公开(公告)号：US20110160190A1

公开(公告)日：2011-06-30

申请号：US13040614

申请日：2011-03-04

申请人： Young-Choon MOON ,  Liangxian CAO ,  Nadarajan TAMILARASU ,  Hongyan QI ,  Soongyu CHOI ,  William Joseph LENNOX ,  Donald Thomas CORSON ,  Seongwoo HWANG ,  Thomas DAVIS

发明人： Young-Choon MOON ,  Liangxian CAO ,  Nadarajan TAMILARASU ,  Hongyan QI ,  Soongyu CHOI ,  William Joseph LENNOX ,  Donald Thomas CORSON ,  Seongwoo HWANG ,  Thomas DAVIS

IPC分类号： A61K31/551 ,  A61K31/497 ,  A61K31/437 ,  A61K31/506 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/541 ,  A61P35/00

CPC分类号： A61K31/337 ,  A61K31/4353 ,  A61K31/437 ,  A61K31/444 ,  A61K31/497 ,  A61K31/506 ,  A61K31/513 ,  A61K31/5377 ,  A61K31/541 ,  A61K31/5513 ,  G01N2333/475 ,  G01N2333/515 ,  A61K2300/00

摘要： In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the treatment of solid tumor cancer, and in reducing plasma and/or tumor VEGF levels, are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the treatment of cancer, and the reduction of plasma and/or tumor VEGF levels, using the compounds of the invention.

摘要翻译： 根据本发明，已经鉴定了抑制VEGF转录后表达的化合物，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于抑制VEGF产生，治疗实体瘤癌症和降低血浆和/或肿瘤VEGF水平的化合物。 在本发明的另一方面，提供了使用本发明化合物抑制VEGF产生，治疗癌症以及降低血浆和/或肿瘤VEGF水平的方法。

公开(公告)号：US20090227618A2

公开(公告)日：2009-09-10

申请号：US11079420

申请日：2005-03-15

申请人： Young-Choon MOON ,  Liangxian CAO ,  Nadarajan TAMILARASU ,  Hongyan QI ,  Soongyu CHOI ,  William LENNOX ,  Donald CORSON ,  Seongwoo HWANG

发明人： Young-Choon MOON ,  Liangxian CAO ,  Nadarajan TAMILARASU ,  Hongyan QI ,  Soongyu CHOI ,  William LENNOX ,  Donald CORSON ,  Seongwoo HWANG

IPC分类号： A61K31/4745

CPC分类号： A61K31/506 ,  A61K31/437 ,  A61K31/4745 ,  A61K31/497 ,  A61K31/5355 ,  A61K31/541 ,  A61K31/551 ,  C07D471/04

摘要： In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.

公开(公告)号：US20070281962A2

公开(公告)日：2007-12-06

申请号：US11079420

申请日：2005-03-15

申请人： Young-Choon MOON ,  Liangxian CAO ,  Nadarajan TAMILARASU ,  Hongyan QI ,  Soongyu CHOI ,  William LENNOX ,  Donald CORSON ,  Seongwoo HWANG

发明人： Young-Choon MOON ,  Liangxian CAO ,  Nadarajan TAMILARASU ,  Hongyan QI ,  Soongyu CHOI ,  William LENNOX ,  Donald CORSON ,  Seongwoo HWANG

IPC分类号： A61K31/4745

CPC分类号： A61K31/506 ,  A61K31/437 ,  A61K31/4745 ,  A61K31/497 ,  A61K31/5355 ,  A61K31/541 ,  A61K31/551 ,  C07D471/04

摘要： In accordance with the present invention, compounds that inhibit the expression of VEGF post-transcriptionally have been identified, and methods for their use provided. In one aspect of the invention, compounds useful in the inhibition of VEGF production, in the inhibition of angiogenesis, and/or in the treatment of cancer, diabetic retinopathy or exudative macular degeneration are provided. In another aspect of the invention, methods are provided for the inhibition of VEGF production, the inhibition of angiogenesis, and/or the treatment of cancer, diabetic retinopathy or exudative macular degeneration using the compounds of the invention.

摘要翻译： 根据本发明，已经鉴定了抑制VEGF转录后表达的化合物，并提供了它们的使用方法。 在本发明的一个方面，提供了可用于抑制VEGF产生，抑制血管发生和/或治疗癌症，糖尿病性视网膜病变或渗出性黄斑变性的化合物。 在本发明的另一方面，提供了使用本发明化合物抑制VEGF产生，抑制血管发生和/或治疗癌症，糖尿病性视网膜病变或渗出性黄斑变性的方法。