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公开(公告)号：US07197359B1
公开(公告)日：2007-03-27
申请号：US10110712
申请日：2000-04-06
IPC分类号： A61N1/30
CPC分类号： A61N1/30 , A61K9/0009
摘要： The present invention relates to compositions for electroporation which are useful in elevating percutaneous absorbability of drugs, etc. By controlling electrolyte concentration of compositions for electroporation so as to make an osmotic pressure of the compositions not more than a physical osmotic pressure, the percutaneous absorbability of drugs can be elevated.
摘要翻译： 本发明涉及电穿孔用组合物，其可用于提高药物的经皮吸收性等。通过控制用于电穿孔的组合物的电解质浓度，使得组合物的渗透压不超过物理渗透压，经皮吸收能力 药物可以升高。
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公开(公告)号：US07089053B1
公开(公告)日：2006-08-08
申请号：US10110590
申请日：2000-04-06
CPC分类号： A61N1/30 , A61K9/0009 , A61K9/0014 , A61K47/10
摘要： The present invention relates to compositions for electroporation which are useful in elevating a percutaneous absorbability of drugs, etc. By adding polyhydric alcohols to compositions for electroporation, the percutaneous absorbability of drugs is elevated.
摘要翻译： 本发明涉及电穿孔用组合物，其可用于提高药物的经皮吸收性等。通过将多元醇加入用于电穿孔的组合物中，药物的经皮吸收性提高。
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公开(公告)号：US06878548B2
公开(公告)日：2005-04-12
申请号：US10467971
申请日：2002-02-19
申请人： Yoshihiro Tokudome , Toshihiro Hinokitani , Kenichi Goto , Kenji Sugibayashi , Koji Owaku , Yasunori Inaoka
发明人： Yoshihiro Tokudome , Toshihiro Hinokitani , Kenichi Goto , Kenji Sugibayashi , Koji Owaku , Yasunori Inaoka
CPC分类号： A61K9/0009 , A61K47/02
摘要： The present invention is a composition for percutaneous administration suitable for electroporation. Percutaneous absorption of a drug and so forth in a composition for electroporation can be promoted by adding alkaline earth metal ions to the composition.
摘要翻译： 本发明是适用于电穿孔的经皮给药组合物。 通过向组合物中加入碱土金属离子可以促进用于电穿孔的组合物中药物等的经皮吸收。
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公开(公告)号：US06721595B1
公开(公告)日：2004-04-13
申请号：US10110589
申请日：2002-04-11
IPC分类号： A61N130
CPC分类号： A61N1/30 , A61K9/0009 , A61K9/0014 , A61K47/06
摘要： The present invention relates to percutaneous sorbefacients for electroporation consisting of monoterpene and being useful in elevating percutaneous absorbability of drugs, etc. By adding these percutaneous sorbefacients to compositions for electroporation, the percutaneous absorbability of drugs can be elevated.
摘要翻译： 本发明涉及由单萜组成的用于电穿孔的经皮吸收剂，可用于提高药物的经皮吸收性等。通过将这些经皮吸收剂加入到电穿孔组合物中，可以提高药物的经皮吸收性。
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5.发明申请NOVEL TRITERPENIC ACID DERIVATIVE AND PREPARATION FOR EXTERNAL APPLICATION FOR SKIN COMPRISING THE SAME 有权新颖的三聚磷酸衍生物和用于包含其的皮肤外用的制剂公开(公告)号：US20090075946A1
公开(公告)日：2009-03-19
申请号：US11912477
申请日：2006-04-13
IPC分类号： A61K31/661 , C07C61/08 , A61P17/00 , A61P29/00
CPC分类号： A61Q19/00 , A61K8/63 , A61K31/661 , A61Q19/02
摘要： In a triterpenic acid having hydroxyl groups, at least one of the hydroxyl groups is phosphorylated to produce a phosphorylated triterpenic acid and/or a salt thereof, thereby improving the solubility of the triterpenic acid in a preparation for external application for the skin and allowing the physiological activity of the triterpenic acid to be exerted satisfactorily. The phosphorylated triterpenic acid is preferably, for example, ursolic acid phosphate and/or a salt thereof. The preparation for external application for the skin is preferably a cosmetic, particularly preferably a quasi-drug.
摘要翻译： 在具有羟基的三萜酸中，至少一个羟基被磷酸化以产生磷酸化三萜酸和/或其盐，从而提高三萜酸在外用于皮肤的制剂中的溶解度，并允许 三萜酸的生理活性令人满意地发挥。 磷酸化三萜酸优选为例如熊果酸磷酸盐和/或其盐。 用于皮肤外用的制剂优选为化妆品，特别优选为准药物。
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6.发明授权公开(公告)号：US07718635B2
公开(公告)日：2010-05-18
申请号：US11912477
申请日：2006-04-13
CPC分类号： A61Q19/00 , A61K8/63 , A61K31/661 , A61Q19/02
摘要： In a triterpenic acid having hydroxyl groups, at least one of the hydroxyl groups is phosphorylated to produce a phosphorylated triterpenic acid and/or a salt thereof, thereby improving the solubility of the triterpenic acid in a preparation for external application for the skin and allowing the physiological activity of the triterpenic acid to be exerted satisfactorily. The phosphorylated triterpenic acid is preferably, for example, ursolic acid phosphate and/or a salt thereof. The preparation for external application for the skin is preferably a cosmetic, particularly preferably a quasi-drug.
摘要翻译： 在具有羟基的三萜酸中，至少一个羟基被磷酸化以产生磷酸化三萜酸和/或其盐，从而提高三萜酸在外用于皮肤的制剂中的溶解度，并允许 三萜酸的生理活性令人满意地发挥。 磷酸化三萜酸优选为例如熊果酸磷酸盐和/或其盐。 用于皮肤外用的制剂优选为化妆品，特别优选为准药物。
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公开(公告)号：US4689864A
公开(公告)日：1987-09-01
申请号：US843820
申请日：1986-03-28
CPC分类号： B21J5/12 , B21K1/20 , Y10S29/026 , Y10T29/49405 , Y10T29/49996
摘要： A method of making valve sleeves used for controlling the flow of hydraulic fluid in devices, such as power steering units in motorized vehicle, and the product of the utilized method. The method utilizes a grooving male die which forms a groove on an interior surface of a valve sleeve.
摘要翻译： 制造用于控制机动车辆中的动力转向装置等装置中的液压流体的流量的阀套的方法以及所使用的方法的乘积。 该方法利用在阀套的内表面上形成凹槽的开槽阳模。
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