公开(公告)号：US4902700A

公开(公告)日：1990-02-20

申请号：US279225

申请日：1988-11-28

申请人： Yosio Hayasi ,  Tomei Oguri ,  Masaki Shimoda ,  Mikio Tsutsui ,  Kazuo Takahashi ,  Hitoshi Miida

发明人： Yosio Hayasi ,  Tomei Oguri ,  Masaki Shimoda ,  Mikio Tsutsui ,  Kazuo Takahashi ,  Hitoshi Miida

IPC分类号： C07D417/12 ,  A61K31/425 ,  A61K31/426 ,  A61K31/428 ,  A61P37/08 ,  A61P43/00 ,  C07D277/20 ,  C07D277/22 ,  C07D277/24 ,  C07D277/28 ,  C07D277/30 ,  C07D277/56 ,  C07D277/64 ,  C07D277/82

CPC分类号： C07D277/82 ,  C07D277/24 ,  C07D277/28 ,  C07D277/30 ,  C07D277/56 ,  C07D277/64

摘要： Disclosed are a thiazole derivative represented by the following formula, a pharmaceutically acceptable salt thereof and leukotriene antagonist containing the same as the active ingredients: ##STR1## wherein R.sub.1 and R.sub.2 each independently represent a hydrogen atom, an alkyl group having 1 to 8 carbon atoms, a lower alkoxycarbonyl group or a substituted or unsubstituted phenyl group or cooperatively represent a tetramethylene group corresponding to a fused cyclohexane ring or a butadienylene group which is unsubstituted or substituted with a halogen atom, a lower alkoxy group, a lower alkoxycarbonyl group or an alkyl group having 1 to 3 carbon atoms corresponding to a fused benzene ring; R.sub.3, R.sub.4, R.sub.5 and R.sub.6 each independently represent a hydrogen atom, a hydroxyl group, a lower alkoxy group, an alkyl group having 1 to 3 carbon atoms or a halogen atom; A represents a linking group having 2 to 4 chain members; B represents a linking group having 2 to 5 chain members; and Q represents a carboxyl group, a lower alkoxy group, a hydroxyl group, an alkoxycarbonyl group having 2 to 6 carbon atoms or a 5-tetrazolyl group.

摘要翻译： 公开了由下式表示的噻唑衍生物，其药学上可接受的盐和含有与活性成分相同的白三烯拮抗剂：其中R 1和R 2各自独立地表示氢原子，具有1至8个碳原子的烷基 低级烷氧基羰基或取代或未取代的苯基，或协同表示对应于未被取代或被卤素原子，低级烷氧基，低级烷氧基羰基或烷基取代的稠环己烷环或丁二烯基的四亚甲基 对应于稠合苯环的具有1至3个碳原子的基团; R 3，R 4，R 5和R 6各自独立地表示氢原子，羟基，低级烷氧基，碳原子数1〜3的烷基或卤素原子。 A表示具有2至4个链成员的连接基团; B表示具有2至5个链成员的连接基团; Q表示羧基，低级烷氧基，羟基，碳原子数2〜6的烷氧基羰基或5-四唑基。