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    PROCESS FOR PRODUCING PHOSPHORUS-CONTAINING DEHYDROAMINO ACID
    6.
    发明申请
    PROCESS FOR PRODUCING PHOSPHORUS-CONTAINING DEHYDROAMINO ACID 有权
    生产含磷酸脱氢山梨醇酸的方法

    公开(公告)号：US20110009662A1

    公开(公告)日：2011-01-13

    申请号：US12529953

    申请日：2008-03-19

    申请人： Kenichi Kurihara ,  Nobuto Minowa ,  Nozomu Nakanishi ,  Masaaki Mitomi

    发明人： Kenichi Kurihara ,  Nobuto Minowa ,  Nozomu Nakanishi ,  Masaaki Mitomi

    IPC分类号： C07C227/14

    CPC分类号： C07F9/4006 ,  C07F9/3217

    摘要： A process for efficiently producing through a small number of steps an N-substituted 2-amino-4-(substituted-oxymethylphosphinyl)-2-butenoic ester which is an intermediate for herbicide L-AMPB. The process comprises reacting a compound represented by the following formula (1): (where R1 represents C1-4 alkyl group) with a compound represented by the following formula (2): (wherein R2, R2′, and R3 each represents C1-4 alkyl and R4 represents benzyloxycarbonyl) in the presence of a base.

    摘要翻译： 通过少量步骤有效地制备作为除草剂L-AMPB的中间体的N-取代的2-氨基-4-（取代的 - 氧甲基氧膦基）-2-丁烯酸酯的方法。 该方法包括使由下式（1）表示的化合物（其中R 1表示C 1-4烷基）与下式（2）表示的化合物反应：（其中R2，R2'和R3各自表示C1- 4烷基，R 4表示苄氧基羰基）。

    Process for producing phosphorus-containing dehydroamino acid
    7.
    发明授权
    Process for producing phosphorus-containing dehydroamino acid 有权
    生产含磷脱氢氨基酸的方法

    公开(公告)号：US08329935B2

    公开(公告)日：2012-12-11

    申请号：US12529953

    申请日：2008-03-19

    申请人： Kenichi Kurihara ,  Nobuto Minowa ,  Nozomu Nakanishi ,  Masaaki Mitomi

    发明人： Kenichi Kurihara ,  Nobuto Minowa ,  Nozomu Nakanishi ,  Masaaki Mitomi

    IPC分类号： C07F9/28

    CPC分类号： C07F9/4006 ,  C07F9/3217

    摘要： A process for efficiently producing through a small number of steps an N-substituted 2-amino-4-(substituted-oxymethylphosphinyl)-2-butenoic ester which is an intermediate for herbicide L-AMPB. The process comprises reacting a compound represented by the following formula (1): (where R1 represents C1-4 alkyl group) with a compound represented by the following formula (2): (wherein R2, R2′, and R3 each represents C1-4 alkyl and R4 represents benzyloxycarbonyl) in the presence of a base.

    摘要翻译： 通过少量步骤有效地制备作为除草剂L-AMPB的中间体的N-取代的2-氨基-4-（取代的 - 氧甲基氧膦基）-2-丁烯酸酯的方法。 该方法包括使由下式（1）表示的化合物（其中R 1表示C 1-4烷基）与下式（2）表示的化合物反应：（其中R2，R2'和R3各自表示C1- 4烷基，R 4表示苄氧基羰基）。

    PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE AMINOPHOSPHINYLBUTANOIC ACIDS
    8.
    发明申请
    PROCESS FOR PRODUCTION OF OPTICALLY ACTIVE AMINOPHOSPHINYLBUTANOIC ACIDS 有权
    生产光学活性氨基磷酰胆碱的方法

    公开(公告)号：US20090221851A1

    公开(公告)日：2009-09-03

    申请号：US12298067

    申请日：2007-09-03

    申请人： Nobuto Minowa ,  Nozomu Nakanishi ,  Masaaki Mitomi ,  Hideki Nara ,  Tohru Yokozawa

    发明人： Nobuto Minowa ,  Nozomu Nakanishi ,  Masaaki Mitomi ,  Hideki Nara ,  Tohru Yokozawa

