公开(公告)号：US07994158B2

公开(公告)日：2011-08-09

申请号：US12265599

申请日：2008-11-05

Applicant: Yu-Jen Chen ,  Cheng-Jen Chou ,  Tun-Tschu Chang

Inventor： Yu-Jen Chen ,  Cheng-Jen Chou ,  Tun-Tschu Chang

IPC: A01N45/00 ,  A61K31/56

CPC classification number: A61K31/575

Abstract: The present invention relates to a method for inhibiting tumor growth, in particular to the method using dehydrosulphurenic acid to inhibit the growth of leukemia cell or pancreatic cancer cell by a compound extracted and purified from Antrodia cinnamomea. Dehydrosulphurenic acid of the invention can be used as a pharmaceutical composition to inhibit the tumor growth of leukemia or pancreatic cancer.

Abstract translation: 本发明涉及一种抑制肿瘤生长的方法，特别是涉及使用脱氢硫代酸通过从番茄红素提取和纯化的化合物抑制白血病细胞或胰腺癌细胞生长的方法。 本发明的脱氢硫酸可以用作抑制白血病或胰腺癌肿瘤生长的药物组合物。

公开(公告)号：US08546366B2

公开(公告)日：2013-10-01

申请号：US13483620

申请日：2012-05-30

Applicant: Yu-Jen Chen ,  Cheng-Jen Chou ,  Tun-Tschu Chang

Inventor： Yu-Jen Chen ,  Cheng-Jen Chou ,  Tun-Tschu Chang

IPC: A61K31/56 ,  A61K38/00 ,  A61P35/00

CPC classification number: A61K31/575

Abstract: In this patent, we isolated a novel compound from fruiting body of Antrodia cinnamomea, namely, (22R)-5α-lanosta-8,24-dien-3β,15α,21-triol. This compound possesses preferential cytotoxicity against human leukemia, pancreatic cancer, esophageal cancer, hepatoma, and cervical cancer cells.

Abstract translation: 在这项专利中，我们从番茄子实体中分离出一种新的化合物，即（22R）-5α-羊毛甾-8,24-二烯-3β，15α，21-三醇。 该化合物对人白血病，胰腺癌，食管癌，肝癌和宫颈癌细胞具有优先的细胞毒性。

公开(公告)号：US20120309732A1

公开(公告)日：2012-12-06

申请号：US13483620

申请日：2012-05-30

Applicant: Yu-Jen Chen ,  Cheng-Jen Chou ,  Tun-Tschu Chang

Inventor： Yu-Jen Chen ,  Cheng-Jen Chou ,  Tun-Tschu Chang

IPC: A61K31/56 ,  A61P35/04 ,  A61P35/02 ,  C12N5/09

CPC classification number: A61K31/575

Abstract: In this patent, we isolated a novel compound from fruiting body of Antrodia cinnamomea, namely, (22R)-5α-lanosta-8,24-dien-3β,15α,21-triol. This compound possesses preferential cytotoxicity against human leukemia, pancreatic cancer, esophageal cancer, hepatoma, and cervical cancer cells.

Abstract translation: 在该专利中，我们分离出了一种新型的化合物，即，（22R）-5α-lanosta-8,24-二烯-3和bgr，15α，21-三醇的子实体。 该化合物对人白血病，胰腺癌，食管癌，肝癌和宫颈癌细胞具有优先的细胞毒性。

公开(公告)号：US20090318400A1

公开(公告)日：2009-12-24

申请号：US12265599

申请日：2008-11-05

Applicant: Yu-Jen Chen ,  Cheng-Jen Chou ,  Tun-Tschu Chang

Inventor： Yu-Jen Chen ,  Cheng-Jen Chou ,  Tun-Tschu Chang

IPC: A61K31/575 ,  A61P35/00

CPC classification number: A61K31/575

Abstract: The present invention relates to a method for inhibiting tumor growth, in particular to the method using dehydrosulphurenic acid to inhibit the growth of leukemia cell or pancreatic cancer cell by a compound extracted and purified from Antrodia cinnamomea. Dehydrosulphurenic acid of the invention can be used as a pharmaceutical composition to inhibit the tumor growth of leukemia or pancreatic cancer.

Abstract translation: 本发明涉及一种抑制肿瘤生长的方法，特别是涉及使用脱氢硫代酸通过从番茄红素提取和纯化的化合物抑制白血病细胞或胰腺癌细胞生长的方法。 本发明的脱氢硫酸可以用作抑制白血病或胰腺癌肿瘤生长的药物组合物。

公开(公告)号：US20100304495A1

公开(公告)日：2010-12-02

申请号：US12472383

申请日：2009-05-27

Applicant: Tun-Tschu CHANG ,  Wu-Rong WANG ,  Cheng-Jen Chou

Inventor： Tun-Tschu CHANG ,  Wu-Rong WANG ,  Cheng-Jen Chou

IPC: G01N33/50

CPC classification number: C12Q1/04 ,  G01N2333/375 ,  Y10T436/201666

Abstract: This invention relates to a method for determining fruiting body and mycelium of Antrodia cinnamomea and Antrodia salmonea. By using ten known components in Antrodia cinnamomea including five ergostanes (antcins C and K, zhankuic acids A, B and C), four lanostanes (sulphurenic acid, dehydrosulphurenic acid, eburicoic acid, dehydroeburicoic acid), and one monophenyl (4,7-dimethoxy-5-methyl-1,3-benzodioxole) as standards, differentiation of mycelia and basidiomes of Antrodia cinnamomea was carried out in the invention. The natural basidiomes collected from wood of Cinnamomum kanehirai at natural forests and the cultural basidiomes grown on potato dextrose agar medium contained all ten tested components. However, the natural mycelia collected from wood of C. kanehirai at a natural forest and the liquid/solid cultural mycelia grown on potato dextrose broth/potato dextrose agar media contained the four lanostanes and 4,7-dimethoxy-5-methyl-1,3-benzodioxole, but not the five ergostanes. These results indicate that the production of ergostanes is related to the basidiomatal formation of A. cinnamomea, but is not related to the grown substrates.

Abstract translation: 本发明涉及一种用于确定樟芝和茄子的结实体和菌丝体的方法。 通过使用包括五种麦角甾烷（antcdic C和K，zh ic酸A，B和C）的十种已知组分，四种山莨菪碱（硫脲酸，脱氢硫酸，eburicoic acid，脱氢伯布酸）和一个单苯基（4,7- 二甲氧基-5-甲基-1,3-苯并间二氧杂环戊烯）作为标准，在本发明中进行了肉桂酸菌的菌丝体和担子菌的分化。 在天然林中从樟木的木材中收集的天然担子菌和在马铃薯葡萄糖琼脂培养基上生长的文化遗传物质包含所有十个测试的组分。 然而，从天然森林的C. kanehirai的木材收集的天然菌丝体和在马铃薯葡萄糖肉汤/马铃薯葡萄糖琼脂培养基上生长的液体/固体培养菌丝体含有四种山梨糖醇和4,7-二甲氧基-5-甲基-1， 3-苯并间二氧杂环戊烯，但不是五种麦角甾烷。 这些结果表明，麦角甾烷的生产与肉桂肉桂的生物体形成有关，但与生长的底物无关。