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    METHOD FOR PRODUCING GLUFOSINATE P FREE ACID
    7.
    发明申请
    METHOD FOR PRODUCING GLUFOSINATE P FREE ACID 有权
    生产谷氨酸磷酸的方法

    公开(公告)号：US20140309453A1

    公开(公告)日：2014-10-16

    申请号：US14348376

    申请日：2012-09-28

    申请人： MEIJI SEIKA PHARMA CO., LTD.

    发明人： Nozomu Nakanishi ,  Takashi Ando ,  Nobuto Minowa ,  Masaaki Mitomi

    IPC分类号： C07F9/30

    CPC分类号： C07F9/301 ,  C07B2200/13

    摘要： The present invention provides a method for producing crystalline glufosinate P free acid with high purity from glufosinate P hydrochloride salt. In addition, the present invention also provides a method comprises a process of: dissolving glufosinate P hydrochloride salt in a solvent which is a mixed solvent of water and an alcohol(s) selected from the group of methanol, ethanol, propyl alcohol and isopropyl alcohol, and a ratio of water to the alcohol(s) is from 1:3 to 1:100 by volume; crystallizing glufosinate P free acid after neutralizing by addition of a base.

    摘要翻译： 本发明提供从草铵膦P盐酸盐生产高纯度结晶草铵膦P游离酸的方法。 此外，本发明还提供了一种方法，其包括以下方法：将草铵膦P盐酸盐溶解在溶剂中，所述溶剂是水和选自甲醇，乙醇，丙醇和异丙醇的醇的混合溶剂 ，水与醇的比例为1：3〜1：100; 通过添加碱中和后结晶草铵膦P游离酸。

    Process for the preparation of highly purified, dialkydithiophosphinic compounds
    8.
    发明授权
    Process for the preparation of highly purified, dialkydithiophosphinic compounds 有权
    制备高纯度二烷基二硫代磷酸化合物的方法

    公开(公告)号：US08796487B2

    公开(公告)日：2014-08-05

    申请号：US12455847

    申请日：2009-06-08

    申请人： Leo Zhaoqing Liu ,  Gary Woodward

    发明人： Leo Zhaoqing Liu ,  Gary Woodward

    IPC分类号： C07F9/34 ,  C07F9/30

    CPC分类号： C07F9/34 ,  C07F9/301

    摘要： An improved process for production of dialkyldithiophosphinic acid including sulfurizing a purified dialkylphosphinic acid by: reacting a hypophosphorous acid or salt with a stoichiometric excess of an alpha olefin in the presence of a free radical initiator to form a reaction product comprising monoalkylphosphinic acid and dialkylphosphinic acid; adding sufficient aqueous base to the reaction product to i) form the salts of the phosphinic acids, and ii) establish an aqueous phase and an organic phase, wherein a monoalkylphosphinic acid solubilizes into an aqueous phase; separating the organic phase from the aqueous phase; acidifying the organic phase and removing the olefin from the organic phase; isolating the purified dialkylphosphinic acid product; and sulfurizing the purified dialkylphosphinic acid product to form a dialkydithiophosphinic acid. The present invention also provides a process for preparing purified dialkylthiophosphinic chloride, and a process for preparing purified dialkylmonothiophosphinic acids.

    摘要翻译： 一种制备二烷基二硫代次膦酸的改进方法，包括通过以下方法硫化纯化的二烷基次膦酸：在自由基引发剂的存在下使次磷酸或盐与化学计量过量的α-烯烃反应形成包含单烷基次膦酸和二烷基次膦酸的反应产物; 向反应产物中加入足够的碱水溶液以i）形成次膦酸的盐，和ii）建立水相和有机相，其中单烷基次膦酸溶于水相中; 从水相中分离有机相; 酸化有机相并从有机相中除去烯烃; 分离纯化的二烷基次膦酸产物; 并将纯化的二烷基次膦酸产物硫化以形成二烷基次膦酸。 本发明还提供了一种制备纯化的二烷基硫代次膦酸氯化物的方法和一种制备纯化的二烷基硫代次膦酸的方法。

    METHODS AND COMPOSITIONS FOR PRODUCING AND SELECTING TRANSGENIC PLANTS
    9.
    发明申请
    METHODS AND COMPOSITIONS FOR PRODUCING AND SELECTING TRANSGENIC PLANTS 审中-公开
    生产和选择转基因植物的方法和组合物

    公开(公告)号：US20140173775A1

    公开(公告)日：2014-06-19

    申请号：US13800447

    申请日：2013-03-13

    申请人： PIONEER HI-BRED INTERNATIONAL, INC.

