic data of a two-dimensional vector form representing the time course of each optical characteristic of the subject eye in an blink interval from a certain blink to a next blink with respect to the first to the nth blink intervals. An analysis part one-dimensionally arranges each of the optical characteristic data with respect to the first to the nth blink intervals measured by the measurement part, and arranges the one-dimensional arrangement of the optical characteristic in a p-th blink interval at a p column to create a two-dimensional array, and performs a principal component analysis processing on the two-dimensional array.

摘要翻译： 受试者处于更自然的状态，或鼓励以规定的间隔眨眼以在固定条件下获得测量结果，并且便于对干眼度的判断。 测量部件基于来自被检眼的反射光通量，从在特定的闪烁到下一次闪烁的眨眼间隔中获得表示被检眼的每个光学特性的时间过程的二维矢量形状的光学特性数据 相对于第一到第n个闪烁间隔。 分析部分对由测量部分测量的第一至第N闪烁间隔的每个光学特性数据进行一维排列，并将光学特性的一维布置在第p个闪烁间隔中排列在ap列 创建二维阵列，并对二维​​阵列进行主成分分析处理。

公开(公告)号：US20070153667A1

公开(公告)日：2007-07-05

申请号：US11607855

申请日：2006-12-04

申请人： Toshifumi Mihashi ,  Yoko Hirohara

发明人： Toshifumi Mihashi ,  Yoko Hirohara

IPC分类号： G11B7/00

CPC分类号： A61B3/032

摘要： A visual target presenting optical system has a light source that illuminates a visual target to be viewed by a subject, and a visual target presentation state changing unit that can change the direction in which the visual target will be presented to the subject. An alignment luminous flux casting unit casts an alignment luminous flux toward a subject eye at timing prior to the presentation of the visual target. An alignment light receiving optical system and a light receiving unit receive a reflected luminous flux from the subject eye reflecting the luminous flux. A change control unit instructs the visual target presentation state changing unit to change the visual target presenting direction on the basis of the light receiving position of the reflected luminous fluxes received by the light receiving unit.

摘要翻译： 视觉目标呈现光学系统具有照亮被摄体观看的视觉目标的光源，以及可以改变目标被呈现给对象的方向的视觉目标呈现状态改变单元。 对准光通量投射单元在呈现视觉目标之前的定时向对象眼投射对准光束。 对准光接收光学系统和光接收单元接收来自反射光束的来自被摄体的反射光束。 改变控制单元指示视觉目标呈现状态改变单元基于由光接收单元接收的反射光束的光接收位置来改变视觉目标呈现方向。

公开(公告)号：US06905209B2

公开(公告)日：2005-06-14

申请号：US10399612

申请日：2001-10-16

申请人： Toshifumi Mihashi ,  Yoko Hirohara ,  Naoyuki Maeda

发明人： Toshifumi Mihashi ,  Yoko Hirohara ,  Naoyuki Maeda

IPC分类号： A61B3/10 ,  A61B3/103 ,  A61B3/107

CPC分类号： A61B3/1015 ,  A61B3/10 ,  A61B3/107

摘要： Measurement data (measured results) obtained under a plurality of conditions and image data and/or numerical data corresponding to the measured results are displayed collectively or selectively. An optical characteristics measuring device (100) measures/displays, for example, the optical characteristics of an eye to be measured (60) as an object. A first lighting optical system (10) includes a first light source (11) for applying an optical flux of a specified pattern to the eye to be measured (60). A first light receiving optical system (20) includes a first light receiving unit (23) for receiving light reflected from the eye (60). A light transmitting/receiving optical system (30) mainly conducts an alignment adjustment, and includes a second light receiving unit (35) for receiving light reflected from the eye (60). A common optical system (40) is disposed on the optical axis of a light flux emitted from the first lighting optical system (10), and is commonly included in the first lighting.

摘要翻译： 在多个条件下获得的测量数据（测量结果）和对应于测量结果的图像数据和/或数值数据被集体地或选择性地显示。 光学特性测量装置（100）测量/显示例如作为对象的待测眼（60）的光学特性。 第一照明光学系统（10）包括用于将特定图案的光通量施加到被测量眼（60）的第一光源（11）。 第一光接收光学系统（20）包括用于接收从眼睛（60）反射的光的第一光接收单元（23）。 光发射/接收光学系统（30）主要进行对准调整，并且包括用于接收从眼睛（60）反射的光的第二光接收单元（35）。 普通光学系统（40）设置在从第一照明光学系统（10）发射的光束的光轴上，并且通常包括在第一照明中。

