公开(公告)号：US06245897B1

公开(公告)日：2001-06-12

申请号：US09262313

申请日：1999-03-04

申请人： Yoshiyuki Adachi ,  Naohito Ohno ,  Toshiro Yadomae

发明人： Yoshiyuki Adachi ,  Naohito Ohno ,  Toshiro Yadomae

IPC分类号： C12P2108

CPC分类号： C07K16/2896

摘要： A monoclonal antibody which recognizes lipopolysaccharide binding site of macrophage cell surface receptor CD14 and has binding activity to monocyte or macrophage cells. The monoclonal antibody suppresses the production of an inflammatory mediator such as TNF, IL-6 or NO at early stages by recognizing CD14, and competitively inhibiting its binding with LPS. Therefore, it is useful for pathology analysis and the treatment of sepsis.

摘要翻译： 识别巨噬细胞表面受体CD14的脂多糖结合位点并对单核细胞或巨噬细胞具有结合活性的单克隆抗体。 单克隆抗体通过识别CD14在早期抑制炎性介质如TNF，IL-6或NO的产生，并且竞争性地抑制其与LPS的结合。 因此，对于病理分析和脓毒症治疗是有用的。