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公开(公告)号：US4500561A
公开(公告)日：1985-02-19
申请号：US516997
申请日：1983-07-25
CPC分类号： C23C2/265
摘要： The molten exterior surface portion of a hot dip galvanized steel strip is solidified after the strip is withdrawn from a bath of molten zinc by spraying finely divided particles of a liquid nucleating agent for initiating solidification. The particles are sprayed into an electrostatic field alongside the strip. The particles are initially directed along a path which avoids impingement against the strip. However, the smaller particles are attracted to the strip under the influence of the electrostatic field, to initiate solidification. The larger particles have a momentum along their path large enough to resist the influence of the electrostatic field, thereby permitting the larger particles to continue along a path which avoids impingement. This minimizes the formation of undesirably large spangles and an undesirable surface appearance on the strip.
摘要翻译： 通过喷射细碎的液体成核剂颗粒从熔融锌浴中取出钢带后，将热浸镀锌钢带的熔融外表面部分固化，以引发固化。 颗粒沿着条带被喷射到静电场中。 颗粒最初被引导沿着避免撞击条带的路径。 然而，较小的颗粒在静电场的影响下被吸引到条带上，以引发凝固。 较大的颗粒沿其路径具有足够大的动量以抵抗静电场的影响，从而允许较大的颗粒沿着避免冲击的路径继续。 这使得在条带上形成不期望的大花纹和不期望的表面外观最小化。
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公开(公告)号：US08774883B2
公开(公告)日：2014-07-08
申请号：US13310181
申请日：2011-12-02
IPC分类号： H01P1/203
CPC分类号： H01B12/02 , H01B12/16 , H02G15/34 , H02J3/36 , H02J2003/365 , Y02E40/648 , Y02E60/60
摘要： A DC superconducting coaxial transmission system provides electrical transmission of 5,000 megawatts of energy while simultaneously delivering liquid hydrogen. The transmission system includes a coaxial transmission segment including an inner superconductor, an outer superconductor disposed in surrounding relation to the inner conductor, and a dielectric insulator disposed between the inner superconductor and the outer superconductor. Liquid hydrogen surrounds the superconductors. Three phase transformers and poly phase rectifier/inverters provide a DC voltage source to the superconductors from the electrical grid. In one embodiment, a switching circuit connected between the voltage source and the superconductor injects a cancellation current component into the direct current flow. The cancellation current component is polarized to flow in a direction opposite to the direct current flow to produce a current zero, thus enabling safe interruption of the high DC current while minimizing the magnitude of transient voltages during switching.
摘要翻译： DC超导同轴传输系统提供5,000兆瓦能量的电传输，同时输送液态氢。 传动系统包括一个同轴传动段，它包括一个内部超导体，一个围绕内部导体设置的外部超导体，以及一个布置在内部超导体和外部超导体之间的绝缘绝缘体。 液态氢围绕超导体。 三相变压器和多相整流/逆变器为电网的超导体提供直流电压源。 在一个实施例中，连接在电压源和超导体之间的开关电路将消除电流分量注入到直流电流中。 消除电流分量被极化以在与直流电流相反的方向上流动以产生电流零，从而使得能够在最小化切换期间的瞬态电压的幅度的情况下安全地中断高直流电流。
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公开(公告)号：US08075878B2
公开(公告)日：2011-12-13
申请号：US11812361
申请日：2007-06-18
申请人： William A. Carter , David Strayer
发明人： William A. Carter , David Strayer
CPC分类号： A61K38/212
摘要： An antiviral/immunomodulatory response in an animal is induced by oral administration to an infected animal, including humans, of a human α-interferon. Methods of conferring resistance or mitigating the effects of exposure to a virus including avian influenza are described.
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4.发明申请GENETEC REGULATION OF HOST DEFENSE MECHANISMS BY MUCOSAL EXPOSURE TO NATURAL INTERFERON ALPHA SPECIES 审中-公开通过自然暴露于自然干扰物种的遗传机制对遗传机制的监测公开(公告)号：US20110044946A1
公开(公告)日：2011-02-24
申请号：US12735753
申请日：2009-02-17
申请人： William A. Carter , David Strayer
发明人： William A. Carter , David Strayer
CPC分类号： A61K38/212 , A61K9/0014
摘要： A mixture of α-interferons (IFN-α) is used in vitro or in vivo as an antimicrobial agent or anticancer agent. It may be administered by topical application to oral or nasal, and/or buccal mucosa to combat the effects of infection by bacteria or protozoa, cancer, or other pathogenic disease process (e.g., autoimmune or neurodegenerative disease).
