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公开(公告)号：US20130295062A1
公开(公告)日：2013-11-07
申请号：US13979610
申请日：2012-01-18
IPC分类号： A61K38/48
CPC分类号： A61K38/4813 , A61K35/15 , A61K35/30 , C12N5/10
摘要： The present invention relates to methods and compositions for use in the treatment of neurological disorders, such as Alzheimer's disease and dementia. In one embodiment, the present invention provides a method of treatment of Alzheimer's disease in an individual by administering a composition overexpressing ACE to the individual. In another embodiment, the method of treatment comprises administering a composition comprising a therapeutically effective dosage of ACE.
摘要翻译： 本发明涉及用于治疗诸如阿尔茨海默病和痴呆的神经障碍的方法和组合物。 在一个实施方案中，本发明提供了通过向个体施用过表达ACE的组合物来治疗个体中阿尔茨海默病的方法。 在另一个实施方案中，治疗方法包括施用包含治疗有效剂量的ACE的组合物。
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公开(公告)号：US20110104175A1
公开(公告)日：2011-05-05
申请号：US12995401
申请日：2009-06-03
IPC分类号： A61K39/395 , A61K38/07 , A61P11/00
CPC分类号： C07K14/8103 , A61K38/556
摘要： The invention relates to compositions and methods for treating fibrosing lung diseases, reducing pulmonary cytokine production in animals, treating bleomycin induced lung disease and treating cancer. Specifically, the present subject matter incorporates inactivation of the N-terminal site of an angiotensin-converting enzyme and/or administration of AcSDKP.
摘要翻译： 本发明涉及用于治疗纤维化肺疾病，减少动物中的肺细胞因子产生，治疗博来霉素诱导的肺部疾病和治疗癌症的组合物和方法。 具体地，本主题包括血管紧张素转换酶的N-末端部位的灭活和/或AcSDKP的施用。
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公开(公告)号：US20080295192A1
公开(公告)日：2008-11-27
申请号：US11759574
申请日：2007-06-07
IPC分类号： A01K67/027 , C07H21/04 , C12N15/63
CPC分类号： C12N15/63 , A01K2217/075 , A61K48/00 , C12N15/67
摘要： The present invention is directed to a method for deleting DNA sequences in a tissue specific manner. In one embodiment, DNA sequences are specifically deleted in germline tissue. In a second embodiment, DNA sequences are specifically deleted in desired somatic tissue. The present invention is further directed to a nucleic acid molecule for use in the method. More specifically, a nucleic acid molecule is provide by the present invention which comprises (a) a recombinase site, (b) a tissue-specific promoter, (c) a recombinase gene, (d) a foreign DNA, and (e) a recombinase site. The nucleic acid molecule may further comprise a gene which is desired to be incorporated into and expressed in a transgenic organism. The method can be used in both plants and animals, and has many applications as described herein.
摘要翻译： 本发明涉及以组织特异性方式缺失DNA序列的方法。 在一个实施方案中，在序列组织中特异性缺失DNA序列。 在第二个实施方案中，DNA序列在期望的体细胞组织中被特异性缺失。 本发明还涉及用于该方法的核酸分子。 更具体地说，本发明提供了一种核酸分子，其包含（a）重组酶位点，（b）组织特异性启动子，（c）重组酶基因，（d）外源DNA，和（e） 重组酶位点。 核酸分子可以进一步包含希望并入并在转基因生物体中表达的基因。 该方法可以在植物和动物中使用，并且具有如本文所述的许多应用。
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4.发明申请USE OF ANGIOTENSIN CONVERTING ENZYME (ACE) DOMAIN SPECIFIC INHIBITORS TO INHIBIT OR ENHANCE CYTOKINE PRODUCTION AND ALTER IMMUNE RESPONSE 审中-公开使用抗生素转化酶（ACE）特异性抑制剂抑制或增强细胞因子生产和增强免疫应答公开(公告)号：US20120088730A1
公开(公告)日：2012-04-12
申请号：US13375301
申请日：2010-06-02
申请人： Kenneth E. Bernstein , Chentao Lin
发明人： Kenneth E. Bernstein , Chentao Lin
IPC分类号： A61K31/662 , A61P29/00 , A61K38/07 , A61K31/675 , C12Q1/37
CPC分类号： A61K31/40
摘要： The present invention relates to the discovery that the two ACE domains can have very different effects on cytokine expression. In one embodiment, the present invention provides a method of regulating and/or treating a condition in a subject by administering a therapeutically effective dosage of site specific ACE inhibitor. In another embodiment, the condition is inflammation and/or immune response.
摘要翻译： 本发明涉及两个ACE结构域对细胞因子表达具有非常不同的影响的发现。 在一个实施方案中，本发明提供了通过施用治疗有效剂量的局部特异性ACE抑制剂来调节和/或治疗受试者的状况的方法。 在另一个实施方案中，该病症是炎症和/或免疫应答。
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