    发明人： Myeong-Je Cho ,  Samuel R. Ellis ,  William J. Gordon-Kamm ,  Zuo-Yo Zhoa

    IPC分类号： C12N15/82 ,  C12Q1/68

    CPC分类号： C12N15/8237 ,  C07F9/301 ,  C07F9/3813 ,  C12N15/8209 ,  C12N15/821 ,  C12N15/8212 ,  C12N15/8213 ,  C12N15/8216 ,  C12N15/8217 ,  C12N15/8238 ,  C12N15/8274 ,  C12N15/8275 ,  C12Q1/6895

    摘要： Compositions and methods are provided for the production and selection of transgenic plants and plant parts, for increasing the transformation frequency of a plant or plant part, and for regulating the expression of a transgene, such as a herbicide tolerance polynucleotide. The methods and compositions allow for the delay in the expression of herbicide tolerance polynucleotides until a point in development during which herbicide selection is more efficient. Compositions comprise polynucleotide constructs comprising an excision cassette that separates a transgene, such as a herbicide tolerance polynucleotide, from its promoter and host cells comprising the same. The excision cassette comprises a polynucleotide encoding a site-specific recombinase operably linked to an inducible promoter and expression of the recombinase leads to excision of the excision cassette and expression of the transgene.

    摘要翻译： 提供用于生产和选择转基因植物和植物部分的组合物和方法，用于增加植物或植物部分的转化频率，以及调节转基因的表达，例如除草剂耐受性多核苷酸。 所述方法和组合物允许除草剂耐受性多核苷酸的表达的延迟直到除草剂选择更有效的发育点。 组合物包含多核苷酸构建体，其包含从其启动子和包含其的宿主细胞分离转基因，例如除草剂耐受性多核苷酸的切除盒。 切除盒包含编码可操作地连接到诱导型启动子的位点特异性重组酶的多核苷酸，并且重组酶的表达导致切除盒的切除和转基因的表达。

    Aminophosphinic derivatives that can be used in the treatment of pain
    10.
    发明授权
    Aminophosphinic derivatives that can be used in the treatment of pain 有权
    可用于治疗疼痛的氨基亚磷酸衍生物

    公开(公告)号：US08703747B2

    公开(公告)日：2014-04-22

    申请号：US13055096

    申请日：2009-07-22

    申请人： Bernard Roques ,  Hervé Poras ,  Marie-Claude Fournie-Zaluski

    发明人： Bernard Roques ,  Hervé Poras ,  Marie-Claude Fournie-Zaluski

    IPC分类号： A61K31/66 ,  A01N57/00 ,  A01N57/18

    CPC分类号： C07F9/306 ,  A61K31/662 ,  A61K31/67 ,  A61K31/675 ,  A61K39/08 ,  A61K45/06 ,  C07F9/301 ,  C07F9/303 ,  C07F9/3211 ,  C07F9/3241 ,  C07F9/4816 ,  C07F9/59 ,  C07F9/655345

    摘要： The present invention relates to a compound of the following general formula (I): R1—NH—CH(R2)—P(═O)(OR3)—CH2—C(R4)(R5)—CONH—CH(R6)—COOR7 (I) or a pharmaceutically acceptable salt of the latter, an isomer or a mixture of isomers in any proportions, especially a mixture of enantiomers, and in particular a racemic mixture, for which R1 represents a —C(═O)—O—C(R8)(R9)—OC(═O)—R10 group; R2 represents an optionally substituted hydrocarbon-based chain, an aryl or heteroaryl group or a methylene group substituted by a heterocycle; R3 represents a hydrogen atom or a —C(R12)(R13)—OC(═O)—R14 group; R4 and R5 form, together with the carbon that bears them, a saturated hydrocarbon-based ring or an optionally substituted piperidine ring or R4 represents a hydrogen atom and R5 represents a phenyl or a benzyl that is optionally substituted, a heteroaromatic ring or a methylene group substituted by a heterocycle; R6 represents an optionally substituted hydrocarbon-based chain or a phenyl or a benzyl that is optionally substituted; and R7 represents a hydrogen atom or a benzyl, alkyl, heteroaryl, alkylheteroaryl, —CHMe—COOR18, —CHR19—OC(═O)OR20 and —CHR19—OC(═O)OR20 group. The present invention also relates to the use of these compounds as a medicinal product, and in particular for the treatment of pain, more advantageously neuropathic and neuroinflammatory pain, to their method of synthesis and also to the compositions containing them.

    摘要翻译： 本发明涉及以下通式（I）的化合物：R1-NH-CH（R2）-P（= O）（OR3）-CH2-C（R4）（R5）-CONH-CH（R6） -COOR7（I）或其后者的药学上可接受的盐，任何比例的异构体或异构体混合物，特别是对映异构体的混合物，特别是外消旋混合物，其中R1表示-C（= O） - O-C（R 8）（R 9）-OC（= O）-R 10基; R2表示任选取代的烃基链，芳基或杂芳基或被杂环取代的亚甲基; R3表示氢原子或-C（R12）（R13）-OC（= O）-R14基团; R4和R5与带有它们的碳一起形成饱和烃基环或任选取代的哌啶环，或R4表示氢原子，R 5表示任选取代的苯基或苄基，杂芳环或亚甲基 被杂环取代的基团; R6表示任选取代的烃基链或任选取代的苯基或苄基; 并且R 7表示氢原子或苄基，烷基，杂芳基，烷基杂芳基，-CHMe-COOR 18，-CHR 19 -OC（= O）OR 20和-CHR 19 -OC（= O）OR 20基团。 本发明还涉及这些化合物作为药用产品的用途，特别是用于治疗其合成方法的疼痛，更有利的是神经性和神经炎性疼痛，以及含有它们的组合物。