摘要翻译： α-干扰素（IFN-α）的混合物在体外或体内用作抗微生物剂或抗癌剂。 它可以通过局部施用给口服或鼻腔和/或颊粘膜来对抗细菌或原生动物，癌症或其它致病性疾病过程（例如自身免疫性或神经变性疾病）感染的作用。
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公开(公告)号：US20090304630A1
公开(公告)日：2009-12-10
申请号：US11882532
申请日：2007-08-02
申请人： William A. Carter , David Strayer
发明人： William A. Carter , David Strayer
IPC分类号： A61K38/21 , A61K31/7052 , A61P11/00
CPC分类号： A61K31/4196 , A61K31/24 , A61K31/7088 , A61K38/005 , A61K38/212 , A61K48/00 , A61K2300/00 , C12N15/111 , C12N15/117 , C12N2310/17 , C12N2320/31
摘要： Severe acute respiratory syndrome is treated with a natural human alpha interferon, a dsRNA or both natural human alpha interferon and a dsRNA. Avian influenza is treated with natural human alpha interferon, neuraminidase inhibitor(s) and ribavirin. Effects of influenza virus are mitigated with a dsRNA in combination with a neuraminidase influenza virus inhibitor. These two products, dsRNA, and alpha interferon, have therapeutic utility either given preventively (prophylactically) or in treatment of active disease. These unique immunological/antiviral actions, operating through immunological “cascades” ameliorates the lethal effects of viral mutation which, by causing resistance to commonly available drugs, greatly accelerates the death rate. For example, in 1918-1920, Avian Influenza caused the death of approximately 40 million people worldwide (ref. National Geographic, September, 2005).
摘要翻译： 用天然人α干扰素，dsRNA或天然人α干扰素和dsRNA治疗严重急性呼吸综合征。 用天然人α干扰素，神经氨酸酶抑制剂和利巴韦林治疗禽流感。 使用dsRNA与神经氨酸酶流感病毒抑制剂组合，可以缓解流感病毒的影响。 这两种产品，dsRNA和α干扰素具有预防性（预防性）或治疗活动性疾病的治疗效用。 通过免疫学“级联”操作的这些独特的免疫/抗病毒作用改善了病毒突变的致死作用，通过引起对常用药物的抗性，极大地加速了死亡率。 例如，在1918年至1920年间，禽流感导致全世界约4000万人死亡（参考国家地理杂志，2005年9月）。
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公开(公告)号：US6159293A
公开(公告)日：2000-12-12
申请号：US46307
申请日：1998-03-23
申请人： Anatoly Kolesnichenko , Volodimir Vodyanyuk , James J. Deegan , William A. Carter , Philip G. Martin
发明人： Anatoly Kolesnichenko , Volodimir Vodyanyuk , James J. Deegan , William A. Carter , Philip G. Martin
摘要： A hot dip coating system comprises a bath of molten coating metal contained in a vessel having a strip passage opening located below the top surface of the bath. A metal strip is directed along a path extending through the strip passage opening and through the bath of molten coating metal, to coat the strip. An electromagnet is employed to prevent the escape of the bulk of the molten coating metal from the bath through the strip passage opening while permitting the strip to move along its path. Expedients are provided to reduce leakage of molten coating metal through the strip passage opening.
摘要翻译： 热浸涂层系统包括容纳在容器中的熔融涂覆金属浴，其具有位于浴的顶表面下方的带通道开口。 金属带沿着延伸通过条形通道开口并通过熔融涂覆金属的浴的路径被引导以涂覆条带。 使用电磁体来防止熔融涂覆金属的大部分通过条形通道开口从熔池中逸出，同时允许条带沿其路径移动。 提供了提高熔融涂层金属通过带状通道开口的泄漏的方法。
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7.发明授权
公开(公告)号：US6130206A
公开(公告)日：2000-10-10
申请号：US376457
申请日：1995-01-23
申请人： William A. Carter
发明人： William A. Carter
CPC分类号： A61K31/713
摘要： Virus infections promoting Chronic Fatigue can be diagnosed by assessing the 2'-5'A/RNase L pathway, including measurement of 2'-5'A oligonucleotide levels in the patient's circulating peripheral leucocytes, and comparing these resuls with those of healthy individuals. Double-stranded RNAs, notably mismatched dsRNAs, when administered in appropriate amounts, increase the 2'-5'A and normalize the antiviral pathway in patients with Chronic Fatigue Syndrome and improve the clinical symptoms.
