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1.发明授权Chroman carboxylic acid derivatives for the treatment of diabetes and lipid disorders 失效用于治疗糖尿病和脂质疾病的色甘酸羧酸衍生物公开(公告)号：US07446127B2
公开(公告)日：2008-11-04
申请号：US10926615
申请日：2004-08-26
IPC分类号： A01N43/16 , C07D263/30
CPC分类号： C07D413/12 , C07D413/14
摘要： There are disclosed derivatives of 3-chromancarboxylic acid represented by formula I their pharmaceutically acceptable salts thereof and prodrugs thereof which are useful for treatment and control of non-insulin dependent diabetes mellitus (type II diabetes) and its related vascular disease as well as obesity and lipid disorders.
摘要翻译： 公开了由式I表示的3-苯并二氢吡喃衍生物，其可药用盐和其前药可用于治疗和控制非胰岛素依赖性糖尿病（II型糖尿病）及其相关血管疾病以及肥胖症和 脂质紊乱。
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2.发明授权Substituted carboxylic acid derivatives for the treatment of diabetes and lipid disorders, their preparation and use 失效用于治疗糖尿病和脂质疾病的取代的羧酸衍生物，其制备和用途公开(公告)号：US07456293B2
公开(公告)日：2008-11-25
申请号：US11391031
申请日：2006-03-28
IPC分类号： A61K31/4184 , C07D235/04
CPC分类号： C07D235/10
摘要： The present invention is concerned with racemic or enantiomerically enriched substituted carboxylic acids and derivatives thereof represented by Formula 1; or pharmaceutically acceptable salts thereof. The present invention also includes pharmaceutical compositions comprising an effective amount of a compound of Formula 1 in admixture with a pharmaceutically acceptable carrier or excipient. The compositions may include additional therapeutic agents for combination therapy. The present invention provides a new class of pharmaceutically active compounds, which are useful in the treatment and control of diabetes and its related metabolic diseases.
摘要翻译： 本发明涉及由式1表示的外消旋或对映体富集的取代羧酸及其衍生物; 或其药学上可接受的盐。 本发明还包括药物组合物，其包含与药学上可接受的载体或赋形剂混合的有效量的式1化合物。 组合物可以包括用于组合治疗的其它治疗剂。 本发明提供了一类新的药物活性化合物，其可用于治疗和控制糖尿病及其相关代谢疾病。
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3.发明申请Substituted carboxylic acid derivatives for the treatment of diabetes and lipid disorders, their preparation and use 失效用于治疗糖尿病和脂质疾病的取代的羧酸衍生物，其制备和用途公开(公告)号：US20060281802A1
公开(公告)日：2006-12-14
申请号：US11391031
申请日：2006-03-28
申请人： Yong Choi , Hunwoo Shin , Palanichamy Ilankumaran
发明人： Yong Choi , Hunwoo Shin , Palanichamy Ilankumaran
IPC分类号： A61K31/4184 , C07D235/12
CPC分类号： C07D235/10
摘要： The present invention is concerned with racemic or enantiomerically enriched substituted carboxylic acids and derivatives thereof represented by Formula 1; or pharmaceutically acceptable salts thereof. The present invention also includes pharmaceutical compositions comprising an effective amount of a compound of Formula 1 in admixture with a pharmaceutically acceptable carrier or excipient. The compositions may include additional therapeutic agents for combination therapy. The present invention provides a new class of pharmaceutically active compounds, which are useful in the treatment and control of diabetes and its related metabolic diseases.
摘要翻译： 本发明涉及由式1表示的外消旋或对映体富集的取代羧酸及其衍生物; 或其药学上可接受的盐。 本发明还包括药物组合物，其包含与药学上可接受的载体或赋形剂混合的有效量的式1化合物。 组合物可以包括用于组合治疗的其它治疗剂。 本发明提供了一类新的药物活性化合物，其可用于治疗和控制糖尿病及其相关代谢疾病。
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4.发明申请Chroman carboxylic acid derivatives for the treatment of diabetes and lipid disorders 失效用于治疗糖尿病和脂质疾病的色甘酸羧酸衍生物公开(公告)号：US20050107371A1
公开(公告)日：2005-05-19
申请号：US10926615
申请日：2004-08-26
申请人： Yong Choi , Hunwoo Shin , Palanichamy Ilankumaran , Hong Kim
发明人： Yong Choi , Hunwoo Shin , Palanichamy Ilankumaran , Hong Kim
IPC分类号： A61K31/422 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , C07D413/12 , C07D413/14 , C07D417/14
CPC分类号： C07D413/12 , C07D413/14
摘要： There are disclosed derivatives of 3-chromancarboxylic acid represented by formula I their pharmaceutically acceptable salts thereof and prodrugs thereof which are useful for treatment and control of non-insulin dependent diabetes mellitus (type II diabetes) and its related vascular disease as well as obesity and lipid disorders
摘要翻译： 公开了由式I表示的3-苯并二氢吡喃衍生物，其可药用盐和其前药可用于治疗和控制非胰岛素依赖性糖尿病（II型糖尿病）及其相关血管疾病以及肥胖症和 脂质紊乱
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