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    Monoclonal antibody recognizing cell surface antigen CD14
    1.
    发明授权
    Monoclonal antibody recognizing cell surface antigen CD14 有权
    单克隆抗体识别细胞表面抗原CD14

    公开(公告)号：US06245897B1

    公开(公告)日：2001-06-12

    申请号：US09262313

    申请日：1999-03-04

    申请人： Yoshiyuki Adachi ,  Naohito Ohno ,  Toshiro Yadomae

    发明人： Yoshiyuki Adachi ,  Naohito Ohno ,  Toshiro Yadomae

    IPC分类号： C12P2108

    CPC分类号： C07K16/2896

    摘要： A monoclonal antibody which recognizes lipopolysaccharide binding site of macrophage cell surface receptor CD14 and has binding activity to monocyte or macrophage cells. The monoclonal antibody suppresses the production of an inflammatory mediator such as TNF, IL-6 or NO at early stages by recognizing CD14, and competitively inhibiting its binding with LPS. Therefore, it is useful for pathology analysis and the treatment of sepsis.

    摘要翻译： 识别巨噬细胞表面受体CD14的脂多糖结合位点并对单核细胞或巨噬细胞具有结合活性的单克隆抗体。 单克隆抗体通过识别CD14在早期抑制炎性介质如TNF，IL-6或NO的产生，并且竞争性地抑制其与LPS的结合。 因此，对于病理分析和脓毒症治疗是有用的。

    Methods for producing recombinant polyclonal immunoglobulins
    5.
    发明申请
    Methods for producing recombinant polyclonal immunoglobulins 审中-公开
    重组多克隆免疫球蛋白的制备方法

    公开(公告)号：US20050260710A1

    公开(公告)日：2005-11-24

    申请号：US11092988

    申请日：2005-03-30

    申请人： Kazuo Suzuki ,  Masahiro Furutani ,  Kenji Yamamoto ,  Naohito Ohno ,  Kei Takahashi ,  Yasuaki Aratani ,  Akiko Togi

    发明人： Kazuo Suzuki ,  Masahiro Furutani ,  Kenji Yamamoto ,  Naohito Ohno ,  Kei Takahashi ,  Yasuaki Aratani ,  Akiko Togi

    IPC分类号： C07K16/00 ,  C07K16/44 ,  C12N1/21 ,  C12N15/74 ,  C12P21/06

    CPC分类号： C07K16/00 ,  A61K2039/505 ,  C07K2317/52 ,  C07K2317/622 ,  C07K2319/00

    摘要： The purpose of the present invention is to provide methods for producing recombinant polyclonal immunoglobulins using recombinant DNA techniques, which provides constant supply of immunoglobulin preparations with minimum risk of infection. A method of the present invention comprises the following steps: (1) isolating a plurality of types of genes from cDNAs derived from tissues or cells expressing immunoglobulins, said genes encoding a plurality of types of polypeptides respectively, and said polypeptides containing a plurality of types of immunoglobulin variable regions respectively, and preparing mixture of the genes; (2) preparing a plurality of types of recombinant vectors into which a plurality of types of genes are introduced respectively by contacting said mixture of the genes with vectors, and preparing mixture of the recombinant vectors; (3) preparing a plurality of types of transformants into which a plurality of types of recombinant vectors are introduced respectively by contacting said mixture of the recombinant vectors with host cells, and preparing mixture of the transformants; and (4) culturing said mixture of the transformants, and obtaining mixture of polypeptides from the transformants culture, wherein said polypeptides contain a plurality of types of immunoglobulin variable regions respectively.

    摘要翻译： 本发明的目的是提供使用重组DNA技术制备重组多克隆免疫球蛋白的方法，其提供具有最小感染风险的免疫球蛋白制剂的恒定供应。 本发明的方法包括以下步骤：（1）从衍生自表达免疫球蛋白的组织或细胞的cDNA分离多种类型的基因，所述基因分别编码多种类型的多肽，所述多肽含有多种类型 的免疫球蛋白可变区，并制备基因的混合物; （2）通过将所述基因混合物与载体接触，制备多种类型的重组载体，其中分别导入多种类型的基因，并制备重组载体的混合物; （3）通过使重组载体的混合物与宿主细胞接触，制备分别引入多种类型的重组载体的多种类型的转化体，并制备转化体的混合物; （4）培养所述转化体的所述混合物，并从所述转化体培养物获得多肽的混合物，其中所述多肽分别含有多种类型的免疫球蛋白可变区。

    Agent for the prevention and/or treatment of septicemia
    6.
    发明申请
    Agent for the prevention and/or treatment of septicemia 审中-公开
    用于预防和/或治疗败血症的药剂

    公开(公告)号：US20050191373A1

    公开(公告)日：2005-09-01

    申请号：US11058633

    申请日：2005-02-16

    申请人： Naohito Ohno ,  Susumu Masuda

    发明人： Naohito Ohno ,  Susumu Masuda

    IPC分类号： A23L2/38 ,  A23L1/30 ,  A23L2/52 ,  A61K8/49 ,  A61K8/96 ,  A61K8/97 ,  A61K8/99 ,  A61K9/00 ,  A61K31/352 ,  A61K35/74 ,  A61K36/00 ,  A61K36/48 ,  A61K47/00 ,  A61P31/00 ,  A61P31/10 ,  C07D311/36 ,  A61K35/78

    CPC分类号： A61K9/0095 ,  A23L33/105 ,  A23V2002/00 ,  A61K36/48 ,  A23V2200/324 ,  A23V2250/5488 ,  A23V2250/2116

    摘要： The purpose of the invention is to provide an agent for the prevention or treatment of septicemia caused by the infection of microorganism. The present invention relates to: (1) an agent for the prevention and/or treatment of septicemia caused by the infection of microorganism, comprising soybean extract or soybean fermented product as an effective; (2) An agent for the prevention and/or treatment of septicemia caused by the infection of microorganism, comprising isoflavone as an effective component; and (3) Food and drink, medicine, or cosmetics, comprising the agent for the prevention and/or treatment according to the above (1) or (2). The agent according to the present invention, which has a high suppressing activity of the abnormal production of TNF-α, is useful in the fields of medicines, cosmetics and foods, especially for the profundus mycosis patient.

    摘要翻译： 本发明的目的是提供一种用于预防或治疗由微生物感染引起的败血症的药剂。 本发明涉及：（1）用于预防和/或治疗由微生物感染引起的败血病的药剂，其包含大豆提取物或大豆发酵产品作为有效的; （2）预防和/或治疗由异黄酮作为有效成分的微生物感染引起的败血症的药剂; 和（3）包含根据上述（1）或（2）的预防和/或治疗剂的食品和饮料，药物或化妆品。 具有高的TNF-α异常产生抑制活性的本发明的药剂可用于药物，化妆品和食品领域，特别是对于真菌性真菌病患者。