摘要翻译： 可以通过评估2'-5'A / RNase L途径来诊断促进慢性疲劳的病毒感染，包括测量患者循环外周白细胞中的2'-5'A寡核苷酸水平，并将这些患者与健康个体进行比较。 当以适当的量施用时，双链RNAs，特别是错配的dsRNAs增加了2'-5'A并使慢性疲劳综合征患者的抗病毒途径正常化并改善了临床症状。
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公开(公告)号：US5827576A
公开(公告)日：1998-10-27
申请号：US822782
申请日：1997-03-21
CPC分类号： C23C2/24
摘要： A hot dip coating apparatus and method for coating a continuous steel strip, wire, or like continuous member with zinc, aluminum, tin, lead, or alloys of each. A molten coating bath is contained in a vessel having a bottom opening upwardly through which the steel member is directed. Magnetic containment devices located below the vessel's bottom opening prevent the escape of molten metal from the vessel through the opening. There are no guide rolls, or other rolls that act on the continuous steel member, in the bath.
摘要翻译： 一种用于将锌，铝，锡，铅或其合金涂覆在连续钢带，钢丝等连续部件上的热浸涂装置和方法。 在具有向上的底部开口的容器中容纳熔融涂层浴，钢构件穿过该底部开口。 位于容器底部开口下方的磁性容纳装置防止熔融金属从容器中通过开口逸出。 在浴中没有作用于连续钢构件的导向辊或其它辊。
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公开(公告)号：US4950652A
公开(公告)日：1990-08-21
申请号：US125097
申请日：1987-11-25
申请人： William A. Carter
发明人： William A. Carter
IPC分类号： A61K38/00 , A61K31/435 , A61K31/70 , A61K31/713 , A61K31/785 , A61K38/19 , A61K38/21 , A61K38/55 , A61P31/12 , A61P31/18 , A61P43/00 , C07H21/02
CPC分类号： A61K31/70 , A61K38/21 , Y10S514/934
摘要： Studies of Synergistic combinations of dsRNAs and anti-viral agents in the treatment of viral diseases indicates dsRNA, especially mismatched dsRNA, plays a powerful and versatile role as a core drug in combination therapy for human viral pathogens, notably for ARC and AIDS.
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10.发明授权Double-stranded ribonucleic acids with rugged physico-chemical structure and highly specific biologic activity 有权具有坚固的物理化学结构和高度特异性生物活性的双链核糖核酸公开(公告)号：US08722874B2
公开(公告)日：2014-05-13
申请号：US13077742
申请日：2011-03-31
CPC分类号： C12N15/1138 , A61K31/7105 , A61K31/713 , A61K39/00 , A61K39/39 , A61K2039/55561 , C12N15/111 , C12N15/117 , C12N2310/14 , C12N2310/17 , C12N2310/50 , C12N2320/31 , C12N2320/51 , C12N2320/52
摘要： A novel form of Rugged dsRNA with a unique composition and physical characteristics was identified with high specificity of binding to TLR3, which conveys an important range of therapeutic opportunities. Unlike the previous known antiviral Ampligen® (poly I, poly C12,U) the new and improved form (poly I, poly C30,U) has a reduced tendency to form branched dsRNA which results in increased bioactivity due to an increased ability to bind TLR3 receptor. Pharmaceutical formulations containing the new nucleic acid as active ingredients and methods of treatment are also provided. The invention also provides a description of the physicochemical properties of this novel form of Rugged dsRNA and a method for its preparation in substantially pure form. DsRNAs acting thru TLR3 receptor activation are potent antiviral compounds as well as anticancer agents; also through secondary immunomodulation they can enhance the bioactivity of vaccines and also treat autoimmune disorders.
摘要翻译： 鉴定了具有独特组成和物理特性的Rugged dsRNA的新型形式，具有高TLR3结合特异性，其传递了重要的治疗机会。 与以前已知的抗病毒Ampligen®（poly I，poly C12，U）不同，新的和改进的形式（poly I，poly C30，U）具有降低的形成支链dsRNA的趋势，其由于增加的结合能力而导致增加的生物活性 TLR3受体。 还提供了含有新核酸作为活性成分和治疗方法的药物制剂。 本发明还提供了这种新型形式的Rugged dsRNA的物理化学性质的描述及其以基本上纯的形式制备的方法。 通过TLR3受体激活作用的DsRNA是有效的抗病毒化合物以及抗癌剂; 也通过二次免疫调节，它们可以增强疫苗的生物活性，也可以治疗自身免疫性疾病。
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