公开(公告)号：US07568800B2

公开(公告)日：2009-08-04

申请号：US11812079

申请日：2007-06-14

申请人： Toshifumi Mihashi ,  Yoko Hirohara

发明人： Toshifumi Mihashi ,  Yoko Hirohara

IPC分类号： A61B3/14

CPC分类号： A61B3/10 ,  A61B3/0025 ,  G06T7/33 ,  G06T2207/30041

摘要： To provide a spectroscopic fundus measuring apparatus capable of identifying each part in spectral fundus images easily and accurately based on its spectral characteristic and a measuring method therefor. A spectral fundus image measuring apparatus 1 of the present invention includes: an illumination optical system 10; a light receiving optical system 20 for photographing a series of spectral fundus images of different wavelengths; an image processing section 7 for processing the spectral fundus images; a storage section 7A; and a display section 7B. The image processing section 7 has a position correcting section 72 for correcting the series of spectral fundus images to match the positions of the same parts therein, and an image analyzing section 73 for calculating the spectral characteristic of each part in the spectral fundus images based on the series of spectral fundus images corrected in the position correcting section 72. The storage section 7A stores the spectral characteristics of the parts together with standard spectral characteristics of specific parts. The image processing section 7 has a first grouping section 74A for comparing the spectral characteristic of each part with the standard spectral characteristics of the specific parts to divide the parts into groups corresponding to the specific parts.

摘要翻译： 提供一种能够基于其光谱特性容易且准确地识别光谱眼底图像中的每个部分的光谱眼底测量装置及其测量方法。 本发明的光谱眼底图像测量装置1包括：照明光学系统10; 用于拍摄不同波长的一系列光谱眼底图像的光接收光学系统20; 用于处理光谱眼底图像的图像处理部分7; 存储部7A; 和显示部分7B。 图像处理部分7具有位置校正部分72，用于校正一系列光谱眼底图像以匹配其中相同部分的位置;以及图像分析部分73，用于计算基于光谱眼底图像中的每个部分的光谱特性 在位置校正部分72中校正的一系列光谱眼底图像。存储部分7A将各部分的光谱特性与特定部分的标准光谱特性一起存储。 图像处理部分7具有第一分组部分74A，用于将各部分的光谱特性与特定部分的标准光谱特性进行比较，以将部分划分成与特定部分相对应的组。

公开(公告)号：US07441900B2

公开(公告)日：2008-10-28

申请号：US10467159

申请日：2002-02-07

申请人： Toshifumi Mihashi ,  Yoko Hirohara

发明人： Toshifumi Mihashi ,  Yoko Hirohara

IPC分类号： A61B3/02

CPC分类号： A61B3/022 ,  A61B3/032 ,  A61B3/112

摘要： A contrast chart device of the present invention comprises a contrast target presenting part for presenting a contrast target for a contrast sensitivity test at prescribed timing; a pupil data measuring part for producing an image of an anterior ocular segment of a subject and measuring the diameter or area of a pupil region in the anterior ocular segment; and a measurement timing forming part for forming timing at which the pupil data measuring part performs measurement.

摘要翻译： 本发明的对比图装置包括对比度目标呈现部分，用于在规定的时刻呈现对比度敏感度测试的对比度目标; 瞳孔数据测量部分，用于产生对象的前眼部分的图像，并测量前眼部的瞳孔区域的直径或面积; 以及用于形成瞳孔数据测量部进行测量的定时的测量定时形成部。

公开(公告)号：US20080007691A1

公开(公告)日：2008-01-10

申请号：US11812079

申请日：2007-06-14

申请人： Toshifumi Mihashi ,  Yoko Hirohara

发明人： Toshifumi Mihashi ,  Yoko Hirohara

IPC分类号： A61B3/14

CPC分类号： A61B3/10 ,  A61B3/0025 ,  G06T7/33 ,  G06T2207/30041

摘要： To provide a spectroscopic fundus measuring apparatus capable of identifying each part in spectral fundus images easily and accurately based on its spectral characteristic and a measuring method therefor. A spectral fundus image measuring apparatus 1 of the present invention includes: an illumination optical system 10; a light receiving optical system 20 for photographing a series of spectral fundus images of different wavelengths; an image processing section 7 for processing the spectral fundus images; a storage section 7A; and a display section 7B. The image processing section 7 has a position correcting section 72 for correcting the series of spectral fundus images to match the positions of the same parts therein, and an image analyzing section 73 for calculating the spectral characteristic of each part in the spectral fundus images based on the series of spectral fundus images corrected in the position correcting section 72. The storage section 7A stores the spectral characteristics of the parts together with standard spectral characteristics of specific parts. The image processing section 7 has a first grouping section 74A for comparing the spectral characteristic of each part with the standard spectral characteristics of the specific parts to divide the parts into groups corresponding to the specific parts.

