公开(公告)号：US20050013857A1

公开(公告)日：2005-01-20

申请号：US10841979

申请日：2004-05-07

申请人： Yourong Fu ,  Chaul Pai ,  Sang Park ,  Gun Seomoon ,  Kinam Park

发明人： Yourong Fu ,  Chaul Pai ,  Sang Park ,  Gun Seomoon ,  Kinam Park

IPC分类号： A61K9/00 ,  A61K9/20

CPC分类号： A61K9/0056

摘要： A fast-melting pharmaceutical tablet comprises a porous, plastic substance, a water penetration enhancer and a binder. One or more drugs can be incorporated into the formulation at different stages of the process so as to afford a pharmaceutically active tablet. Methods of making the pharmaceutical tablet entail combining the porous, plastic material, the water penetration enhancing agent, and the binder so as to form highly plastic granules, which are compressed into tablets. The resulting tablets dissolve rapidly in the mouth and have good hardness with low brittleness. The tablets are particularly valuable to those who have difficulty swallowing conventional pills.

摘要翻译： 快速熔化的药物片剂包括多孔塑料物质，水渗透增强剂和粘合剂。 可以在该方法的不同阶段将一种或多种药物并入制剂中，从而得到药用活性片剂。 制备药片的方法需要结合多孔，塑料，水渗透增强剂和粘合剂，以形成高度塑性的颗粒，将其压制成片剂。 所得片剂迅速溶于口中，硬度好，脆性低。 这些片剂对吞咽常规药丸有困难的人特别有价值。

公开(公告)号：US20060134195A1

公开(公告)日：2006-06-22

申请号：US10536197

申请日：2003-11-25

申请人： Yourong Fu ,  Seong Jeong ,  Jeanny Kim ,  Jacqueline Callihan ,  Kinam Park ,  Chaul Pai ,  Sang Yeob Park ,  Gun Seomoon

发明人： Yourong Fu ,  Seong Jeong ,  Jeanny Kim ,  Jacqueline Callihan ,  Kinam Park ,  Chaul Pai ,  Sang Yeob Park ,  Gun Seomoon

IPC分类号： A61K9/20

CPC分类号： A61K9/2018 ,  A61K9/0056 ,  A61K9/2095

摘要： Fast-dissolving pharmaceutical tablets comprising mannose are described. The mannose component imparts both structure-forming and fast-dissolution properties to the tablets. Granulation of tablet components and humidification forms strong liquid bridges at the surface interfaces of mannose particles, which leads to strengthened tablets. The mannose particles, however, remain porous following compression so that contact with moisture, e.g., saliva in the mouth, leads rapidly to tablet disintegration and dissolution.

摘要翻译： 描述了包含甘露糖的快速溶解药物片剂。 甘露糖组分赋予片剂两者的结构形成和快速溶解性质。 片剂成分的成粒和加湿在甘露糖颗粒的表面界面形成强的液体桥，从而导致强化片剂。 然而，压缩后，甘露糖颗粒保持多孔，使得与水分例如口中的唾液接触迅速导致片剂崩解和溶解。