    IPC分类号： C07F9/28

    CPC分类号： C07B53/00 ,  C07F9/301 ,  C07F9/3211

    摘要： The present invention is a process for producing optically active aminophosphinylbutanoic acids represented by the formula (2) (in the formula (2), R1 represents an alkyl group having 1 to 4 carbon atom(s), R2 represents hydrogen atom or an alkyl group having 1 to 4 carbon atom(s), R3 represents an alkyl group having 1 to 4 carbon atom(s), an alkoxy group having 1 to 4 carbon atom(s), an aryl group, an aryloxy group, or a benzyloxy group, and R4 represents hydrogen atom or an alkyl group having 1 to 4 carbon atom(s); and * represents an asymmetric carbon atom), wherein a compound represented by the formula (1) (in the formula (1), R1 represents an alkyl group having 1 to 4 carbon atom(s), R2 represents hydrogen atom or an alkyl group having 1 to 4 carbon atom(s), R3 represents an alkyl group having 1 to 4 carbon atom(s), an alkoxy group having 1 to 4 carbon atom(s), an aryl group, an aryloxy group, or a benzyloxy group, and R4 represents hydrogen atom or an alkyl group having 1 to 4 carbon atom(s)) is asymmetrically hydrogenated in the presence of a ruthenium-optically active phosphine complex. With the process for the production, a compound useful in a herbicide such as L-AHPB can be produced with good efficiency and high asymmetric yield.

    摘要翻译： 本发明是一种由式（2）表示的光学活性氨基氧膦基丁酸的制备方法（式（2）中，R 1表示碳原子数1〜4的烷基，R 2表示氢原子或烷基 具有1至4个碳原子，R 3表示具有1至4个碳原子的烷基，具有1至4个碳原子的烷氧基，芳基，芳氧基或苄氧基 R4表示氢原子或碳原子数1〜4的烷基，*表示不对称碳原子），式（1）表示的化合物（式（1）中，R 1表示 具有1至4个碳原子的烷基，R 2表示氢原子或具有1至4个碳原子的烷基，R 3表示具有1至4个碳原子的烷基，具有1个 至4个碳原子，芳基，芳氧基或苄氧基，R 4表示氢原子或1-4个碳原子的烷基 在一种钌光学活性膦配合物的存在下，不对称氢化。 通过制备方法，可以以高效率和高不对称产率制备可用于除草剂如L-AHPB的化合物。

    Method for producing L-2-amino-4-(hydroxymethylphosphinyl)-butanoic acid
    10.
    发明授权
    Method for producing L-2-amino-4-(hydroxymethylphosphinyl)-butanoic acid 有权
    制备L-2-氨基-4-（羟甲基氧膦基） - 丁酸的方法

    公开(公告)号：US07772426B2

    公开(公告)日：2010-08-10

    申请号：US11909839

    申请日：2006-03-28

    申请人： Nobuto Minowa ,  Nozomu Nakanishi ,  Masaaki Mitomi

    发明人： Nobuto Minowa ,  Nozomu Nakanishi ,  Masaaki Mitomi

    IPC分类号： C07C227/32

    CPC分类号： C07B53/00 ,  C07F9/301 ,  C07F9/65683

    摘要： Disclosed is a method for efficiently and highly selectively producing L-2-amino-4-(hydroxymethylphosphinyl)-butanoic acid, which is useful as a herbicide, through a catalytic asymmetric synthesis reaction. Specifically disclosed is a method for producing L-2-amino-4-(hydroxymethylphosphinyl)-butanoic acid which is characterized in that a dehydroamino acid is subjected to an asymmetric hydrogenation by using a rhodium catalyst represented by the formula (2) below and having an optically active cyclic phosphine ligand, and then the resulting product is subjected to hydrolysis: [Rh(R4)(L)]X  (2) [where R4 represents 1,5-cyclooctadien or norbornadien; L represents a substance represented by the following formula (6): (wherein R5 and R8 respectively represent a C1-4 alkyl group; R6 and R7 respectively represent hydrogen atom or hydroxyl group; and Y represents a group selected from groups represented by the following formula (7): (where Me represents methyl group)).].

    摘要翻译： 公开了通过催化不对称合成反应有效和高选择性地生产可用作除草剂的L-2-氨基-4-（羟甲基氧膦基） - 丁酸的方法。 具体公开了一种生产L-2-氨基-4-（羟甲基氧膦基） - 丁酸的方法，其特征在于，使用下式（2）表示的铑催化剂对脱氢氨基酸进行不对称氢化， 光学活性环膦配体，然后使所得产物水解：[Rh（R 4）（L）] X（2）[其中R 4表示1,5-环辛二烯或降冰片素; L表示由下式（6）表示的物质：（其中，R 5和R 8分别表示C 1-4烷基; R 6和R 7分别表示氢原子或羟基，Y表示选自下述 式（7）：（Me表示甲基））。