摘要翻译： 提供一种能够基于其光谱特性容易且准确地识别光谱眼底图像中的每个部分的光谱眼底测量装置及其测量方法。 本发明的光谱眼底图像测量装置1包括：照明光学系统10; 用于拍摄不同波长的一系列光谱眼底图像的光接收光学系统20; 用于处理光谱眼底图像的图像处理部分7; 存储部分7A; 以及显示部分7 B.图像处理部分7具有位置校正部分72，用于校正一系列光谱眼底图像以匹配其中相同部分的位置;以及图像分析部分73，用于计算各部分的光谱特性 在基于在位置校正部分72中校正的一系列光谱眼底图像的光谱眼底图像中。存储部分7A将这些部分的光谱特性与特定部分的标准光谱特性一起存储。 图像处理部分7具有第一分组部分74A，用于将各部分的光谱特性与特定部分的标准光谱特征进行比较，以将部分划分成与特定部分相对应的组。

公开(公告)号：US20070229760A1

公开(公告)日：2007-10-04

申请号：US11723624

申请日：2007-03-21

申请人： Yoko Hirohara ,  Toshifumi Mihashi

发明人： Yoko Hirohara ,  Toshifumi Mihashi

IPC分类号： A61B3/14

CPC分类号： A61B3/101

摘要： A subject is placed in a more natural state or is encouraged to blink at specified intervals to obtain a measurement result under a fixed condition, and the judgment of the degree of dry eye is facilitated. A measurement part obtains, based on a reflected light flux from a subject eye, optical characteristic data of a two-dimensional vector form representing the time course of each optical characteristic of the subject eye in an blink interval from a certain blink to a next blink with respect to the first to the nth blink intervals. An analysis part one-dimensionally arranges each of the optical characteristic data with respect to the first to the nth blink intervals measured by the measurement part, and arranges the one-dimensional arrangement of the optical characteristic in a p-th blink interval at a p column to create a two-dimensional array, and performs a principal component analysis processing on the two-dimensional array.

摘要翻译： 受试者处于更自然的状态，或鼓励以规定的间隔眨眼以在固定条件下获得测量结果，并且便于对干眼度的判断。 测量部件基于来自被检眼的反射光通量，从在特定的闪烁到下一次闪烁的眨眼间隔中获得表示被检眼的每个光学特性的时间过程的二维矢量形状的光学特性数据 相对于第一到第n个闪烁间隔。 分析部分对由测量部分测量的第一至第N闪烁间隔的每个光学特性数据进行一维排列，并将光学特性的一维布置在第p个闪烁间隔中排列在ap列 创建二维阵列，并对二维​​阵列进行主成分分析处理。

公开(公告)号：US07241012B2

公开(公告)日：2007-07-10

申请号：US10758285

申请日：2004-01-16

申请人： Toshifumi Mihashi ,  Yoko Hirohara ,  Teruhito Kuroda ,  Naoyuki Maeda ,  Takashi Fujikado

发明人： Toshifumi Mihashi ,  Yoko Hirohara ,  Teruhito Kuroda ,  Naoyuki Maeda ,  Takashi Fujikado

IPC分类号： A61B3/10 ,  A61B3/00

CPC分类号： A61B3/101

摘要： There is provided an ophthalmologic apparatus which can be effectively used for the clinic of a dry eye by using, as a basic principle, that when a tear film dries up, a corneal shape is changed and/or a wavefront aberration becomes large. When a measurement is started, the ophthalmologic apparatus is aligned. An arithmetic part performs an initial setting of a measurement interval of the apparatus, a measurement time and the like by a wavefront measurement part. An input part or the arithmetic part triggers a measurement start, and the arithmetic part repeats a measurement of the corneal shape and corneal wavefront aberrations by a measurement part until time reaches a measurement end time. When the time reaches the measurement end time, a judgment part analyzes a breakup state as one index for judgment of a state of a dry eye. The judgment part obtains values relating to the breakup to output them, and performs an automatic diagnosis about dry eye on the basis of the values.

摘要翻译： 作为基本原理，提供了一种可以有效地用于干眼症的眼科装置，当泪膜干燥时，改变角膜形状和/或波前像差变大。 当测量开始时，眼科装置对准。 算术部通过波阵面测量部进行装置的测定间隔，测定时间等的初始设定。 输入部分或算术部分触发测量开始，并且运算部分重复通过测量部分的角膜形状和角膜波前像差的测量，直到时间到达测量结束时间。 当时间到达测量结束时间时，判断部件将分解状态分析为用于判断干眼状态的一个指标。 判断部分获得与分解相关的值以输出它们，并且基于该值来执行关于干眼症的自动诊断。